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NeoBiotechnologies
CTLA4/CD152 (Negative Regulator of T-Cells) Monoclonal Antibody (L4P2F5.F10)
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Product Details
1493-MSM1-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Cat,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
L4P2F5.F10
Immunogen
A synthetic peptide from CTLA4 (exact sequence is proprietary)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Does not react with Human
Target Information
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD152; CD152 antigen; costimulatory molecule B7 receptor; CTLA-4; cytotoxic T lymphocyte-associated antigen 4; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; ICOS; soluble form; transmembrane form
Gene Aliases: BOS_1950; CD152; CTLA-4; Ctla4; Ly-56; sCTLA4
UniProt ID: (Mouse) P09793
Entrez Gene ID: (Bovine) 281732, (Cat) 493743, (Mouse) 12477, (Rat) 63835
immune system process
immune response
cellular response to DNA damage stimulus
negative regulation of B cell proliferation
negative regulation of T cell proliferation
positive regulation of apoptotic process
negative regulation of regulatory T cell differentiation
negative regulation of immune response
B cell receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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