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Proteintech
CUEDC2 Polyclonal Antibody
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Product Details
20123-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CUEDC2 Fusion Protein Ag13847 (1-226 aa encoded by BC000262)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MELERIVSA ALLAFVQTHL PEADLSGLDE VIFSYVLGVL EDLGPSGPSE ENFDMEAFTE MMEAYVPGFA HIPRGTIGDM MQKLSGQLSD ARNKENLQPQ SSGVQGQVPI SPEPLQRPEM LKEETRSSAA AAADTQDEAT GAEEELLPGV DVLLEVFPTC SVEQAQWVLA KARGDLEEAV QMLVEGKEEG PAAWEGPNQD LPRRLRGPQK DELKSFILQK YMMVDSA (1-226 aa encoded by BC000262)
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kappa-B by decreasing the activation of IKK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUE domain-containing protein 2
Gene Aliases: 3010002G01Rik; bA18I14.5; C10orf66; CUEDC2; HOYS6
UniProt ID: (Human) Q9H467, (Mouse) Q9CXX9
Entrez Gene ID: (Human) 79004, (Mouse) 67116
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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