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Invitrogen
CUEDC2 Polyclonal Antibody
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FIGURE: 1 / 1
CUEDC2 Antibody (PA5-23265) in WB
Western blot analysis of CUEDC2 in MCF7 cell lysate in the 1) absence and 2) presence of immunizing peptide, 3) NIH 3T3 cell lysate, and 4) human spleen cell lysate. Samples were incubated in CUEDC2 polyclonal antibody (Product # PA5-23265) using a dilution of 5 µg/mL.
Product Details
PA5-23265
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Human,
Mouse,
Non-human primate,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acid 250-287 of human CUEDC2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540789
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kappa-B by decreasing the activation of IKK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUE domain containing 2; CUE domain-containing protein 2
Gene Aliases: 3010002G01Rik; bA18I14.5; BOS_23387; C10orf66; CUEDC2; HOYS6
UniProt ID: (Bovine) Q3ZBN4, (Human) Q9H467, (Mouse) Q9CXX9
Entrez Gene ID: (Dog) 100855631, (Bovine) 516091, (Human) 79004, (Mouse) 67116
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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