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Product Details
PA5-115064
Product Specifications
Species Reactivity
Rat,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CELF2(Accession O95319), corresponding to amino acid residues S76-S126.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899700
Product Specific Information
Antibody detects endogenous levels of total CUGBP2.
Target Information
CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bruno-like protein 3; CELF 2; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 2; CUG-BP2; CUGBP Elav-like family member 2; Cugbp- and Etr3-like factor 2; ELAV-type RNA-binding protein 3; ETR-3; hNAPOR; mNapor; neur; Neuroblastoma apoptosis-related RNA-binding protein; RNA-binding protein BRUNOL-3; RNA-binding protein Brunol3; rNapor; RP23-124P7.1
Gene Aliases: B230218O03; B230345P09Rik; BRUNOL3; C88023; CELF-2; CELF2; CUG-BP2; CUGBP2; D230046B21Rik; ETR-3; ETR3; mETR-3; NAPOR; Napor-2
UniProt ID: (Human) O95319, (Rat) Q792H5, (Mouse) Q9Z0H4
Entrez Gene ID: (Human) 10659, (Rat) 29428, (Mouse) 14007
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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