Proteintech

CUL4B Polyclonal Antibody

CUL4B Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

CUL4B Antibody (12916-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CUL4B antibody (Product # 12916-1-AP) at dilution of 1:100 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red).

CUL4B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CUL4B Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12916-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 63 publications 63 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Dog, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CUL4B Fusion Protein Ag3563 (1-351 aa encoded by BC036216)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MMSQSSGSG DGNDDEATTS KDGGFSSPSP SAAAAAQEVR SATDGNTSTT PPTSAKKRKL NSSSSSSSNS SNEREDFDST SSSSSTPPLQ PRDSASPSTS SFCLGVSVAA SSHVPIQKKL RFEDTLEFVG FDAKMAEESS SSSSSSSPTA ATSQQQQLKN KSILISSVAS VHHANGLAKS STTVSSFANS KPGSAKKLVI KNFKDKPKLP ENYTDETWQK LKEAVEAIQN STSIKYNLEE LYQAVENLCS YKISANLYKQ LRQICEDHIK AQIHQFREDS LDSVLFLKKI DRCWQNHCRQ MIMIRSIFLF LDRTYVLQNS MLPSIWDMGL ELFRAHIISD QKVQNKTIDG IL (1-351 aa encoded by BC036216)

Target Information

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.

Cell metabolism

Yoshizawa T,Karim MF,Sato Y,Senokuchi T,Miyata K,Fukuda T,Go C,Tasaki M,Uchimura K,Kadomatsu T,Tian Z,Smolka C,Sawa T,Takeya M,Tomizawa K,Ando Y,Araki E,Akaike T,Braun T,Oike Y,Bober E,Yamagata K

Tue Apr 01 00:00:00 UTC 2014

AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.

Developmental cell

Antonioli M,Albiero F,Nazio F,Vescovo T,Perdomo AB,Corazzari M,Marsella C,Piselli P,Gretzmeier C,Dengjel J,Cecconi F,Piacentini M,Fimia GM

Mon Dec 22 00:00:00 UTC 2014

AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.

Developmental cell

Antonioli M,Albiero F,Nazio F,Vescovo T,Perdomo AB,Corazzari M,Marsella C,Piselli P,Gretzmeier C,Dengjel J,Cecconi F,Piacentini M,Fimia GM

Mon Dec 22 00:00:00 UTC 2014

CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.

Science (New York, N.Y.)

Yu C,Zhang YL,Pan WW,Li XM,Wang ZW,Ge ZJ,Zhou JJ,Cang Y,Tong C,Sun QY,Fan HY

Fri Dec 20 00:00:00 UTC 2013

CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.

Science (New York, N.Y.)

Yu C,Zhang YL,Pan WW,Li XM,Wang ZW,Ge ZJ,Zhou JJ,Cang Y,Tong C,Sun QY,Fan HY

Fri Dec 20 00:00:00 UTC 2013

CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.

Science (New York, N.Y.)

Yu C,Zhang YL,Pan WW,Li XM,Wang ZW,Ge ZJ,Zhou JJ,Cang Y,Tong C,Sun QY,Fan HY

Fri Dec 20 00:00:00 UTC 2013

A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.

The Journal of biological chemistry

Zhang S,Zhao H,Darzynkiewicz Z,Zhou P,Zhang Z,Lee EY,Lee MY

Fri Oct 11 00:00:00 UTC 2013

A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.

The Journal of biological chemistry

Zhang S,Zhao H,Darzynkiewicz Z,Zhou P,Zhang Z,Lee EY,Lee MY

Fri Oct 11 00:00:00 UTC 2013

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.

Cell research

Liu L,Yin Y,Li Y,Prevedel L,Lacy EH,Ma L,Zhou P

Wed Aug 01 00:00:00 UTC 2012

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.

Cell research

Liu L,Yin Y,Li Y,Prevedel L,Lacy EH,Ma L,Zhou P

Wed Aug 01 00:00:00 UTC 2012

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.

Cell research

Liu L,Yin Y,Li Y,Prevedel L,Lacy EH,Ma L,Zhou P

Wed Aug 01 00:00:00 UTC 2012

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.

Cell research

Liu L,Yin Y,Li Y,Prevedel L,Lacy EH,Ma L,Zhou P

Wed Aug 01 00:00:00 UTC 2012

Cul4B regulates neural progenitor cell growth.

BMC neuroscience

Liu HC,Enikolopov G,Chen Y

Wed Sep 19 00:00:00 UTC 2012

Cul4B regulates neural progenitor cell growth.

BMC neuroscience

Liu HC,Enikolopov G,Chen Y

Wed Sep 19 00:00:00 UTC 2012

Cul4B regulates neural progenitor cell growth.

BMC neuroscience

Liu HC,Enikolopov G,Chen Y

Wed Sep 19 00:00:00 UTC 2012

Cul4B regulates neural progenitor cell growth.

BMC neuroscience

Liu HC,Enikolopov G,Chen Y

Wed Sep 19 00:00:00 UTC 2012

The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis.

Developmental biology

Yin Y,Lin C,Kim ST,Roig I,Chen H,Liu L,Veith GM,Jin RU,Keeney S,Jasin M,Moley K,Zhou P,Ma L

Mon Aug 01 00:00:00 UTC 2011

The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis.

Developmental biology

Yin Y,Lin C,Kim ST,Roig I,Chen H,Liu L,Veith GM,Jin RU,Keeney S,Jasin M,Moley K,Zhou P,Ma L

Mon Aug 01 00:00:00 UTC 2011

Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.

Cancer cell

Aggarwal P,Vaites LP,Kim JK,Mellert H,Gurung B,Nakagawa H,Herlyn M,Hua X,Rustgi AK,McMahon SB,Diehl JA

Tue Oct 19 00:00:00 UTC 2010

Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.

Cancer cell

Aggarwal P,Vaites LP,Kim JK,Mellert H,Gurung B,Nakagawa H,Herlyn M,Hua X,Rustgi AK,McMahon SB,Diehl JA

Tue Oct 19 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: CUL-4B; cul4b; Cullin-4B

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Gene Aliases: 2700050M05Rik; AA409770; CUL-4B; CUL4B; KIAA0695; mKIAA0695; MRXHF2; MRXS15; MRXSC; SFM2

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UniProt ID: (Human) Q13620, (Mouse) A2A432

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Entrez Gene ID: (Human) 8450, (Mouse) 72584

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Function(s)

damaged DNA binding protein binding ubiquitin protein ligase binding ubiquitin protein ligase activity

Process(es)

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CUL4B Polyclonal Antibody

CUL4B Antibody (12916-1-AP) in ICC/IF

Product Details

12916-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

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