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Product Details
PA5-57796
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CWC22. Recombinant protein control fragment (Product #RP-96184).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2640260
Product Specific Information
Immunogen sequence: RNQQTNDRKQ KERRQEHGHQ ETRTERERRS EKHRDQNSRG SNWRDPITKY TSDKDVPSER NNYSRVANDR DQEMHIDLEN KHGDP
Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 48%.
Target Information
Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CWC22 spliceosome-associated protein homolog; fSAPb; functional spliceosome-associated protein b; Nucampholin homolog; Pre-mRNA-splicing factor CWC22 homolog
Gene Aliases: CWC22; EIF4GL; fSAPb; KIAA1604; NCM
UniProt ID: (Human) Q9HCG8
Entrez Gene ID: (Human) 57703
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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