Proteintech

CX3CL1 Polyclonal Antibody

CX3CL1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CX3CL1 Antibody (10108-2-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using (Product # 10108-2-AP) CX3CL1 antibody at dilution of 1:400 (under 10x lens).

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Product Details

10108-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CX3CL1 Fusion Protein Ag0161 (90-245 aa encoded by BC001163)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DRQAAALTR NGGTFEKQIG EVKPRTTPAA GGMDESVVLE PEATGESSSL EPTPSSQEAQ RALGTSPELP TGVTGSSGTR LPPTPKAQDG GPVGTELFRV PPVSTAATWQ SSAPHQPGPS LWAEAKTSEA PSTQDPSTQA STASSPAPEE NAPSEGQ (90-245 aa encoded by BC001163)

Target Information

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization.

Experimental and therapeutic medicine

Gao XW,Hu HL,Xie MH,Tang CX,Ou J,Lu ZH

Sat Jul 01 00:00:00 UTC 2023

Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis.

Journal of immunology research

Sun Y,Zhang XX,Huang S,Pan H,Gai YZ,Zhou YQ,Zhu L,Nie HZ,Li DX

Fri Apr 29 00:00:00 UTC 2022

The Clostridium Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.

Cells

Fu HY,Xu JM,Ai X,Dang FT,Tan X,Yu HY,Feng J,Yang WX,Ma HT,Tu RF,Gupta AK,Manandhar LK,Bao WM,Tang YM

Sat Nov 26 00:00:00 UTC 2022

Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.

International journal of biological sciences

Hou P,Lin T,Meng S,Shi M,Chen F,Jiang T,Li Z,Li M,Chu S,Zheng J,Bai J

Fri Mar 25 00:00:00 UTC 2022

Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1-CX3CR1 dependent manner and induce tumour cell apoptosis.

Molecular oncology

Miao S,Lu M,Liu Y,Shu D,Zhu Y,Song W,Ma Y,Ma R,Zhang B,Fang C,Ming ZY

Thu Oct 01 00:00:00 UTC 2020

Immunohistochemical and Molecular Investigations Show Alteration in the Inflammatory Profile of Multiple System Atrophy Brain.

Journal of neuropathology and experimental neurology

Kiely AP,Murray CE,Foti SC,Benson BC,Courtney R,Strand C,Lashley T,Holton JL

Sun Jul 01 00:00:00 UTC 2018

Immunohistochemical and Molecular Investigations Show Alteration in the Inflammatory Profile of Multiple System Atrophy Brain.

Journal of neuropathology and experimental neurology

Kiely AP,Murray CE,Foti SC,Benson BC,Courtney R,Strand C,Lashley T,Holton JL

Sun Jul 01 00:00:00 UTC 2018

Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.

Cell biochemistry and function

Wang H,Cai J,Du S,Guo Z,Xin B,Wang J,Wei W,Shen X

Tue Aug 01 00:00:00 UTC 2017

Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.

Cell biochemistry and function

Wang H,Cai J,Du S,Guo Z,Xin B,Wang J,Wei W,Shen X

Tue Aug 01 00:00:00 UTC 2017

Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.

Cell biochemistry and function

Wang H,Cai J,Du S,Guo Z,Xin B,Wang J,Wei W,Shen X

Tue Aug 01 00:00:00 UTC 2017

Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-κB cascade in pancreatic cancer cells.

Cell biochemistry and function

Wang H,Cai J,Du S,Guo Z,Xin B,Wang J,Wei W,Shen X

Tue Aug 01 00:00:00 UTC 2017

Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer.

The Journal of pathology

Boelens MC,van den Berg A,Fehrmann RS,Geerlings M,de Jong WK,te Meerman GJ,Sietsma H,Timens W,Postma DS,Groen HJ

Mon Jun 01 00:00:00 UTC 2009

Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer.

The Journal of pathology

Boelens MC,van den Berg A,Fehrmann RS,Geerlings M,de Jong WK,te Meerman GJ,Sietsma H,Timens W,Postma DS,Groen HJ

Mon Jun 01 00:00:00 UTC 2009

Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes.

Blood

Ma Y,Visser L,Roelofsen H,de Vries M,Diepstra A,van Imhoff G,van der Wal T,Luinge M,Alvarez-Llamas G,Vos H,Poppema S,Vonk R,van den Berg A

Fri Feb 15 00:00:00 UTC 2008

Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes.

Blood

Ma Y,Visser L,Roelofsen H,de Vries M,Diepstra A,van Imhoff G,van der Wal T,Luinge M,Alvarez-Llamas G,Vos H,Poppema S,Vonk R,van den Berg A

Fri Feb 15 00:00:00 UTC 2008

Bioinformatics

Protein Aliases: C-X3-C motif chemokine 1; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; Fractalkine; Neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; Small-inducible cytokine D1

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Gene Aliases: A-152E5.2; ABCD-3; C3Xkine; CX3CL1; CXC3; CXC3C; FKN; fractalkine; neurotactin; NTN; NTT; SCYD1

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UniProt ID: (Human) P78423

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Entrez Gene ID: (Human) 6376

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Function(s)

receptor binding integrin binding protein binding chemokine activity CX3C chemokine receptor binding CCR chemokine receptor binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CX3CL1 Polyclonal Antibody

CX3CL1 Antibody (10108-2-AP) in IHC (P)

Product Details

10108-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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