Fabgennix

CX3CL1 Polyclonal Antibody

View all (28) CX3CL1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CX3CL1-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid reigon 350-395 on mouse Fractalkine protein.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Target Information

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABCD-3; C-X3-C motif chemokine 1; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; FK; Fractalkine; Neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D, 1; Small-inducible cytokine D1

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Gene Aliases: A-152E5.2; AB030188; ABCD-3; Acc1; AI848747; C3Xkine; CX3C; CX3CL1; CXC3; CXC3C; D8Bwg0439e; FKN; fractalkine; neurotactin; NTN; NTT; SCYD1

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UniProt ID: (Human) P78423, (Rat) O55145, (Mouse) O35188

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Entrez Gene ID: (Human) 6376, (Rat) 89808, (Mouse) 20312

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Function(s)
receptor binding integrin binding protein binding chemokine activity CX3C chemokine receptor binding CCR chemokine receptor binding cytokine activity
Process(es)
response to hypoxia microglial cell activation positive regulation of neuroblast proliferation chemotaxis immune response cell adhesion aging positive regulation of macrophage chemotaxis cytokine-mediated signaling pathway platelet activation positive regulation of cell migration neutrophil chemotaxis positive regulation of transforming growth factor beta1 production wound healing positive regulation of angiogenesis positive regulation of cell adhesion negative regulation of vasoconstriction macrophage chemotaxis lymphocyte chemotaxis positive regulation of smooth muscle cell proliferation negative regulation of cytokine secretion positive regulation of inflammatory response positive regulation of calcium-independent cell-cell adhesion angiogenesis involved in wound healing inhibitory postsynaptic potential cell chemotaxis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand leukocyte adhesive activation leukocyte migration involved in inflammatory response monocyte chemotaxis defense response G-protein coupled receptor signaling pathway leukocyte chemotaxis integrin activation positive regulation of GTPase activity chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor
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