Proteintech

CXCL10/IP10 Polyclonal Antibody

CXCL10/IP10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CXCL10/IP10 Antibody (10937-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human nasopharyngeal carcinoma tissue slide using 10937-1-AP (CXCL10/IP10 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

10937-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CXCL10 Fusion Protein Ag1369

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1053 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

IP-10 (interferon-gamma induced protein 10 kD; in mouse, also called cytokine responsive gene 2, Crg-2, or mob-1) is a highly inducible, primary response gene that belongs to the CXC chemokine superfamily. It was first cloned in 1985. The biological functions of IP-10 are still unclear. Like Mig, IP-10 has no activity on neutrophils. Its functions include stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. Mig and IP-10 share the same receptor, CXCR3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

LRPPRC facilitates tumor progression and immune evasion through upregulation of m⁶A modification of PD-L1 mRNA in hepatocellular carcinoma.

Frontiers in immunology

Wang H,Tang A,Cui Y,Gong H,Li H

Tue Apr 18 00:00:00 UTC 2023

A new method for predicting the prognosis of colorectal cancer patients through a combination of multiple tumor-associated macrophage markers at the invasive front.

Heliyon

Wang X,Yuwen TJ,Zhong Y,Li ZG,Wang XY

Wed Feb 01 00:00:00 UTC 2023

A Novel Tri-Functional Liposome Re-Educates "Cold Tumor" and Abrogates Tumor Growth by Synergizing Autophagy Inhibition and PD-L1 Blockade.

Advanced healthcare materials

Zhou F,Li X,Xue X,Li S,Fan G,Cai Y,Chang Z,Qu J,Liu R

Sat Apr 01 00:00:00 UTC 2023

HDAC inhibitor HPTA initiates anti-tumor response by CXCL9/10-recruited CXCR3⁺CD4⁺T cells against PAHs carcinogenicity.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Chen C,Lim D,Cai Z,Zhang F,Liu G,Dong C,Feng Z

Thu Jun 01 00:00:00 UTC 2023

HMBOX1 attenuates LPS-induced periodontal ligament stem cell injury by inhibiting CXCL10 expression through the NF-κB signaling pathway.

Experimental and therapeutic medicine

Nie M,Li H,Liu P,Dang P

Tue Mar 01 00:00:00 UTC 2022

KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer.

Cancer communications (London, England)

Liu C,Zheng S,Wang Z,Wang S,Wang X,Yang L,Xu H,Cao Z,Feng X,Xue Q,Wang Y,Sun N,He J

Thu Sep 01 00:00:00 UTC 2022

Transcriptome-Based Dissection of Intracranial Aneurysms Unveils an "Immuno-Thermal" Microenvironment and Defines a Pathological Feature-Derived Gene Signature for Risk Estimation.

Frontiers in immunology

Lu T,Liu Z,Guo D,Ma C,Duan L,He Y,Jia R,Guo C,Xing Z,Liu Y,Li T,He Y

Mon Jun 20 00:00:00 UTC 2022

Magnetic hyperthermia induces effective and genuine immunogenic tumor cell death with respect to exogenous heating.

Journal of materials chemistry. B

Yan B,Liu C,Wang S,Li H,Jiao J,Lee WSV,Zhang S,Hou Y,Hou Y,Ma X,Fan H,Lv Y,Liu X

Wed Jul 20 00:00:00 UTC 2022

Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Gao L,Yang WY,Qi H,Sun CJ,Qin XM,Du GH

Sun May 01 00:00:00 UTC 2022

CD11c⁺ B Cells Participate in the Pathogenesis of Graves' Disease by Secreting Thyroid Autoantibodies and Cytokines.

Frontiers in immunology

Cao Y,Zhao X,You R,Zhang Y,Qu C,Huang Y,Yu Y,Gong Y,Cong T,Zhao E,Zhang L,Gao Y,Zhang J

Fri Apr 08 00:00:00 UTC 2022

A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma.

Nature communications

Lu Y,Yang A,Quan C,Pan Y,Zhang H,Li Y,Gao C,Lu H,Wang X,Cao P,Chen H,Lu S,Zhou G

Sat Aug 06 00:00:00 UTC 2022

Activation of the chemokine receptor 3 pathway leads to a better response to immune checkpoint inhibitors in patients with metastatic urothelial carcinoma.

Cancer cell international

Feng W,Lin A,Sun L,Wei T,Ying H,Zhang J,Luo P,Zhu W

Fri May 13 00:00:00 UTC 2022

TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.

Journal of gastroenterology and hepatology

Ma HL,Chen SD,Zheng KI,Yu Y,Wang XX,Tang LJ,Li G,Rios RS,Huang OY,Zheng XY,Xu RA,Targher G,Byrne CD,Wang XD,Chen YP,Zheng MH

Fri Oct 01 00:00:00 UTC 2021

Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma.

American journal of cancer research

Wei Y,Yang X,Gao L,Yang J,Zheng L,Gao L,Zhou X,Xiang X,Zhang J,Yi C

Sat Nov 13 00:00:00 UTC 2021

Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.

Journal of agricultural and food chemistry

Luo N,Yang C,Zhu Y,Chen Q,Zhang B

Wed Jan 20 00:00:00 UTC 2021

The role of IP-10 and its receptor CXCR3 in early pregnancy.

Molecular immunology

Jiang Y,Huang F,Chai X,Yuan W,Ding H,Wu X

Wed Dec 01 00:00:00 UTC 2021

The role of IP-10 and its receptor CXCR3 in early pregnancy.

Molecular immunology

Jiang Y,Huang F,Chai X,Yuan W,Ding H,Wu X

Wed Dec 01 00:00:00 UTC 2021

C-X-C Motif Chemokine 10 Contributes to the Development of Neuropathic Pain by Increasing the Permeability of the Blood-Spinal Cord Barrier.

Frontiers in immunology

Li HL,Huang Y,Zhou YL,Teng RH,Zhou SZ,Lin JP,Yang Y,Zhu SM,Xu H,Yao YX

Mon Mar 29 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: 10 kDa interferon gamma-induced protein; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 10; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 10; CXC; CXC motif chemokine; CXCL; gamma IP10; Gamma-IP10; H-IP-10; interferon-inducible cytokine IP-10; M-IP-10; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10; Small-inducible cytokine B10

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Gene Aliases: C7; crg-2; CXCL10; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10

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UniProt ID: (Human) P02778

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Entrez Gene ID: (Human) 3627

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Function(s)

receptor binding protein binding chemokine activity heparin binding cAMP-dependent protein kinase regulator activity CXCR3 chemokine receptor binding

Process(es)

chemotaxis inflammatory response immune response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway cell-cell signaling muscle organ development blood circulation positive regulation of cell proliferation response to cold response to gamma radiation T cell chemotaxis regulation of T cell chemotaxis response to auditory stimulus negative regulation of angiogenesis positive regulation of cAMP metabolic process response to vitamin D cellular response to heat endothelial cell activation regulation of cell proliferation positive regulation of cAMP-mediated signaling negative regulation of myoblast differentiation regulation of protein kinase activity positive regulation of transcription from RNA polymerase II promoter positive regulation of release of sequestered calcium ion into cytosol defense response to virus chemokine-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of monocyte chemotaxis regulation of endothelial tube morphogenesis negative regulation of myoblast fusion positive regulation of T cell migration

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CXCL10/IP10 Polyclonal Antibody

CXCL10/IP10 Antibody (10937-1-AP) in IHC (P)

Product Details

10937-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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