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Invitrogen
CXCL12 Polyclonal Antibody
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Product Details
PA1-29029
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein was generated using E. coli-expressed mouse SDF-1 alpha.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2276940
Product Specific Information
PA1-29029 detects CXCL12 from rat and mouse samples.
Target Information
CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; AI174028; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 12; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXC; CXC motif chemokine; CXCL; hIRH; hSDF-1; PBSF; Pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SDF-1; SDF-1 gamma; SDF-1a; SDF-1b; Stromal cell-derived factor 1; stromal cell-derived factor-1 alpha; stromal cell-derived factor-1 gamma; Thymic lymphoma cell-stimulating factor; TLSF; TLSF-a; TLSF-b; Tlsfa; Tlsfb; TPAR1
Gene Aliases: Cxcl12; Pbsf; Scyb12; Sdf1; Tlsf; Tpar1
UniProt ID: (Mouse) P40224
Entrez Gene ID: (Rat) 24772, (Mouse) 20315
patterning of blood vessels
response to hypoxia
ameboidal-type cell migration
neuron migration
positive regulation of endothelial cell proliferation
immune response
germ cell development
brain development
motor neuron axon guidance
positive regulation of cell proliferation
adult locomotory behavior
germ cell migration
response to radiation
response to heat
response to mechanical stimulus
cell migration
telencephalon cell migration
regulation of cell migration
positive regulation of cell migration
organ regeneration
positive regulation of dopamine secretion
T cell proliferation
response to peptide hormone
positive regulation of neuron differentiation
positive regulation of cell adhesion
positive regulation of axon extension involved in axon guidance
induction of positive chemotaxis
regulation of calcium ion transport
cell chemotaxis
chemokine-mediated signaling pathway
positive regulation of monocyte chemotaxis
positive regulation of myoblast fusion
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of leukocyte tethering or rolling
negative regulation of leukocyte apoptotic process
positive regulation of T cell migration
chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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