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Invitrogen
CXCL17 Monoclonal Antibody (510614)
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FIGURE: 1 / 1
CXCL17 Antibody (MA5-24222) in WB
Western blot analysis from lysates of mouse lung tissue. PVDF membrane was probed with 2 µg/mL of Rat Anti-mouse CXCL17 Monoclonal Antibody (Product # MA5-24222) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody. A specific band was detected for CXCL17 at approximately 11 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
MA5-24222
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
510614
Immunogen
E. coli-derived recombinant mouse CXCL17/VCC-1 Ser31-Leu119
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607447
Product Specific Information
This antibody detects recombinant mouse (rm) CXCL17/VCC-1 in direct ELISAs and Western blots. In direct ELISAs, 50% cross-reactivity with recombinant human CXCL17 is observed/VCC-1.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
CXCL17 is a chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. In particular, CXCL17 is a mucosal chemokine that attracts dendritic cells and blood monocytes to the lungs. CXCL17 plays a role in angiogenesis and possibly in the development of tumors. Further, CXCL17 acts as an anti-inflammatory in the stomach and may play a role in the innate defense against infections. CXCL17 also activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions. 4-Cys CXCL17 seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. Diseases associated with CXCL17 dysfunction include cholera.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 13.6 kDa protein; 13.6-kDa protein; 6-Cys CXCL17; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 17; CC motif chemokine; CCmotif chemokine; CXC; CXC motif chemokine; CXCL; VEGF co-regulated chemokine 1; VEGF coregulated chemokine 1
Gene Aliases: Cxcl17; VCC-1; Vcc1
UniProt ID: (Mouse) Q5UW37
Entrez Gene ID: (Mouse) 232983
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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