Proteintech

CXCR3B Monoclonal Antibody (1B2D6)

18 References

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (11)

CXCR3B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 11

CXCR3B Antibody (60065-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 60065-1-Ig (CXCR3B-specific antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CXCR3B Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

60065-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Flow Cytometry (Flow)

Assay-dependent

View 3 publications 3 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

1B2D6

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This monoclonal antibody is specific to CXCR3B.

Target Information

Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Historically, CD183 was the third CXC chemokine receptor discovered and therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. The CXC chemokine receptor (CXCR) 3, a G-protein-coupled 7-transmembrane receptor, is expressed at high levels on activated and memory T cells, B cells, natural killer cells, and plasmacytoid monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CXCR3 isoform A promotes head and neck cancer progression by enhancing stem-like property and chemoresistance.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Sun WH,Peng TJ,Tang SJ,Lin JY,Wang CY,Fang HJ,Sun KH

Sat Oct 01 00:00:00 UTC 2022

A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma.

Nature communications

Lu Y,Yang A,Quan C,Pan Y,Zhang H,Li Y,Gao C,Lu H,Wang X,Cao P,Chen H,Lu S,Zhou G

Sat Aug 06 00:00:00 UTC 2022

Activation of the chemokine receptor 3 pathway leads to a better response to immune checkpoint inhibitors in patients with metastatic urothelial carcinoma.

Cancer cell international

Feng W,Lin A,Sun L,Wei T,Ying H,Zhang J,Luo P,Zhu W

Fri May 13 00:00:00 UTC 2022

Genistein suppresses allergic contact dermatitis through regulating the MAP2K2/ERK pathway.

Food & function

Xu J,Xiong H,Zhao Z,Luo M,Ju Y,Yang G,Mei Z

Fri May 21 00:00:00 UTC 2021

CXCL11 promotes tumor progression by the biased use of the chemokine receptors CXCR3 and CXCR7.

Cytokine

Puchert M,Obst J,Koch C,Zieger K,Engele J

Wed Jan 01 00:00:00 UTC 2020

CXCL12-CXCL4 heterodimerization prevents CXCL12-driven breast cancer cell migration.

Cellular signalling

Nguyen KTP,Druhan LJ,Avalos BR,Zhai L,Rauova L,Nesmelova IV,Dréau D

Sat Feb 01 00:00:00 UTC 2020

Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer.

Cell communication and signaling : CCS

Ma B,Khazali A,Shao H,Jiang Y,Wells A

Thu Dec 12 00:00:00 UTC 2019

The Chemokine Receptor CXCR3 Isoform B Drives Breast Cancer Stem Cells.

Breast cancer : basic and clinical research

Kundu N,Ma X,Brox R,Fan X,Kochel T,Reader J,Tschammer N,Fulton A

Wed Sep 30 00:00:00 UTC 2020

Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo.

Nature communications

Tulic MK,Cavazza E,Cheli Y,Jacquel A,Luci C,Cardot-Leccia N,Hadhiri-Bzioueche H,Abbe P,Gesson M,Sormani L,Regazzetti C,Beranger GE,Lereverend C,Pons C,Khemis A,Ballotti R,Bertolotto C,Rocchi S,Passeron T

Thu May 16 00:00:00 UTC 2019

Upregulation of angiostatic chemokines IP-10/CXCL10 and I-TAC/CXCL11 in human obesity and their implication for adipose tissue angiogenesis.

International journal of obesity (2005)

Hueso L,Ortega R,Selles F,Wu-Xiong NY,Ortega J,Civera M,Ascaso JF,Sanz MJ,Real JT,Piqueras L

Wed Aug 01 00:00:00 UTC 2018

Upregulation of angiostatic chemokines IP-10/CXCL10 and I-TAC/CXCL11 in human obesity and their implication for adipose tissue angiogenesis.

International journal of obesity (2005)

Hueso L,Ortega R,Selles F,Wu-Xiong NY,Ortega J,Civera M,Ascaso JF,Sanz MJ,Real JT,Piqueras L

Wed Aug 01 00:00:00 UTC 2018

Upregulation of angiostatic chemokines IP-10/CXCL10 and I-TAC/CXCL11 in human obesity and their implication for adipose tissue angiogenesis.

International journal of obesity (2005)

Hueso L,Ortega R,Selles F,Wu-Xiong NY,Ortega J,Civera M,Ascaso JF,Sanz MJ,Real JT,Piqueras L

Wed Aug 01 00:00:00 UTC 2018

Upregulation of angiostatic chemokines IP-10/CXCL10 and I-TAC/CXCL11 in human obesity and their implication for adipose tissue angiogenesis.

International journal of obesity (2005)

Hueso L,Ortega R,Selles F,Wu-Xiong NY,Ortega J,Civera M,Ascaso JF,Sanz MJ,Real JT,Piqueras L

Wed Aug 01 00:00:00 UTC 2018

Overexpression of the chemokine receptor CXCR3 and its correlation with favorable prognosis in gastric cancer.

Human pathology

Hu M,Li K,Maskey N,Xu Z,Yu F,Peng C,Li Y,Yang G

Tue Dec 01 00:00:00 UTC 2015

Overexpression of the chemokine receptor CXCR3 and its correlation with favorable prognosis in gastric cancer.

Human pathology

Hu M,Li K,Maskey N,Xu Z,Yu F,Peng C,Li Y,Yang G

Tue Dec 01 00:00:00 UTC 2015

Differential regulation of pericyte function by the CXC receptor 3.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Bodnar RJ,Wells A

Mon Oct 17 00:00:00 UTC 2016

Differential regulation of pericyte function by the CXC receptor 3.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Bodnar RJ,Wells A

Mon Oct 17 00:00:00 UTC 2016

A novel CXCR3-B chemokine receptor-induced growth-inhibitory signal in cancer cells is mediated through the regulation of Bach-1 protein and Nrf2 protein nuclear translocation.

The Journal of biological chemistry

Balan M,Pal S

Fri Feb 07 00:00:00 UTC 2014

A novel CXCR3-B chemokine receptor-induced growth-inhibitory signal in cancer cells is mediated through the regulation of Bach-1 protein and Nrf2 protein nuclear translocation.

The Journal of biological chemistry

Balan M,Pal S

Fri Feb 07 00:00:00 UTC 2014

A novel CXCR3-B chemokine receptor-induced growth-inhibitory signal in cancer cells is mediated through the regulation of Bach-1 protein and Nrf2 protein nuclear translocation.

The Journal of biological chemistry

Balan M,Pal S

Fri Feb 07 00:00:00 UTC 2014

A novel CXCR3-B chemokine receptor-induced growth-inhibitory signal in cancer cells is mediated through the regulation of Bach-1 protein and Nrf2 protein nuclear translocation.

The Journal of biological chemistry

Balan M,Pal S

Fri Feb 07 00:00:00 UTC 2014

Pericyte regulation of vascular remodeling through the CXC receptor 3.

Arteriosclerosis, thrombosis, and vascular biology

Bodnar RJ,Rodgers ME,Chen WC,Wells A

Sun Dec 01 00:00:00 UTC 2013

Pericyte regulation of vascular remodeling through the CXC receptor 3.

Arteriosclerosis, thrombosis, and vascular biology

Bodnar RJ,Rodgers ME,Chen WC,Wells A

Sun Dec 01 00:00:00 UTC 2013

Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion.

Molecular cancer

Wu Q,Dhir R,Wells A

Wed Jan 11 00:00:00 UTC 2012

Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion.

Molecular cancer

Wu Q,Dhir R,Wells A

Wed Jan 11 00:00:00 UTC 2012

Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion.

Molecular cancer

Wu Q,Dhir R,Wells A

Wed Jan 11 00:00:00 UTC 2012

Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion.

Molecular cancer

Wu Q,Dhir R,Wells A

Wed Jan 11 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: C-X-C chemokine receptor type 3; CD183; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; CKR-L2; CXC-R3; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; Mig receptor

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Gene Aliases: CD182; CD183; CKR-L2; CMKAR3; CXCR3; GPR9; IP10-R; Mig-R; MigR

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UniProt ID: (Human) P49682

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Entrez Gene ID: (Human) 2833

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Function(s)

chemokine receptor activity C-X-C chemokine receptor activity chemokine binding

Process(es)

angiogenesis regulation of leukocyte migration apoptotic process movement of cell or subcellular component chemotaxis inflammatory response cell adhesion cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration T cell chemotaxis calcium-mediated signaling chemokine-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CXCR3B Monoclonal Antibody (1B2D6)

CXCR3B Antibody (60065-1-IG) in IHC (P)

Product Details

60065-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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