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CXCR7 (ACKR3) (extracellular) Antibody (ACR-037-200UL) in WB
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4)brainlysates: - 1,2. Anti-CXCR7 (ACKR3) (extracellular) Antibody (#ACR-037), (1:400).3,4. Anti-CXCR7 (ACKR3) (extracellular) Antibody , preincubated with CXCR7/ACKR3 (extracellular) Blocking Peptide (#BLP-CR037).
Product Details
ACR-037-200UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)DVHLFDYVEPGNYSD, corresponding to amino acid residues 2-16 of rat CXCR7 (ACKR3), Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Atypical chemokine receptor 3; C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 7; CC motif chemokine; CCmotif chemokine; chemokine; chemokine (C-X-C motif) receptor 7; Chemokine orphan receptor 1; CXC; CXC motif chemokine; CXC-R7; CXCR-7; G protein-coupled receptor; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
Gene Aliases: ACKR3; AW541270; CMKOR1; CXC-R7; CXCR-7; CXCR7; GPR159; RDC-1; RDC1
UniProt ID: (Human) P25106, (Rat) O89039, (Mouse) P56485
Entrez Gene ID: (Human) 57007, (Rat) 84348, (Mouse) 12778
angiogenesis
vasculogenesis
chemotaxis
cell adhesion
G-protein coupled receptor signaling pathway
receptor internalization
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of defense response to virus by host
viral process
xenophagy
signal transduction
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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