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CXXC5 Polyclonal Antibody

CXXC5 Antibody in Immunocytochemistry (ICC/IF)

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CXXC5 Antibody (16513-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 16513-1-AP (CXXC5 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CXXC5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CXXC5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16513-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

ChIP assay (ChIP)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CXXC5 Fusion Protein Ag9733 (96-322 aa encoded by BC017439)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MMGGESADK ATAAAAAASL LANGHDLAAA MAVDKSNPTS KHKSGAVASL LSKAERATEL AAEGQLTLQQ FAQSTEMLKR VVQEHLPLMS EAGAGLPDME AVAGAEALNG QSDFPYLGAF PINPGLFIMT PAGVFLAESA LHMAGLAEYP MQGELASAIS SGKKKRKRCG MCAPCRRRIN CEQCSSCRNR KTGHQICKFR KCEELKKKPS AALEKVMLPT GAAFRWFQ (96-322 aa encoded by BC017439 )

Target Information

CXXC5 is zinc finger protein closely related to the DVL1-binding protein CXXC4 (also known as Idax), and like CXXC4 is thought to modulate the Wnt signaling pathway during development. CXXC5 is upregulated in neural stem cells upon BMP4 stimulation, leading to decreased levels of the Wnt-signaling target AXIN2 and facilitated the response of the stem cells to Wnt3a. Recent reports suggest CXXC5 transcription is activated by the Wilms tumor 1 (WT1) transcription factor, and together are involved in the WNT/beta-catenin pathway and play a role in embryonic kidney development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway.

The Journal of biological chemistry

Wang W,Zhang Z,Zhao M,Wang Y,Ge Y,Shan L

Sun Jan 01 00:00:00 UTC 2023

The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.

Haematologica

Astori A,Matherat G,Munoz I,Gautier EF,Surdez D,Zermati Y,Verdier F,Zaidi S,Feuillet V,Kadi A,Lauret E,Delattre O,Lefèvre C,Fontenay M,Ségal-Bendirdjian E,Dusanter-Fourt I,Bouscary D,Hermine O,Mayeux P,Pendino F

Sat Jan 01 00:00:00 UTC 2022

The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.

Haematologica

Sat Jan 01 00:00:00 UTC 2022

Role of Wnt/β-catenin signaling pathway in ameloblast differentiation in relevance to dental fluorosis.

Chemico-biological interactions

Zou T,Ma L,Gu L,Xi S,Zhang K,Guo X

Tue Nov 01 00:00:00 UTC 2022

Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation.

Frontiers in cell and developmental biology

Wu X,Dong W,Kong M,Ren H,Wang J,Shang L,Zhu Z,Zhu W,Shi X

Sat Oct 09 00:00:00 UTC 2021

Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation.

Frontiers in cell and developmental biology

Wu X,Dong W,Kong M,Ren H,Wang J,Shang L,Zhu Z,Zhu W,Shi X

Sat Oct 09 00:00:00 UTC 2021

Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation.

Frontiers in cell and developmental biology

Wu X,Dong W,Kong M,Ren H,Wang J,Shang L,Zhu Z,Zhu W,Shi X

Sat Oct 09 00:00:00 UTC 2021

Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation.

Frontiers in cell and developmental biology

Wu X,Dong W,Kong M,Ren H,Wang J,Shang L,Zhu Z,Zhu W,Shi X

Sat Oct 09 00:00:00 UTC 2021

A noncanonical AR addiction drives enzalutamide resistance in prostate cancer.

Nature communications

He Y,Wei T,Ye Z,Orme JJ,Lin D,Sheng H,Fazli L,Jeffrey Karnes R,Jimenez R,Wang L,Wang L,Gleave ME,Wang Y,Shi L,Huang H

Tue Mar 09 00:00:00 UTC 2021

A noncanonical AR addiction drives enzalutamide resistance in prostate cancer.

Nature communications

He Y,Wei T,Ye Z,Orme JJ,Lin D,Sheng H,Fazli L,Jeffrey Karnes R,Jimenez R,Wang L,Wang L,Gleave ME,Wang Y,Shi L,Huang H

Tue Mar 09 00:00:00 UTC 2021

A noncanonical AR addiction drives enzalutamide resistance in prostate cancer.

Nature communications

He Y,Wei T,Ye Z,Orme JJ,Lin D,Sheng H,Fazli L,Jeffrey Karnes R,Jimenez R,Wang L,Wang L,Gleave ME,Wang Y,Shi L,Huang H

Tue Mar 09 00:00:00 UTC 2021

NUDT21 negatively regulates PSMB2 and CXXC5 by alternative polyadenylation and contributes to hepatocellular carcinoma suppression.

Oncogene

Tan S,Li H,Zhang W,Shao Y,Liu Y,Guan H,Wu J,Kang Y,Zhao J,Yu Q,Gu Y,Ding K,Zhang M,Qian W,Zhu Y,Cai H,Chen C,Lobie PE,Zhao X,Sun J,Zhu T

Wed Aug 01 00:00:00 UTC 2018

NUDT21 negatively regulates PSMB2 and CXXC5 by alternative polyadenylation and contributes to hepatocellular carcinoma suppression.

Oncogene

Tan S,Li H,Zhang W,Shao Y,Liu Y,Guan H,Wu J,Kang Y,Zhao J,Yu Q,Gu Y,Ding K,Zhang M,Qian W,Zhu Y,Cai H,Chen C,Lobie PE,Zhao X,Sun J,Zhu T

Wed Aug 01 00:00:00 UTC 2018

Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs.

The Journal of experimental medicine

Ma S,Wan X,Deng Z,Shi L,Hao C,Zhou Z,Zhou C,Fang Y,Liu J,Yang J,Chen X,Li T,Zang A,Yin S,Li B,Plumas J,Chaperot L,Zhang X,Xu G,Jiang L,Shen N,Xiong S,Gao X,Zhang Y,Xiao H

Mon May 01 00:00:00 UTC 2017

Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs.

The Journal of experimental medicine

Ma S,Wan X,Deng Z,Shi L,Hao C,Zhou Z,Zhou C,Fang Y,Liu J,Yang J,Chen X,Li T,Zang A,Yin S,Li B,Plumas J,Chaperot L,Zhang X,Xu G,Jiang L,Shen N,Xiong S,Gao X,Zhang Y,Xiao H

Mon May 01 00:00:00 UTC 2017

KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors.

Scientific reports

Cui Z,Shen Y,Chen KH,Mittal SK,Yang JY,Zhang G

Mon Jan 09 00:00:00 UTC 2017

KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors.

Scientific reports

Cui Z,Shen Y,Chen KH,Mittal SK,Yang JY,Zhang G

Mon Jan 09 00:00:00 UTC 2017

CXXC5 is required for cardiac looping relating to TGFβ signaling pathway in zebrafish.

International journal of cardiology

Peng X,Li G,Wang Y,Zhuang J,Luo R,Chen J,Chen F,Shi Y,Li J,Zhou Z,Mo X,Liu X,Yuan W,Zeng Q,Li Y,Jiang Z,Wan Y,Ye X,Xu W,Wang X,Fan X,Zhu P,Wu X,Deng Y

Fri Jul 01 00:00:00 UTC 2016

CXXC5 is required for cardiac looping relating to TGFβ signaling pathway in zebrafish.

International journal of cardiology

Peng X,Li G,Wang Y,Zhuang J,Luo R,Chen J,Chen F,Shi Y,Li J,Zhou Z,Mo X,Liu X,Yuan W,Zeng Q,Li Y,Jiang Z,Wan Y,Ye X,Xu W,Wang X,Fan X,Zhu P,Wu X,Deng Y

Fri Jul 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: CF5; CXXC finger 5 protein; CXXC-type zinc finger protein 5; Putative MAPK-activating protein PM08; Putative NF-kappa-B-activating protein 102; Retinoid-inducible nuclear factor; RINF; WT1-induced Inhibitor of Dishevelled

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Gene Aliases: 4930415K17Rik; CF5; CXXC5; HSPC195; RINF; TCCCIA00297; WID

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UniProt ID: (Human) Q7LFL8, (Mouse) Q91WA4

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Entrez Gene ID: (Human) 51523, (Mouse) 67393

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Function(s)

signal transducer activity protein binding transcription factor binding zinc ion binding sequence-specific DNA binding DNA binding metal ion binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated signal transduction positive regulation of I-kappaB kinase/NF-kappaB signaling

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CXXC5 Polyclonal Antibody

CXXC5 Antibody (16513-1-AP) in ICC/IF

Product Details

16513-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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