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Product Details
PA5-75653
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human CYBA.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719381
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytochrome b light chain; Cytochrome b(558) alpha chain; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; Cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; cytochrome b558 alpha-subunit; Cytochrome b558 subunit alpha; cytochrome beta-558; flavocytochrome b-558 alpha polypeptide; Neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22 phox; p22-phox; p22phox; Superoxide-generating NADPH oxidase light chain subunit
Gene Aliases: b558; CYBA; nmf333; p22-PHOX; p22phox
UniProt ID: (Human) P13498, (Mouse) Q61462, (Rat) Q62737
Entrez Gene ID: (Human) 1535, (Mouse) 13057, (Rat) 79129
positive regulation of endothelial cell proliferation
negative regulation of glomerular filtration by angiotensin
superoxide metabolic process
transport
inflammatory response
regulation of blood pressure
smooth muscle hypertrophy
cytochrome complex assembly
positive regulation of cell growth
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of superoxide anion generation
positive regulation of toll-like receptor 2 signaling pathway
superoxide anion generation
innate immune response
respiratory burst
positive regulation of smooth muscle cell proliferation
hydrogen peroxide biosynthetic process
positive regulation of phagocytosis
regulation of release of sequestered calcium ion into cytosol
oxidation-reduction process
positive regulation of mucus secretion
cellular response to organic substance
reactive oxygen species metabolic process
positive regulation of defense response to bacterium
positive regulation of reactive oxygen species biosynthetic process
response to reactive oxygen species
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
response to nutrient levels
response to drug
cell redox homeostasis
vascular endothelial growth factor receptor signaling pathway
response to interleukin-1
cellular response to amino acid stimulus
cellular response to mechanical stimulus
cellular response to glucose stimulus
cellular response to tumor necrosis factor
cellular response to organic cyclic compound
cellular response to gamma radiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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