Invitrogen

CYBA Polyclonal Antibody

View all (8) CYBA antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-99812

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CYBA(Accession P13498), corresponding to amino acid residues M1-R32.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818745

Product Specific Information

Antibody detects endogenous levels of total CYBA.

Target Information

Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cytochrome b light chain; Cytochrome b(558) alpha chain; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; Cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; cytochrome b558 alpha-subunit; Cytochrome b558 subunit alpha; cytochrome beta-558; flavocytochrome b-558 alpha polypeptide; Neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22 phox; p22-phox; p22phox; Superoxide-generating NADPH oxidase light chain subunit

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Gene Aliases: b558; CYBA; nmf333; p22-PHOX; p22phox

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UniProt ID: (Human) P13498, (Mouse) Q61462, (Rat) Q62737

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Entrez Gene ID: (Human) 1535, (Mouse) 13057, (Rat) 79129

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Function(s)
protein binding electron carrier activity superoxide-generating NADPH oxidase activity SH3 domain binding heme binding metal ion binding protein heterodimerization activity oxidoreductase activity
Process(es)
positive regulation of endothelial cell proliferation negative regulation of glomerular filtration by angiotensin superoxide metabolic process transport inflammatory response regulation of blood pressure smooth muscle hypertrophy cytochrome complex assembly positive regulation of cell growth positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of superoxide anion generation positive regulation of toll-like receptor 2 signaling pathway superoxide anion generation innate immune response respiratory burst positive regulation of smooth muscle cell proliferation hydrogen peroxide biosynthetic process positive regulation of phagocytosis regulation of release of sequestered calcium ion into cytosol oxidation-reduction process positive regulation of mucus secretion cellular response to organic substance reactive oxygen species metabolic process positive regulation of defense response to bacterium positive regulation of reactive oxygen species biosynthetic process response to reactive oxygen species antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent response to nutrient levels response to drug cell redox homeostasis vascular endothelial growth factor receptor signaling pathway response to interleukin-1 cellular response to amino acid stimulus cellular response to mechanical stimulus cellular response to glucose stimulus cellular response to tumor necrosis factor cellular response to organic cyclic compound cellular response to gamma radiation
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