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Bioss
CYP11B1 Polyclonal Antibody
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CYP11B1 Antibody (BS-3898R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Rat thyroid gland; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with CYP11B1 Polyclonal Antibody, Unconjugated (bs-3898R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (bs-... View More
Product Details
BS-3898R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CYP11B1, amino acids 301-400.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aldosterone synthase; CYP11B1; CYPXIB1; Cytochrome P-450c11; Cytochrome P450 11B1, mitochondrial; cytochrome p450 XIB1; cytochrome P450(11 beta)-DS; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); Cytochrome P450C11; DKFZp686B05283; FLJ36771; P450(11 beta)-DS; P450C 11; P450C11; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B1; steroid 11-beta-monooxygenase; steroid-11-beta-hydroxylase
Gene Aliases: AA389061; Cp11ba; CPN1; CYP11B; Cyp11b-1; CYP11B1; FHI; P450C11; RATCP11BA; S11BH
UniProt ID: (Human) P15538
Entrez Gene ID: (Human) 1584, (Mouse) 110115, (Rat) 500892
regulation of blood volume by renal aldosterone
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
aldosterone biosynthetic process
potassium ion homeostasis
sodium ion homeostasis
oxidation-reduction process
immune response
cholesterol metabolic process
regulation of blood pressure
sterol metabolic process
cellular response to hormone stimulus
cortisol biosynthetic process
cellular response to potassium ion
glucose homeostasis
secondary metabolite biosynthetic process
cellular response to peptide hormone stimulus
steroid biosynthetic process
steroid metabolic process
glucocorticoid metabolic process
dibenzo-p-dioxin metabolic process
response to drug
adenosine metabolic process
cellular response to interferon-gamma
response to dexamethasone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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