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Abnova
CYP11B1 Polyclonal Antibody, MaxPab™
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Product Details
H00001584-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CYP11B1 (AAH96285.1, 1 a.a. approximately 574 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MALRAKAEVC MAVPWLSLQR AQALGTRAAR VPRTVLPFEA MPRRPGNRWL RLLQIWREQG YEDLHLEVHQ TFQELGPIFR SRHSASFGRW GRSAARAGLW RCQGRGWCRA NPSSLQRGQD SEALKYDLGG AGMVCVMLPE DVEKLQQVDS LHPHRMSLEP WVAYRQHRGH KCGVFLLNVA DRGNSSPPFP GGIHGAPTHS GCRNGPEWRF NRLRLNPEVL SPNAVQRFLP MVDAVARDFS QALKKKVLQN ARGSLTLDVQ PSIFHYTIEA SNLALFGERL GLVGHSPSSA SLNFLHALEV MFKSTVQLMF MPRSLSRWTS PKVWKEHFEA WDCIFQYGDN CIQKIYQELA FSRPQQYTSI VAELLLNAEL SPDAIKANSM ELTAGSVDTT VFPLLMTLFE LARNPNVQQA LRQESLAAAA SISEHPQKAT TELPLLRAAL KETLRLYPVG LFLERVASSD LVLQNYHIPA GTLVRVFLYS LGRNPALFPR PERYNPQRWL DIRGSGRNFY HVPFGFGMRQ CLGRRLAEAE MLLLLHHVLK HLQVETLTQE DIKMVYSFIL RPSMFPLLTF RAIN
Target Information
The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CYP11B1; CYPXIB1; Cytochrome P-450c11; Cytochrome P450 11B1, mitochondrial; cytochrome p450 XIB1; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; Cytochrome P450C11; DKFZp686B05283; FLJ36771; P450C 11; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B1; steroid 11-beta-monooxygenase
Gene Aliases: CPN1; CYP11B; CYP11B1; FHI; P450C11; S11BH
UniProt ID: (Human) P15538
Entrez Gene ID: (Human) 1584
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
immune response
cholesterol metabolic process
regulation of blood pressure
sterol metabolic process
aldosterone biosynthetic process
cellular response to hormone stimulus
cortisol biosynthetic process
cellular response to potassium ion
glucose homeostasis
secondary metabolite biosynthetic process
oxidation-reduction process
cellular response to peptide hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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