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Invitrogen
CYP11B1/CYP11B2 Polyclonal Antibody
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Product Details
PA5-106795
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CYP11B1(Accession P15538), corresponding to amino acid residues K6-T26.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2854463
Product Specific Information
Antibody detects endogenous levels of total Cytochrome P450 11B1/2.
Target Information
The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; Corticosterone 18-monooxygenase, CYP11B2; CYP11B1; CYPXIB1; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450c11; Cytochrome P-450C18; Cytochrome P450 11B1, mitochondrial; Cytochrome P450 11B2, mitochondrial; cytochrome p450 XIB1; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; Cytochrome P450C11; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B1; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
Gene Aliases: ALDOS; CPN1; CPN2; CYP11B; CYP11B1; CYP11B2; CYP11BL; CYPXIB2; FHI; P-450C18; P450aldo; P450C11; P450C18; S11BH
UniProt ID: (Human) P15538, (Human) P19099
Entrez Gene ID: (Human) 1584, (Human) 1585
steroid 11-beta-monooxygenase activity
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
heme binding
corticosterone 18-monooxygenase activity
steroid hydroxylase activity
regulation of blood volume by renal aldosterone
renal water homeostasis
C21-steroid hormone biosynthetic process
mineralocorticoid biosynthetic process
cholesterol metabolic process
sterol metabolic process
aldosterone biosynthetic process
cellular response to hormone stimulus
cortisol biosynthetic process
cellular response to potassium ion
secondary metabolite biosynthetic process
potassium ion homeostasis
sodium ion homeostasis
oxidation-reduction process
cellular response to peptide hormone stimulus
glucocorticoid biosynthetic process
immune response
regulation of blood pressure
glucose homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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