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Product Details
BS-10161R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CYP11B2, amino acids 251-350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; Corticosterone 18-monooxygenase, CYP11B2; CYPXIB2; CYPXIB3; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450 11B2, mitochondrial; cytochrome P450 11B3, mitochondrial; Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase); cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily 11B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; Cytochrome P450C11; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P-450C 18; P450-Aldo-1; P450-Aldo-2; P450C 18; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo; steroid-11-beta-hydroxylase
Gene Aliases: ALDOS; Cp45as; CPN2; CYP11B; Cyp11b-2; CYP11B2; Cyp11b3; CYP11BL; CYPXIB2; P-450C18; P450aldo; P450C18; RNCP45AS
UniProt ID: (Human) P19099, (Mouse) P15539
Entrez Gene ID: (Human) 1585, (Mouse) 13072, (Rat) 24294
steroid 11-beta-monooxygenase activity
iron ion binding
steroid hydroxylase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
heme binding
corticosterone 18-monooxygenase activity
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
metal ion binding
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
regulation of blood volume by renal aldosterone
steroid biosynthetic process
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
regulation of blood pressure
aldosterone biosynthetic process
cortisol biosynthetic process
drinking behavior
positive regulation of blood pressure
ion homeostasis
oxidation-reduction process
response to nutrient
response to salt stress
cellular response to nutrient
response to insulin
cellular response to hormone stimulus
cellular response to potassium ion
response to drug
response to peptide hormone
cellular response to potassium ion starvation
potassium ion homeostasis
sodium ion homeostasis
cellular response to mechanical stimulus
cellular response to peptide hormone stimulus
renal water homeostasis
mineralocorticoid biosynthetic process
cholesterol metabolic process
sterol metabolic process
secondary metabolite biosynthetic process
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