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Invitrogen
CYP17A1 Polyclonal Antibody
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CYP17A1 Antibody (PA5-120237) in WB
Western blot analysis of CYP17A1 in extracts of Rat testis. Samples were incubated with CYP17A1 Polyclonal antibody (Product # PA5-120237) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-120237
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human CYP17A1 (NP_000093.1).
Conjugate
Form
Liquid
Concentration
1.49 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913809
Product Specific Information
Positive test controls include: Rat testis. The target is usually found in the following locations: Membrane.
Immunogen sequence: LSKDSLVDLV PWLKIFPNKT LEKLKSHVKI RNDLLNKILE NYKEKFRSDS ITNMLDTLMQ AKMNSDNGNA GPDQDSELLS DNHILTTIGD IFGAGVETTT SVVKWTLAFL LHNPQVKKKL YEEIDQNVGF SRTPTISDRN RLLLLEATIR EVLRLRPVAP MLIPHKANVD SSIGEFAVDK GTEVIINLWA LHHNEKEWHQ PDQFMPERFL NPAGTQLISP SVSYLPFGAG PRSCIGEILA RQELFLIMAW LLQRFDLEVP DDGQLPSLEG IPKVVFLIDS FKVKIKVRQA WREAQAEGST
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17-alpha-hydroxyprogesterone aldolase; 17a-hydroxylase; CYPXVII; Cytochrome P450 17A1; cytochrome p450 XVIIA1; cytochrome P450, 17; cytochrome P450, 17a1; cytochrome P450, family 17, subfamily A, polypeptide 1; cytochrome P450, subfamily 17; Cytochrome P450, subfamily XVII; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; Cytochrome P450-C17; Cytochrome P450c17; HGNC:2593; P450-C17; P45017alpha; P450c17; steroid 17-alpha hydroxylase; Steroid 17-alpha-hydroxylase/17,20 lyase; Steroid 17-alpha-monooxygenase
Gene Aliases: CPT7; CYP17; CYP17A1; P450C17; S17AH
UniProt ID: (Human) P05093, (Mouse) P27786, (Rat) P11715
Entrez Gene ID: (Human) 1586, (Mouse) 13074, (Rat) 25146
steroid 17-alpha-monooxygenase activity
iron ion binding
oxygen binding
heme binding
17-alpha-hydroxyprogesterone aldolase activity
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
lyase activity
metal ion binding
steroid biosynthetic process
glucocorticoid biosynthetic process
steroid metabolic process
hormone biosynthetic process
progesterone metabolic process
oxidation-reduction process
positive regulation of steroid hormone biosynthetic process
androgen biosynthetic process
sex differentiation
response to herbicide
response to acetate
response to ionizing radiation
sterol metabolic process
response to insecticide
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
phthalate metabolic process
hippocampus development
adrenal gland development
ovulation
response to nutrient levels
response to retinoic acid
Leydig cell differentiation
response to cytokine
response to drug
response to steroid hormone
response to cAMP
response to methylmercury
response to fungicide
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to gonadotropin stimulus
organic acid metabolic process
male gonad development
response to toxic substance
response to organic substance
response to organic cyclic compound
response to gonadotropin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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