Proteintech

CYP1A1 Polyclonal Antibody

CYP1A1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 11

CYP1A1 Antibody (13241-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 13241-1-AP (CYP1A1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CYP1A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CYP1A1 Antibody in Flow Cytometry (Flow)

CYP1A1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13241-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 46 publications 46 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 6 publications 6 publications

Flow Cytometry (Flow)

0.5 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CYP1A1 Fusion Protein Ag3990 (115-465 aa encoded by BC023019)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ISNGQSMSF SPDSGPVWAA RRRLAQNGLK SFSIASDPAS STSCYLEEHV SKEAEVLIST LQELMAGPGH FNPYRYVVVS VTNVICAICF GRRYDHNHQE LLSLVNLNNN FGEVVGSGNP ADFIPILRYL PNPSLNAFKD LNEKFYSFMQ KMVKEHYKTF EKGHIRDITD SLIEHCQEKQ LDENANVQLS DEKIINIVLD LFGAGFDTVT TAISWSLMYL VMNPRVQRKI QEELDTVIGR SRRPRLSDRS HLPYMEAFIL ETFRHSSFVP FTIPHSTTRD TSLKGFYIPK GRCVFVNQWQ INHDQKLWVN PSEFLPERFL TPDGAIDKVL SEKVIIFGMG KRKCIGETIA RW (115-465 aa encoded by BC023019)

Target Information

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Tue Oct 01 00:00:00 UTC 2019

CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Sonawane VR,Siddique MUM,Gatchie L,Williams IS,Bharate SB,Jayaprakash V,Sinha BN,Chaudhuri B

Mon Apr 01 00:00:00 UTC 2019

Aryl hydrocarbon receptor activation maintained the intestinal epithelial barrier function through Notch1 dependent signaling pathway.

International journal of molecular medicine

Liu Z,Li L,Chen W,Wang Q,Xiao W,Ma Y,Sheng B,Li X,Sun L,Yu M,Yang H

Thu Mar 01 00:00:00 UTC 2018

Aryl hydrocarbon receptor activation maintained the intestinal epithelial barrier function through Notch1 dependent signaling pathway.

International journal of molecular medicine

Liu Z,Li L,Chen W,Wang Q,Xiao W,Ma Y,Sheng B,Li X,Sun L,Yu M,Yang H

Thu Mar 01 00:00:00 UTC 2018

Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.

Bioorganic & medicinal chemistry

Sharma R,Williams IS,Gatchie L,Sonawane VR,Chaudhuri B,Bharate SB

Sat Dec 15 00:00:00 UTC 2018

Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.

Bioorganic & medicinal chemistry

Sharma R,Williams IS,Gatchie L,Sonawane VR,Chaudhuri B,Bharate SB

Sat Dec 15 00:00:00 UTC 2018

Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.

International journal of molecular medicine

Wang Q,Yang K,Han B,Sheng B,Yin J,Pu A,Li L,Sun L,Yu M,Qiu Y,Xiao W,Yang H

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6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression.

Chemico-biological interactions

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Fri May 25 00:00:00 UTC 2018

Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.

Biochemistry. Biokhimiia

Huang B,Bao J,Cao YR,Gao HF,Jin Y

Tue May 01 00:00:00 UTC 2018

Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity.

International journal of biological sciences

Yu M,Wang Q,Ma Y,Li L,Yu K,Zhang Z,Chen G,Li X,Xiao W,Xu P,Yang H

Tue Feb 12 00:00:00 UTC 2019

Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity.

International journal of biological sciences

Yu M,Wang Q,Ma Y,Li L,Yu K,Zhang Z,Chen G,Li X,Xiao W,Xu P,Yang H

Tue Feb 12 00:00:00 UTC 2019

Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.

ACS omega

Sharma R,Williams IS,Gatchie L,Sonawane VR,Chaudhuri B,Bharate SB

Fri Aug 31 00:00:00 UTC 2018

Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes.

International journal of molecular medicine

Liu Q,Wu J,Song J,Liang P,Zheng K,Xiao G,Liu L,Zouboulis CC,Lei T

Sun Oct 01 00:00:00 UTC 2017

Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes.

International journal of molecular medicine

Liu Q,Wu J,Song J,Liang P,Zheng K,Xiao G,Liu L,Zouboulis CC,Lei T

Sun Oct 01 00:00:00 UTC 2017

Hydroxylation and sulfation of sex steroid hormones in inflammatory liver.

Journal of biomedical research

Lee SR,Lee SY,Kim SY,Ryu SY,Park BK,Hong EJ

Tue Sep 26 00:00:00 UTC 2017

The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.

Cell biology international

Yin J,Sheng B,Han B,Pu A,Yang K,Li P,Wang Q,Xiao W,Yang H

Sun May 01 00:00:00 UTC 2016

The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.

Cell biology international

Yin J,Sheng B,Han B,Pu A,Yang K,Li P,Wang Q,Xiao W,Yang H

Sun May 01 00:00:00 UTC 2016

Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells.

Digestive diseases and sciences

Yin J,Sheng B,Pu A,Han B,Yang K,Wang Q,Sun L,Yang H

Mon Feb 01 00:00:00 UTC 2016

Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.

Toxins

Zhang B,Liu Y,Li X

Mon Mar 30 00:00:00 UTC 2015

Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.

Toxins

Zhang B,Liu Y,Li X

Mon Mar 30 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: aromatic compound inducible; aryl hydrocarbon hydroxylase; CYP; CYPIA1; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; cytochrome P450 family 1 subfamily a polypeptide 2; Cytochrome P450 form 6; cytochrome P450 subfamily I, polypeptide 1; cytochrome P450, 1a1, aromatic compound inducible; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; P450; P450 form 6; P450-P1; xenobiotic monooxygenase

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Gene Aliases: AHH; AHRR; CP11; CYP1; Cyp1a-1; CYP1A1; Cyp1a2; CYPIA1; P1-450; P450-1; P450-C; P450DX

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UniProt ID: (Human) P04798, (Mouse) P00184

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Entrez Gene ID: (Human) 1543, (Pig) 403103, (Mouse) 13076

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Function(s)

monooxygenase activity iron ion binding protein binding steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on diphenols and related substances as donors flavonoid 3'-monooxygenase activity oxygen binding enzyme binding heme binding demethylase activity aromatase activity vitamin D 24-hydroxylase activity catalytic activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen metal ion binding

Process(es)

response to hypoxia porphyrin-containing compound metabolic process aging cell proliferation amine metabolic process response to wounding response to virus response to nematode response to herbicide ethylene metabolic process embryo development ending in birth or egg hatching coumarin metabolic process flavonoid metabolic process response to iron(III) ion insecticide metabolic process drug metabolic process dibenzo-p-dioxin catabolic process epoxygenase P450 pathway response to food response to lipopolysaccharide response to vitamin A response to immobilization stress vitamin D metabolic process response to drug 9-cis-retinoic acid biosynthetic process camera-type eye development response to antibiotic response to arsenic-containing substance digestive tract development hydrogen peroxide biosynthetic process response to hyperoxia oxidation-reduction process maternal process involved in parturition hepatocyte differentiation demethylation cellular response to organic cyclic compound omega-hydroxylase P450 pathway positive regulation of G1/S transition of mitotic cell cycle toxin metabolic process response to toxic substance dibenzo-p-dioxin metabolic process heterocycle metabolic process

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CYP1A1 Polyclonal Antibody

CYP1A1 Antibody (13241-1-AP) in ICC/IF

Product Details

13241-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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