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OriGene
CYP1A2 Monoclonal Antibody (OTI1H3), TrueMAB™
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Product Details
CF501154
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1H3
Immunogen
Full length human recombinant protein of human CYP1A2 produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aryl hydrocarbon hydroxylase; Cholesterol 25-hydroxylase; CYP; CYPIA2; Cytochrome P(3)450; Cytochrome P450 1A2; Cytochrome P450 4; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; Cytochrome P450-P3; dioxin-inducible P3-450; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P(3)450; P450; P450 4; P450 form 4; P450-P3; xenobiotic monooxygenase
Gene Aliases: CP12; CYP1A2; P3-450; P450(PA)
UniProt ID: (Human) P05177
Entrez Gene ID: (Human) 1544
monooxygenase activity
iron ion binding
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
enzyme binding
heme binding
demethylase activity
caffeine oxidase activity
aromatase activity
steroid catabolic process
porphyrin-containing compound metabolic process
xenobiotic metabolic process
toxin biosynthetic process
post-embryonic development
alkaloid metabolic process
regulation of gene expression
monoterpenoid metabolic process
drug metabolic process
dibenzo-p-dioxin metabolic process
epoxygenase P450 pathway
lung development
methylation
response to estradiol
response to lipopolysaccharide
monocarboxylic acid metabolic process
response to immobilization stress
drug catabolic process
exogenous drug catabolic process
cellular respiration
heterocycle metabolic process
hydrogen peroxide biosynthetic process
oxidation-reduction process
oxidative demethylation
cellular response to cadmium ion
oxidative deethylation
omega-hydroxylase P450 pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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