Invitrogen

CYP1B1 Polyclonal Antibody

1 Reference
View all (14) CYP1B1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-28040

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human CYP1B1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.63 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2545516

Product Specific Information

Recommended positive controls: 293T, mouse lung.

Predicted reactivity: Mouse (84%), Rat (84%), Dog (82%), Rhesus Monkey (94%), Bovine (82%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: aryl hydrocarbon hydroxylase; benz[a]anthracene inducible; CYPIB1; Cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); Cytochrome P450CMEF; Cytochrome P450EF; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; xenobiotic monooxygenase

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Gene Aliases: CP1B; Cyp1-b1; CYP1B1; CYPIB1; GLC3A; P4501B1

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UniProt ID: (Human) Q16678, (Mouse) Q64429

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Entrez Gene ID: (Human) 1545, (Mouse) 13078

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Function(s)
monooxygenase activity iron ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen oxygen binding heme binding aromatase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding
Process(es)
angiogenesis trabecular meshwork development DNA modification cellular aromatic compound metabolic process xenobiotic metabolic process nitric oxide biosynthetic process cell adhesion steroid metabolic process estrogen metabolic process negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress toxin metabolic process response to toxic substance positive regulation of vascular endothelial growth factor production positive regulation of smooth muscle cell migration dibenzo-p-dioxin metabolic process arachidonic acid metabolic process collagen fibril organization negative regulation of cell migration negative regulation of NF-kappaB transcription factor activity negative regulation of cell adhesion mediated by integrin benzene-containing compound metabolic process retinol metabolic process retinal metabolic process positive regulation of apoptotic process endothelial cell migration positive regulation of translation positive regulation of angiogenesis positive regulation of JAK-STAT cascade membrane lipid catabolic process blood vessel morphogenesis oxidation-reduction process retina vasculature development in camera-type eye retinal blood vessel morphogenesis cellular response to hydrogen peroxide cellular response to organic cyclic compound endothelial cell-cell adhesion regulation of reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process visual perception sterol metabolic process epoxygenase P450 pathway omega-hydroxylase P450 pathway
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