Invitrogen

CYP26A1 Polyclonal Antibody

View all (16) CYP26A1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-95729

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CYP26A1 (NP_0007742)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.58 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2807531

Product Specific Information

Immunogen sequence: GFPFFGETLQ MVLQRRKFLQ MKRRKYGFIY KTHLFGRPTV RVMGADNVRR ILLGEHRLVS VHWPASVRTI LGSGCLSNLH DSSHKQRKKV IMRAFSREAL E; Positive Samples: HepG2

Target Information

CYP26A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CYP26A1; Cytochrome P450 26A1; Cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, 26, retinoic acid A1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; Cytochrome P450RAI; hP450RAI; P450, retinoic acid-inactivating, 1; Retinoic acid 4-hydroxylase; retinoic acid hydrolase; Retinoic acid-metabolizing cytochrome

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Gene Aliases: CP26; CYP26; CYP26A1; P450RA; P450RAI; P450RAI1; RAH

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UniProt ID: (Human) O43174, (Mouse) O55127

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Entrez Gene ID: (Human) 1592, (Mouse) 13082

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Function(s)
retinoic acid binding iron ion binding retinoic acid 4-hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxygen binding heme binding monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen fluorene oxygenase activity mono-butyltin dioxygenase activity tri-n-butyltin dioxygenase activity di-n-butyltin dioxygenase activity methylsilanetriol hydroxylase activity methyl tertiary butyl ether 3-monooxygenase activity 4-nitrocatechol 4-monooxygenase activity 4-chlorophenoxyacetate monooxygenase activity tert-butanol 2-monooxygenase activity alpha-pinene monooxygenase activity dimethylsilanediol hydroxylase activity ammonia monooxygenase activity hydroxymethylsilanetriol oxidase activity 2-hydroxyisobutyrate 3-monooxygenase activity alpha-pinene dehydrogenase activity bisphenol A hydroxylase B activity 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity 9-fluorenone-3,4-dioxygenase activity anthracene 9,10-dioxygenase activity 2-(methylthio)benzothiazole monooxygenase activity 2-hydroxybenzothiazole monooxygenase activity benzothiazole monooxygenase activity 2,6-dihydroxybenzothiazole monooxygenase activity pinacolone 5-monooxygenase activity thioacetamide S-oxygenase activity thioacetamide S-oxide S-oxygenase activity endosulfan monooxygenase I activity N-nitrodimethylamine hydroxylase activity 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity endosulfan ether monooxygenase activity pyrene 4,5-monooxygenase activity pyrene 1,2-monooxygenase activity 1-hydroxypyrene 6,7-monooxygenase activity 1-hydroxypyrene 7,8-monooxygenase activity phenylboronic acid monooxygenase activity spheroidene monooxygenase activity metal ion binding
Process(es)
vitamin metabolic process xenobiotic metabolic process retinoic acid catabolic process retinoic acid metabolic process negative regulation of retinoic acid receptor signaling pathway oxidation-reduction process central nervous system development anterior/posterior pattern specification neural crest cell development retinoic acid receptor signaling pathway
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