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Invitrogen
CYP3A4 Recombinant Rabbit Monoclonal Antibody (10B10)
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CYP3A4 Antibody (MA5-49856) in IHC (P)
Immunohistochemistry analysis with a CYP3A4 monoclonal antibody (Product # MA5-49856) using a dilution of 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% BSA) was incub... View More
Product Details
MA5-49856
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
10B10
Immunogen
A synthesized peptide derived from human Cytochrome P450 3A4
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3092723
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; Albendazole monooxygenase (sulfoxide-forming); Albendazole sulfoxidase; Cholesterol 25-hydroxylase; CYP; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 3A4; Cytochrome P450 HLp; Cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; Cytochrome P450-PCN1; glucocorticoid-inducible P450; MGC126680; Nifedipine oxidase; P450; P450-III, steroid inducible; P450-PCN1; Quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase
Gene Aliases: CP33; CP34; CYP3A; CYP3A3; CYP3A4; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1
UniProt ID: (Human) P08684
Entrez Gene ID: (Human) 1576
monooxygenase activity
steroid binding
iron ion binding
steroid hydroxylase activity
oxidoreductase activity
oxygen binding
enzyme binding
heme binding
vitamin D3 25-hydroxylase activity
taurochenodeoxycholate 6alpha-hydroxylase activity
caffeine oxidase activity
albendazole monooxygenase activity
quinine 3-monooxygenase activity
testosterone 6-beta-hydroxylase activity
aromatase activity
vitamin D 24-hydroxylase activity
lipid metabolic process
steroid catabolic process
xenobiotic metabolic process
steroid metabolic process
androgen metabolic process
alkaloid catabolic process
monoterpenoid metabolic process
drug metabolic process
calcitriol biosynthetic process from calciol
vitamin D metabolic process
drug catabolic process
exogenous drug catabolic process
heterocycle metabolic process
oxidation-reduction process
oxidative demethylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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