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CYP4A11 Polyclonal Antibody

CYP4A11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CYP4A11 Antibody (11688-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney tissue slide using 11688-1-AP (CYP4A11 antibody) at dilution of 1:1000 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

11688-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:300-1:1,000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CYP4A11 Fusion Protein Ag2300 (1-215 aa encoded by BC022851)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSVSVLSPS RLLGDVSGIL QAASLLILLL LLIKAVQLYL HRQWLLKALQ QFPCPPSHWL FGHIQELQQD QELQRIQKWV ETFPSACPHW LWGGKVRVQL YDPDYMKVIL GRSDPKSHGS YRFLAPWIGY GLLLLNGQTW FQHRRMLTPA FHYDILKPYV GLMADSVRVM LDKWEELLGQ DSPLEVFQHV SLMTLDTIMK CAFRHWQRAQ HSRHLP (1-215 aa encoded by B C022851)

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase.

Free radical biology & medicine

Chen X,Xu Y,Denning KL,Grigore A,Lu Y

Tue Jun 01 00:00:00 UTC 2021

Identification of the miRNA-3185/CYP4A11 axis in cardiac tissue as a biomarker for mechanical asphyxia.

Forensic science international

Han L,Zhang H,Zeng Y,Lv Y,Tao L,Ma J,Xu H,Ma K,Shi Q,Xiao B,Chen L

Mon Jun 01 00:00:00 UTC 2020

Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy.

Chemico-biological interactions

Ding S,Qiu H,Huang J,Chen R,Zhang J,Huang B,Zou X,Cheng O,Jiang Q

Mon Jul 01 00:00:00 UTC 2019

Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Food & function

Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

Thu Aug 01 00:00:00 UTC 2019

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Food & function

Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

Mon Dec 01 00:00:00 UTC 2014

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Food & function

Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

Mon Dec 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; alkane-1 monooxygenase; CYP4AII; CYPIVA11; CYPIVA2; Cytochrome P-450 K-2; Cytochrome P-450HK-omega; Cytochrome P450 4A11; Cytochrome P450 4A2; Cytochrome P450 K-5; cytochrome P450, family 4, subfamily A, polypeptide 11; cytochrome P450, subfamily 4A, polypeptide 11; cytochrome P450, subfamily IVA, polypeptide 11; Cytochrome P450-LA-omega 2; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase; Long-chain fatty acid omega-monooxygenase; P-450 HK omega; P-450 IV4AII; P-450 K-2; P450 K-5; P450-HL-omega; P450-LA-omega 2; P450HL-omega

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Gene Aliases: CP4Y; Cyp4a-2; CYP4A11; CYP4A2; CYP4AII

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UniProt ID: (Human) Q02928, (Rat) P20816

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Entrez Gene ID: (Human) 1579, (Rat) 24306

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Function(s)

monooxygenase activity iron ion binding arachidonic acid epoxygenase activity alkane 1-monooxygenase activity oxygen binding heme binding leukotriene-B4 20-monooxygenase activity fatty acid binding arachidonic acid monooxygenase activity arachidonic acid 11,12-epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen arachidonic acid binding arachidonic acid omega-hydroxylase activity

Process(es)

kidney development response to hormone arachidonic acid metabolic process response to drug linoleic acid metabolic process icosanoid biosynthetic process lauric acid metabolic process oxidation-reduction process long-chain fatty acid metabolic process renal water homeostasis pressure natriuresis fatty acid metabolic process leukotriene metabolic process epoxygenase P450 pathway positive regulation of icosanoid secretion leukotriene B4 catabolic process sodium ion homeostasis omega-hydroxylase P450 pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CYP4A11 Polyclonal Antibody

CYP4A11 Antibody (11688-1-AP) in IHC (P)

Product Details

11688-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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