Invitrogen

CaMKII beta/gamma Polyclonal Antibody

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View all (2) CaMKII beta/gamma antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-36195

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:200
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 601-652of human CaMKII beta
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2553410

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 50-80 kDa.

Purity is >95% by SDS-PAGE.

Target Information

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be coexpressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Ca++/calmodulin-dependent protein kinase II beta subunit; Ca2+/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase II gamma; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II gamma chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II beta subunit; CaM kinase II subunit beta; CaM kinase II subunit gamma; CaM-kinase II beta chain; caM-kinase II gamma chain; CaMK II; caMK-II subunit beta; caMK-II subunit gamma; proline rich calmodulin-dependent protein kinase

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Gene Aliases: CAM2; CAMK; CAMK-II; CAMK2; CAMK2B; Camk2d; CAMK2G; CAMKB; CAMKG; Ck2b

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UniProt ID: (Human) Q13554, (Human) Q13555, (Rat) P08413, (Mouse) P28652, (Mouse) Q923T9, (Rat) P11730

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Entrez Gene ID: (Human) 816, (Human) 818, (Rat) 24245, (Mouse) 12323, (Mouse) 12325, (Rat) 171140

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Function(s)
actin binding protein serine/threonine kinase activity calmodulin-dependent protein kinase activity Ras guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding protein kinase binding protein homodimerization activity phospholipase binding calcium-dependent protein serine/threonine phosphatase activity nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
G1/S transition of mitotic cell cycle MAPK cascade protein dephosphorylation calcium ion transport nervous system development regulation of skeletal muscle adaptation insulin secretion cell differentiation positive regulation of GTPase activity protein autophosphorylation protein oligomerization regulation of calcium ion transport interferon-gamma-mediated signaling pathway regulation of cellular response to heat regulation of relaxation of cardiac muscle protein phosphorylation signal transduction positive regulation of neuron projection development positive regulation of phospholipase A2 activity regulation of long-term neuronal synaptic plasticity cell projection morphogenesis regulation of synapse structural plasticity regulation of dendritic spine development positive regulation of dendritic spine morphogenesis positive regulation of synapse maturation inhibitory G-protein coupled receptor phosphorylation peptidyl-serine phosphorylation regulation of synaptic transmission, cholinergic response to cadmium ion neuromuscular process controlling balance long-term synaptic potentiation activation of meiosis involved in egg activation positive regulation of apoptotic signaling pathway phosphorylation response to hypoxia response to oxidative stress multicellular organism development
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