Proteintech

CaMKII gamma Polyclonal Antibody

CaMKII gamma Antibody in Immunocytochemistry (ICC/IF)

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CaMKII gamma Antibody (12666-2-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using CAMK2G antibody 12666-2-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

CaMKII gamma Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CaMKII gamma Antibody in Western Blot (WB)

CaMKII gamma Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12666-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CaMKII gamma Fusion Protein Ag3348 (218-527 aa encoded by BC034044)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can bind all the CAMK2s for the close sequences.

Immunogen sequence: DQHKLYQQI KAGAYDFPSP EWDTVTPEAK NLINQMLTIN PAKRITADQA LKHPWVCQRS TVASMMHRQE TVECLRKFNA RRKLKGAILT TMLVSRNFSV GRQSSAPASP AASAAGLAGQ AAKSLLNKKS DGGVKKRKSS SSVHLMEPQT TVVHNATDGI KGSTESCNTT TEDEDLKVRK QEIIKITEQL IEAINNGDFE AYTKICDPGL TSFEPEALGN LVEGMDFHKF YFENLLSKNS KPIHTTILNP HVHVIGEDAA CIAYIRLTQY IDGQGRPRTS QSEETRVWHR RDGKWLNVHY HCSGAPAAPL Q (218-527 aa encoded by BC034044)

Target Information

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Immunohistochemical distribution of Ca²⁺/calmodulin-dependent protein kinase II subunits in the rat carotid body.

Acta histochemica

Saito H,Yokoyama T,Nakamuta N,Yamamoto Y

Mon May 01 00:00:00 UTC 2023

Orally administered sodium nitrite prevents the increased α-1 adrenergic vasoconstriction induced by hypertension and promotes the S-nitrosylation of calcium/calmodulin-dependent protein kinase II.

Biochemical pharmacology

Oliveira-Paula GH,I M Batista R,Stransky S,Tella SC,Ferreira GC,Portella RL,Pinheiro LC,Damacena-Angelis C,Riascos-Bernal DF,Sidoli S,Sibinga N,Tanus-Santos JE

Thu Jun 01 00:00:00 UTC 2023

The delta subunit of the GABA_A receptor is necessary for the GPT2-promoted breast cancer metastasis.

Theranostics

Li N,Xu X,Liu D,Gao J,Gao Y,Wu X,Sheng H,Li Q,Mi J

Tue Mar 21 00:00:00 UTC 2023

Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.

Signal transduction and targeted therapy

Zhang P,He Q,Wang Y,Zhou G,Chen Y,Tang L,Zhang Y,Hong X,Mao Y,He Q,Yang X,Liu N,Ma J

Wed Feb 16 00:00:00 UTC 2022

Evaluation of the synergistic effects of epigallocatechin-3-gallate-loaded PEGylated-PLGA nanoparticles with nimodipine against neuronal injury after subarachnoid hemorrhage.

Frontiers in nutrition

Yang X,Han M,Wang X,Wang J,Sun X,Zhang C,Yan S,Huang L,Chen Y

Wed Feb 01 00:00:00 UTC 2023

Azoramide ameliorated tachypacing-induced injury of atrial myocytes differentiated from human induced pluripotent stem cell by regulating endoplasmic reticulum stress.

Stem cell research

Miao W,Shi J,Huang J,Lin Y,Cui C,Zhu Y,Zheng B,Li M,Jiang Q,Chen M

Fri Apr 01 00:00:00 UTC 2022

Wnt5a protects motor neurons in amyotrophic lateral sclerosis by regulating the Wnt/Ca²⁺ signaling pathway.

American journal of translational research

Liu J,Zhou F,Chen Y,Guan Y,Meng F,Zhao Z,Wang X,Gao X,Jiang X,Zhang H,Wang Q,Zhou S,Wang X

Sat Sep 17 00:00:00 UTC 2022

Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling.

The Journal of biological chemistry

Yan Q,Gao H,Yao Q,Ling K,Xiao G

Tue Mar 01 00:00:00 UTC 2022

RIP3 facilitates necroptosis through CaMKII and AIF after intracerebral hemorrhage in mice.

Neuroscience letters

Xu Y,Wu X,Hu W,Yu D,Shao Z,Li W,Huang T,Zhang J,Zhu X,Li X,Yang H,Chu Z,Lv K

Thu Apr 01 00:00:00 UTC 2021

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca²⁺/CaMKII/Nrf2 signaling pathway.

Cell death & disease

Lv Z,Xu X,Sun Z,Yang YX,Guo H,Li J,Sun K,Wu R,Xu J,Jiang Q,Ikegawa S,Shi D

Tue May 18 00:00:00 UTC 2021

CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis.

Aging

Yang L,Wu B,Wu Z,Xu Y,Wang P,Li M,Xu R,Liang Y

Mon Jul 13 00:00:00 UTC 2020

CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis.

Aging

Yang L,Wu B,Wu Z,Xu Y,Wang P,Li M,Xu R,Liang Y

Mon Jul 13 00:00:00 UTC 2020

Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression.

Cell communication and signaling : CCS

Liu Q,Yang C,Wang S,Shi D,Wei C,Song J,Lin X,Dou R,Bai J,Xiang Z,Huang S,Liu K,Xiong B

Mon Mar 30 00:00:00 UTC 2020

Pin1 Is Regulated by CaMKII Activation in Glutamate-Induced Retinal Neuronal Regulated Necrosis.

Frontiers in cellular neuroscience

Wang S,Liao L,Huang Y,Wang M,Zhou H,Chen D,Liu F,Ji D,Xia X,Jiang B,Huang J,Xiong K

Wed Sep 30 00:00:00 UTC 2020

JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.

Neuron

Berg JM,Lee C,Chen L,Galvan L,Cepeda C,Chen JY,Peñagarikano O,Stein JL,Li A,Oguro-Ando A,Miller JA,Vashisht AA,Starks ME,Kite EP,Tam E,Gdalyahu A,Al-Sharif NB,Burkett ZD,White SA,Fears SC,Levine MS,Wohlschlegel JA,Geschwind DH

Wed Dec 16 00:00:00 UTC 2015

JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.

Neuron

Wed Dec 16 00:00:00 UTC 2015

PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of Stathmin1.

Oncotarget

Li C,Zhou X,Chen J,Lu Y,Sun Q,Tao D,Hu W,Zheng X,Bian S,Liu Y,Ma Y

Tue Sep 29 00:00:00 UTC 2015

PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of Stathmin1.

Oncotarget

Li C,Zhou X,Chen J,Lu Y,Sun Q,Tao D,Hu W,Zheng X,Bian S,Liu Y,Ma Y

Tue Sep 29 00:00:00 UTC 2015

iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.

Proteomics

Chen H,Xu L,Yin L,Xu Y,Han X,Qi Y,Zhao Y,Liu K,Peng J

Wed Jan 01 00:00:00 UTC 2014

iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.

Proteomics

Chen H,Xu L,Yin L,Xu Y,Han X,Qi Y,Zhao Y,Liu K,Peng J

Wed Jan 01 00:00:00 UTC 2014

Calmodulin-dependent protein kinase gamma 3 (CamKIIgamma3) mediates the cell cycle resumption of metaphase II eggs in mouse.

Development (Cambridge, England)

Chang HY,Minahan K,Merriman JA,Jones KT

Tue Dec 01 00:00:00 UTC 2009

Calmodulin-dependent protein kinase gamma 3 (CamKIIgamma3) mediates the cell cycle resumption of metaphase II eggs in mouse.

Development (Cambridge, England)

Chang HY,Minahan K,Merriman JA,Jones KT

Tue Dec 01 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: Ca2+/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II gamma; calcium/calmodulin-dependent protein kinase type II gamma chain; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; caM-kinase II gamma chain; CAM2; CaMK II; caMK-II subunit gamma; CAMK2; CAMK2B; CAMK2D; CAMKB; CAMKD

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Gene Aliases: CAMK; CAMK-II; CAMK2G; CAMKG

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UniProt ID: (Human) Q13555, (Mouse) Q923T9, (Rat) P11730

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Entrez Gene ID: (Human) 818, (Mouse) 12325, (Rat) 171140

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Function(s)

protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calcium-dependent protein serine/threonine phosphatase activity Ras guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding protein homodimerization activity nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

G1/S transition of mitotic cell cycle MAPK cascade protein dephosphorylation calcium ion transport nervous system development regulation of skeletal muscle adaptation insulin secretion cell differentiation positive regulation of GTPase activity protein autophosphorylation protein oligomerization regulation of calcium ion transport interferon-gamma-mediated signaling pathway regulation of cellular response to heat regulation of relaxation of cardiac muscle response to hypoxia protein phosphorylation response to oxidative stress multicellular organism development phosphorylation regulation of long-term neuronal synaptic plasticity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CaMKII gamma Polyclonal Antibody

CaMKII gamma Antibody (12666-2-AP) in ICC/IF

Product Details

12666-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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