Alomone Labs, LTD

CaV1.2 (CACNA1C) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ACC-003-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)TTKINMDDLQPSENEDKS, corresponding to amino acid residues 848-865 of rat CaV1.2, Intracellular loop between domains II and III
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain class C; CACH3; CACN4; CACNA 1D; CACNL1A2; calcium channel voltage-dependent alpha1c subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; DHP receptor; DHPR, alpha-1 subunit; L-type calcium channel alpha-1 subunit; long-NT; LTCC; MBC; MELC-CC; MGC120730; Mouse brain class C; neuronal voltage-gated calcium channel alpha 1C subunit; Rat brain class C; RBC; skeletal muscle-specific calcium channel; voltage-dependent L-type Ca2+ channel alpha 1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*

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Gene Aliases: CACH2; CACN2; CACNA1C; CACNL1A1; CaV1.2; CCHL1A1; D930026N18Rik; LQT8; MBC; MELC-CC; RATIVS302; TS

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UniProt ID: (Human) Q13936, (Mouse) Q01815, (Rat) P22002

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Entrez Gene ID: (Human) 775, (Mouse) 12288, (Rat) 24239

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Function(s)
voltage-gated calcium channel activity protein binding calmodulin binding high voltage-gated calcium channel activity metal ion binding alpha-actinin binding voltage-gated calcium channel activity involved in cardiac muscle cell action potential voltage-gated calcium channel activity involved in AV node cell action potential ion channel activity voltage-gated ion channel activity calcium channel activity enzyme binding protein domain specific binding ion channel binding protein phosphatase 2A binding
Process(es)
immune system development positive regulation of cytosolic calcium ion concentration heart development regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion embryonic forelimb morphogenesis calcium-mediated signaling using extracellular calcium source camera-type eye development regulation of insulin secretion calcium ion transport into cytosol cardiac conduction calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane depolarization during cardiac muscle cell action potential membrane depolarization during AV node cell action potential cell communication by electrical coupling involved in cardiac conduction regulation of heart rate by cardiac conduction regulation of ventricular cardiac muscle cell action potential membrane depolarization during atrial cardiac muscle cell action potential transport ion transport calcium ion transport cellular calcium ion homeostasis smooth muscle contraction chemical synaptic transmission adult walking behavior regulation of blood pressure visual learning calcium ion regulated exocytosis regulation of vasoconstriction insulin secretion growth hormone secretion regulation of ion transmembrane transport glucose homeostasis regulation of organ growth transmembrane transport smooth muscle contraction involved in micturition calcium ion import membrane depolarization during action potential
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