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Invitrogen
CaV1.3 Polyclonal Antibody
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Product Details
PA5-118794
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CACNA1D(Accession Q01668), corresponding to amino acid residues L1088-I1138.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2903294
Product Specific Information
Antibody detects endogenous levels of total CACNA1D.
Target Information
CACNA1D is also known as PASNA, SANDD or Cav1. 3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain class D; CACNA 1D; calcium channel alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide isoform 2; Calcium channel, L type, alpha-1 polypeptide, isoform 2; calcium channel, neuroendocrine/brain-type, alpha 1 subunit; calcium channel, voltage-dependent, L type, alpha 1D subunit; CaV1.3alpha1; RBD; voltage-dependent calcium channel subunit alpha1D; Voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel alpha 1 subunit; voltage-gated calcium channel alpha subunit Cav1.3; voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker; Voltage-gated calcium channel subunit alpha Cav1.3
Gene Aliases: 8430418G19Rik; C79217; CACH3; CACN4; CACNA1D; CACNL1A2; Cav1.3; Cchl1a; CCHL1A2; D-LTCC; PASNA; SANDD
UniProt ID: (Human) Q01668, (Mouse) Q99246
Entrez Gene ID: (Human) 776, (Mouse) 12289, (Rat) 29716
voltage-gated calcium channel activity
high voltage-gated calcium channel activity
ankyrin binding
metal ion binding
alpha-actinin binding
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
protein binding
PDZ domain binding
calcium ion transport
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
sensory perception of sound
regulation of insulin secretion
positive regulation of calcium ion transport
regulation of atrial cardiac muscle cell membrane repolarization
cardiac conduction
calcium ion import
calcium ion transmembrane transport
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
regulation of potassium ion transmembrane transporter activity
regulation of potassium ion transmembrane transport
heart development
aging
memory
calcium-mediated signaling
positive regulation of CREB transcription factor activity
regulation of ion transmembrane transport
regulation of calcium ion transport
divalent metal ion transport
membrane depolarization during action potential
membrane repolarization during SA node cell action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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