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Product Details
PA5-120102
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1890-2030 of human CACNA1H (NP_066921.2).
Conjugate
Form
Liquid
Concentration
1.22 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913674
Product Specific Information
Positive test controls include: Mouse heart, Rat testis, Rat heart. The target is usually found in the following locations: Membrane, Multi-pass membrane protein.
Immunogen sequence: SARRVDADRP PLPQESPGAR DAPNLVARKV SVSRMLSLPN DSYMFRPVVP ASAPHPRPLQ EVEMETYGAG TPLGSVASVH SPPAESCASL QIPLAVSSPA RSGEPLHALS PRGTARSPSL SRLLCRQEAV HTDSLEGKID S
Target Information
This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A1H-b; calcium channel alpha13.2 subunit; FLJ90484; low-voltage-activated calcium channel alpha13.2 subunit; T-type Cav3.2; voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel subunit alpha Cav3.2
Gene Aliases: alpha13.2; Cav3.2; MNCb-1209
Entrez Gene ID: (Mouse) 58226
transport
ion transport
calcium ion transport
sensory perception of pain
aldosterone biosynthetic process
ion transmembrane transport
cortisol biosynthetic process
regulation of ion transmembrane transport
regulation of membrane potential
positive regulation of calcium ion-dependent exocytosis
transmembrane transport
calcium ion import
calcium ion transmembrane transport
membrane depolarization during action potential
positive regulation of acrosome reaction
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