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Invitrogen
Calcineurin A Polyclonal Antibody
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Calcineurin A Antibody (PA5-17446) in ICC/IF
Immunofluorescent analysis of Pan-Calcineurin A in Hela cells using a Pan-Calcineurin A polyclonal antibody (Product # PA5-17446) (green) showing cytoplasmic localization. Actin filaments are labeled with a fluorescent red phalloidin. DNA is labeled using a fluorescent blue dye.
Product Details
PA5-17446
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the carboxy-terminus of human Calcineurin A (alpha isoform)
Conjugate
Form
Liquid
Concentration
10 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10981308
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with protein phosphatase 1 or 2A.
Target Information
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Calcineurin A alpha; Calcineurin A1; Calcineurin subunit A alpha; CalcineurinA; Calmodulin-dependent calcineurin A subunit alpha isoform; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2B alpha 1; PP2BA alpha; PP2CB; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; Protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase-2Ba; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene Aliases: 2900074D19Rik; CALN; CALNA; CALNA1; CCN1; CN; CNA; CNA1; PPP2B; PPP3CA
UniProt ID: (Human) Q08209, (Mouse) P63328, (Rat) P63329
Entrez Gene ID: (Human) 5530, (Mouse) 19055, (Rat) 24674
protein serine/threonine phosphatase activity
calcium ion binding
protein binding
calmodulin binding
drug binding
enzyme binding
calmodulin-dependent protein phosphatase activity
protein heterodimerization activity
protein dimerization activity
phosphoprotein phosphatase activity
calcium-dependent protein serine/threonine phosphatase activity
hydrolase activity
metal ion binding
G1/S transition of mitotic cell cycle
protein dephosphorylation
protein import into nucleus
calcium ion transport
transition between fast and slow fiber
cardiac muscle hypertrophy in response to stress
dephosphorylation
calcium-mediated signaling
calcineurin-NFAT signaling cascade
multicellular organismal response to stress
negative regulation of chromatin binding
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
skeletal muscle fiber development
negative regulation of dendrite morphogenesis
modulation of synaptic transmission
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NFAT protein import into nucleus
response to calcium ion
excitatory postsynaptic potential
cellular response to glucose stimulus
positive regulation of cardiac muscle hypertrophy in response to stress
response to amphetamine
negative regulation of calcium ion-dependent exocytosis
Wnt signaling pathway, calcium modulating pathway
Fc-epsilon receptor signaling pathway
T cell activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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