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NeoBiotechnologies
Calcineurin B homologous protein 2/HCC Antigen 520 Monoclonal Antibody (CPTC-CHP2-1)
FIGURE: 1 / 3
Calcineurin B homologous protein 2/HCC Antigen 520 Antibody (63928-MSM1-P0) in ICC/IF
Immunofluorescence analysis of human MCF-7 cells labeling CHP2 with CHP2 Mouse Monoclonal Antibody (CPTC-CHP2-1) followed by Goat anti-mouse IgG-CF488 (Green).The nuclear counterstain is Reddot (Red).
Product Details
63928-MSM1-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2c, kappa
Class
Monoclonal
Type
Antibody
Clone
CPTC-CHP2-1
Immunogen
Recombinant human full-length CHP2 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Wet ice
Target Information
CHP2 (Calcineurin B homologous protein 2), also known as Hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains four EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcineurin B homologous protein 2; calcineurin-like EF hand protein 2; calcineurin-like EF-hand protein 2; hepatocellular carcinoma antigen gene 520; Hepatocellular carcinoma-associated antigen 520
Gene Aliases: CHP2; HCA520
UniProt ID: (Human) O43745
Entrez Gene ID: (Human) 63928
positive regulation of cell proliferation
positive regulation of phosphatase activity
protein transport
positive regulation of protein import into nucleus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of calcineurin-NFAT signaling cascade
cellular response to calcium ion
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