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Invitrogen
Calcium Channel beta-4 Polyclonal Antibody
Product Details
PA5-114705
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CACNB4(Accession O00305), corresponding to amino acid residues V488-L520.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899341
Product Specific Information
Antibody detects endogenous levels of total CACNB4.
Target Information
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAB4; calcium channel beta 4 subunit; Calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; OTTHUMP00000207247; OTTHUMP00000207249; Voltage-dependent L-type calcium channel subunit beta-4
Gene Aliases: 3110038O15Rik; CAB4; CACNB4; CACNLB4; Cchb4; EA5; EIG9; EJM; EJM4; EJM6; lh
UniProt ID: (Human) A8K1Y4, (Rat) D4A055, (Mouse) Q8R0S4
Entrez Gene ID: (Human) 785, (Rat) 58942, (Mouse) 12298
calcium ion transport
cellular calcium ion homeostasis
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
neuromuscular junction development
adult walking behavior
gamma-aminobutyric acid secretion
neuronal action potential propagation
T cell differentiation
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
regulation of membrane potential
cAMP metabolic process
spleen development
thymus development
Peyer's patch development
muscle fiber development
T cell receptor signaling pathway
neurological system process
detection of light stimulus involved in visual perception
synaptic transmission, GABAergic
calcium ion transmembrane transport
regulation of voltage-gated calcium channel activity
transport
membrane depolarization
cardiac conduction
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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