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Calcium Sensing Receptor Polyclonal Antibody

Calcium Sensing Receptor Antibody in Immunocytochemistry (ICC/IF)

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Calcium Sensing Receptor Antibody (19125-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using CASR antibody 19125-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

Calcium Sensing Receptor Antibody in Western Blot (WB)

Product Image Gallery

Product Details

19125-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

Assay-dependent

View 7 publications 7 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The 60-65 kDa band detected by this antibody might represent a degradation product of CASR.

Target Information

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

miR-135 protects against atrial fibrillation by suppressing intracellular calcium-mediated NLRP3 inflammasome activation.

Journal of cell communication and signaling

Yu Y,Fan Z,Han Y,Sun X,Dong C,Liu G,Yin X,Liu L,Bai Y,Yang B

Fri Sep 01 00:00:00 UTC 2023

Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhang L,Yan J,Liu J,Meng C,Liu F,Xia C

Fri Jul 01 00:00:00 UTC 2022

The expression of nutrient chemosensing gate molecules in the ileum and colon is altered for goats fed on a high-grain diet.

Animal science journal = Nihon chikusan Gakkaiho

Tian C,Wu J,Jiao J,Zhou C,Tan Z

Thu Jul 07 00:00:00 UTC 2022

Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation.

American journal of physiology. Cell physiology

Ahmed ASI,Sheng MHC,Lau KW,Wilson SM,Wongworawat MD,Tang X,Ghahramanpouri M,Nehme A,Xu Y,Abdipour A,Zhang XB,Wasnik S,Baylink DJ

Sun May 01 00:00:00 UTC 2022

Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole.

BioMed research international

Pang W,Lu S,Zheng R,Li X,Yang S,Feng Y,Wang S,Guo J,Zhou S

Tue Sep 13 00:00:00 UTC 2022

Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice.

Pediatric research

Mayer CA,Roos B,Teske J,Wells N,Martin RJ,Chang W,Pabelick CM,Prakash YS,MacFarlane PM

Sun May 01 00:00:00 UTC 2022

Renal tubular injury induced by glyphosate combined with hard water: the role of cytosolic phospholipase A2.

Annals of translational medicine

Wang R,Chen J,Ding F,Zhang L,Wu X,Wan Y,Hu J,Zhang X,Wu Q

Fri Jan 01 00:00:00 UTC 2021

Renal tubular injury induced by glyphosate combined with hard water: the role of cytosolic phospholipase A2.

Annals of translational medicine

Wang R,Chen J,Ding F,Zhang L,Wu X,Wan Y,Hu J,Zhang X,Wu Q

Fri Jan 01 00:00:00 UTC 2021

Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway.

Frontiers in pharmacology

Chen P,Wen Z,Shi W,Li Z,Chen X,Gao Y,Xu S,Gong Q,Deng J

Tue Oct 26 00:00:00 UTC 2021

Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats.

Journal of ethnopharmacology

Chen B,Wei J,Zhu R,Zhang H,Xia B,Liu Y,Dai X,Ye Z,Tian Y,Li R,Zhao D,Mo F,Orekhov AN,Gao S,Brὃmme D,Wang L,Zhang D

Thu Oct 28 00:00:00 UTC 2021

Ginsenoside Rg1 attenuates mechanical stress-induced cardiac injury via calcium sensing receptor-related pathway.

Journal of ginseng research

Lu ML,Wang J,Sun Y,Li C,Sun TR,Hou XW,Wang HX

Mon Nov 01 00:00:00 UTC 2021

Ginsenoside Rg1 attenuates mechanical stress-induced cardiac injury via calcium sensing receptor-related pathway.

Journal of ginseng research

Lu ML,Wang J,Sun Y,Li C,Sun TR,Hou XW,Wang HX

Mon Nov 01 00:00:00 UTC 2021

Ginsenoside Rg1 attenuates mechanical stress-induced cardiac injury via calcium sensing receptor-related pathway.

Journal of ginseng research

Lu ML,Wang J,Sun Y,Li C,Sun TR,Hou XW,Wang HX

Mon Nov 01 00:00:00 UTC 2021

Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1.

International journal of endocrinology

Hu X,Li M,Zhang C,Pang S

Wed Apr 20 00:00:00 UTC 2022

Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.

Acta pharmacologica Sinica

Yin B,Hou XW,Lu ML

Wed May 01 00:00:00 UTC 2019

Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.

Acta pharmacologica Sinica

Yin B,Hou XW,Lu ML

Wed May 01 00:00:00 UTC 2019

Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.

Acta pharmacologica Sinica

Yin B,Hou XW,Lu ML

Wed May 01 00:00:00 UTC 2019

Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.

Acta pharmacologica Sinica

Yin B,Hou XW,Lu ML

Wed May 01 00:00:00 UTC 2019

miR-429 and miR-424-5p inhibit cell proliferation and Ca²⁺ influx by downregulating CaSR in pulmonary artery smooth muscle cells.

American journal of physiology. Cell physiology

Li C,Qin F,Xue M,Lei Y,Hu F,Xu H,Sun G,Wang T,Guo M

Tue Jan 01 00:00:00 UTC 2019

miR-429 and miR-424-5p inhibit cell proliferation and Ca²⁺ influx by downregulating CaSR in pulmonary artery smooth muscle cells.

American journal of physiology. Cell physiology

Li C,Qin F,Xue M,Lei Y,Hu F,Xu H,Sun G,Wang T,Guo M

Tue Jan 01 00:00:00 UTC 2019

Calhex₂₃₁ Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro.

Biological & pharmaceutical bulletin

Yuan H,Xu J,Xu X,Gao T,Wang Y,Fan Y,Hu J,Shao Y,Zhao B,Li H,Sun J,Xu C

Thu Aug 01 00:00:00 UTC 2019

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.

Frontiers in pharmacology

Lu M,Leng B,He X,Zhang Z,Wang H,Tang F

Thu Oct 01 00:00:00 UTC 2020

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.

Frontiers in pharmacology

Lu M,Leng B,He X,Zhang Z,Wang H,Tang F

Thu Oct 01 00:00:00 UTC 2020

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.

Frontiers in pharmacology

Lu M,Leng B,He X,Zhang Z,Wang H,Tang F

Thu Oct 01 00:00:00 UTC 2020

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.

Frontiers in pharmacology

Lu M,Leng B,He X,Zhang Z,Wang H,Tang F

Thu Oct 01 00:00:00 UTC 2020

Role of autophagy in cadmium-induced testicular injury.

Human & experimental toxicology

Wang YJ,Yan J,Yin F,Li L,Qin YG,Meng CY,Lu RF,Guo L

Sun Oct 01 00:00:00 UTC 2017

Role of autophagy in cadmium-induced testicular injury.

Human & experimental toxicology

Wang YJ,Yan J,Yin F,Li L,Qin YG,Meng CY,Lu RF,Guo L

Sun Oct 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Ca sensing receptor; calcium-sensing receptor; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); CaR; CaSR; CaSR antibody; cation sensing receptor; Extracellular calcium-sensing receptor; G protein coupled receptor, family C, group 2, member A; G protein-coupled receptor, family C, group 2, member A; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; Parathyroid cell calcium-sensing receptor 1; PCaR1

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Gene Aliases: CAR; CASR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1

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UniProt ID: (Human) P41180, (Rat) P48442, (Mouse) Q9QY96

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Entrez Gene ID: (Human) 846, (Rat) 24247, (Mouse) 12374

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Function(s)

phosphatidylinositol phospholipase C activity G-protein coupled receptor activity protein binding magnesium ion binding integrin binding calcium ion binding drug binding polyamine binding protein kinase binding ion channel binding signal transducer activity

Process(es)

ossification detection of calcium ion cellular calcium ion homeostasis G-protein coupled receptor signaling pathway chemosensory behavior anatomical structure morphogenesis calcium ion import response to ischemia calcium ion transport apoptotic process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway JNK cascade positive regulation of cell proliferation response to metal ion positive regulation of gene expression response to organic cyclic compound positive regulation of insulin secretion positive regulation of ATPase activity cellular response to hepatocyte growth factor stimulus vasodilation positive regulation of vasoconstriction branching morphogenesis of an epithelial tube positive regulation of positive chemotaxis response to calcium ion regulation of calcium ion transport fat pad development cellular response to vitamin D cellular response to glucose stimulus cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia response to fibroblast growth factor positive regulation of calcium ion import cellular response to peptide signal transduction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Calcium Sensing Receptor Polyclonal Antibody

Calcium Sensing Receptor Antibody (19125-1-AP) in ICC/IF

Product Details

19125-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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