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Alomone Labs, LTD
Calcium Sensing Receptor (extracellular) Polyclonal Antibody, FITC
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Calcium Sensing Receptor (extracellular) Antibody (ACR-004-F-50UL) in Flow
Cell surface detection of CaSR in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG isotype control-FITC. (green) Cells + Anti-Calcium Sensing Receptor (extracellular)-FITC Antibody (#ACR-004-F), 2.5 µg.
Product Details
ACR-004-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)DDYGRPGIEKFREE, corresponding to amino acid residues 216-229 of human CaSR, Extracellular, N-terminus
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca sensing receptor; calcium-sensing receptor; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); CaR; CaSR; CaSR antibody; cation sensing receptor; Extracellular calcium-sensing receptor; G protein coupled receptor, family C, group 2, member A; G protein-coupled receptor, family C, group 2, member A; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; Parathyroid cell calcium-sensing receptor 1; PCaR1
Gene Aliases: CAR; CASR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1
UniProt ID: (Human) P41180, (Rat) P48442, (Mouse) Q9QY96
Entrez Gene ID: (Human) 846, (Rat) 24247, (Mouse) 12374
ossification
detection of calcium ion
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
chemosensory behavior
anatomical structure morphogenesis
calcium ion import
response to ischemia
calcium ion transport
apoptotic process
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
JNK cascade
positive regulation of cell proliferation
response to metal ion
positive regulation of gene expression
response to organic cyclic compound
positive regulation of insulin secretion
positive regulation of ATPase activity
cellular response to hepatocyte growth factor stimulus
vasodilation
positive regulation of vasoconstriction
branching morphogenesis of an epithelial tube
positive regulation of positive chemotaxis
response to calcium ion
regulation of calcium ion transport
fat pad development
cellular response to vitamin D
cellular response to glucose stimulus
cellular response to low-density lipoprotein particle stimulus
cellular response to hypoxia
response to fibroblast growth factor
positive regulation of calcium ion import
cellular response to peptide
signal transduction
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