Invitrogen

Calmodulin 2 Polyclonal Antibody

View all (4) Calmodulin 2 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-121166

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.08 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914738

Product Specific Information

Positive test controls include: NIH/3T3, MCF7, BT-474, NCI-H460, Mouse brain. The target is usually found in the following locations: Cytoplasm, cytoskeleton, spindle, spindle pole.

Immunogen sequence: MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK

Target Information

Calmodulin 2 (CALM2) is one of the three human genes encoding calmodulin, a highly conserved calcium-binding messenger protein critical for mediating various cellular processes. Calmodulin proteins are composed of two pairs of EF-hand motifs located at both the N- and C-termini, connected by a flexible central linker. Each EF-hand motif binds calcium ions, with the C-terminus possessing two high-affinity Ca2+ binding sites, while the N-terminus contains two low-affinity sites. Upon binding calcium, calmodulin undergoes a conformational change that enables it to interact with and regulate numerous target proteins, including kinases, phosphatases, ion channels, and other enzymes. Specifically, calcium/calmodulin (CaM) signaling pathways are involved in critical cellular functions such as muscle contraction, neurotransmitter release, and cellular growth. The interaction of CALM2 with different targets is essential for translating transient changes in intracellular calcium levels into specific cellular responses, making it a pivotal player in calcium signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: calmodulin; calmodulin 2 (phosphorylase kinase, delta); Calmodulin-1; Calmodulin-2; Calmodulin-3; caM; LP7057 protein; phosphorylase kinase delta; phosphorylase kinase subunit delta; prepro-calmodulin 2

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Gene Aliases: 1500001E21Rik; AL024017; CALM; CALM1; CALM2; CALM3; CALML2; CAM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMII; CAMIII; LQT15; PHKD; PHKD2

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UniProt ID: (Human) P0DP25, (Mouse) P0DP28

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Entrez Gene ID: (Human) 805, (Mouse) 12314

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Function(s)
Ras guanyl-nucleotide exchange factor activity calcium ion binding protein binding adenylate cyclase binding inositol-1,4,5-trisphosphate 3-kinase activity ligand-gated ion channel activity protein kinase binding protein domain specific binding nitric-oxide synthase regulator activity titin binding type 3 metabotropic glutamate receptor binding thioesterase binding N-terminal myristoylation domain binding phospholipase binding protein serine/threonine kinase activator activity phosphatidylinositol 3-kinase binding ion channel binding calcium-dependent protein binding nitric-oxide synthase binding protein phosphatase activator activity enzyme regulator activity protein N-terminus binding
Process(es)
G2/M transition of mitotic cell cycle regulation of catalytic activity MAPK cascade response to amphetamine regulation of heart rate platelet degranulation detection of calcium ion glycogen catabolic process muscle contraction G-protein coupled receptor signaling pathway activation of adenylate cyclase activity Wnt signaling pathway, calcium modulating pathway positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion substantia nigra development regulation of rhodopsin mediated signaling pathway positive regulation of cyclic nucleotide metabolic process positive regulation of protein autophosphorylation regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity ion transmembrane transport positive regulation of protein dephosphorylation Fc-epsilon receptor signaling pathway positive regulation of DNA binding positive regulation of GTPase activity inositol phosphate metabolic process regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase activity positive regulation of cyclic-nucleotide phosphodiesterase activity response to corticosterone response to calcium ion regulation of cardiac muscle contraction negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of protein serine/threonine kinase activity regulation of high voltage-gated calcium channel activity regulation of cell communication by electrical coupling involved in cardiac conduction
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