Invitrogen

Calmodulin 2 Polyclonal Antibody

View all (4) Calmodulin 2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-27515

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human Calmodulin 2. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544991

Product Specific Information

Recommended positive controls: Mouse brain.

Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%), Rabbit (100%), Sheep (100%), Chimpanzee (100%), Bovine (100%), Guinea pig (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Calmodulin 2 (CALM2) is one of the three human genes encoding calmodulin, a highly conserved calcium-binding messenger protein critical for mediating various cellular processes. Calmodulin proteins are composed of two pairs of EF-hand motifs located at both the N- and C-termini, connected by a flexible central linker. Each EF-hand motif binds calcium ions, with the C-terminus possessing two high-affinity Ca2+ binding sites, while the N-terminus contains two low-affinity sites. Upon binding calcium, calmodulin undergoes a conformational change that enables it to interact with and regulate numerous target proteins, including kinases, phosphatases, ion channels, and other enzymes. Specifically, calcium/calmodulin (CaM) signaling pathways are involved in critical cellular functions such as muscle contraction, neurotransmitter release, and cellular growth. The interaction of CALM2 with different targets is essential for translating transient changes in intracellular calcium levels into specific cellular responses, making it a pivotal player in calcium signaling.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: calmodulin; calmodulin 2 (phosphorylase kinase, delta); Calmodulin-1; Calmodulin-2; Calmodulin-3; caM; LP7057 protein; phosphorylase kinase delta; phosphorylase kinase subunit delta; prepro-calmodulin 2

View more View less

Gene Aliases: 1500001E21Rik; AL024017; CALM; CALM1; CALM2; CALM3; CALML2; CAM; CAM1; CAM2; CAM3; CAMB; CAMC; CaMI; CAMII; CAMIII; LQT15; PHKD; PHKD2

View more View less

UniProt ID: (Human) P0DP25, (Rat) P0DP30, (Mouse) P0DP28

View more View less

Entrez Gene ID: (Human) 805, (Rat) 50663, (Mouse) 12314

View more View less

Function(s)
Ras guanyl-nucleotide exchange factor activity calcium ion binding protein binding adenylate cyclase binding inositol-1,4,5-trisphosphate 3-kinase activity ligand-gated ion channel activity protein kinase binding protein domain specific binding nitric-oxide synthase regulator activity titin binding type 3 metabotropic glutamate receptor binding thioesterase binding N-terminal myristoylation domain binding phospholipase binding protein serine/threonine kinase activator activity phosphatidylinositol 3-kinase binding ion channel binding calcium-dependent protein binding nitric-oxide synthase binding protein phosphatase activator activity enzyme regulator activity protein N-terminus binding
Process(es)
G2/M transition of mitotic cell cycle regulation of catalytic activity MAPK cascade response to amphetamine regulation of heart rate platelet degranulation detection of calcium ion glycogen catabolic process muscle contraction G-protein coupled receptor signaling pathway activation of adenylate cyclase activity Wnt signaling pathway, calcium modulating pathway positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion substantia nigra development regulation of rhodopsin mediated signaling pathway positive regulation of cyclic nucleotide metabolic process positive regulation of protein autophosphorylation regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity ion transmembrane transport positive regulation of protein dephosphorylation Fc-epsilon receptor signaling pathway positive regulation of DNA binding positive regulation of GTPase activity inositol phosphate metabolic process regulation of nitric-oxide synthase activity positive regulation of nitric-oxide synthase activity positive regulation of cyclic-nucleotide phosphodiesterase activity response to corticosterone response to calcium ion regulation of cardiac muscle contraction negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of protein serine/threonine kinase activity regulation of high voltage-gated calcium channel activity regulation of cell communication by electrical coupling involved in cardiac conduction
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support