Invitrogen

Calmodulin 3 Polyclonal Antibody

View all (7) Calmodulin 3 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-29980

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human Calmodulin 3. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.48 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2547454

Product Specific Information

Recommended positive controls: Mouse brain.

Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Bovine (100%), Guinea pig (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: calmodulin; calmodulin 3 (phosphorylase kinase, delta); Calmodulin III; Calmodulin-1; Calmodulin-2; Calmodulin-3; caM; epididymis secretory protein Li 72; phosphorylase kinase subunit delta; prepro-calmodulin 3

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Gene Aliases: CALM; CALM1; CALM2; CALM3; CALML2; CAM; CAM1; CAM2; CAM3; CaMA; CAMB; CAMC; CaMI; CaMII; CAMIII; HEL-S-72; PHKD; PHKD3; R75142; RNCAMIII

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UniProt ID: (Human) P0DP25, (Rat) P0DP30, (Mouse) P0DP28

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Entrez Gene ID: (Human) 808, (Rat) 24244, (Mouse) 12315

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Function(s)
Ras guanyl-nucleotide exchange factor activity calcium ion binding protein binding adenylate cyclase binding inositol-1,4,5-trisphosphate 3-kinase activity ligand-gated ion channel activity protein kinase binding protein domain specific binding nitric-oxide synthase regulator activity titin binding type 3 metabotropic glutamate receptor binding thioesterase binding N-terminal myristoylation domain binding phospholipase binding protein serine/threonine kinase activator activity phosphatidylinositol 3-kinase binding ion channel binding calcium-dependent protein binding nitric-oxide synthase binding protein phosphatase activator activity enzyme regulator activity protein N-terminus binding
Process(es)
G2/M transition of mitotic cell cycle response to amphetamine regulation of heart rate detection of calcium ion activation of adenylate cyclase activity regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium-mediated signaling substantia nigra development regulation of cytokinesis positive regulation of phosphoprotein phosphatase activity positive regulation of protein dephosphorylation positive regulation of nitric-oxide synthase activity positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity regulation of store-operated calcium channel activity regulation of high voltage-gated calcium channel activity MAPK cascade platelet degranulation glycogen catabolic process muscle contraction G-protein coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of rhodopsin mediated signaling pathway positive regulation of cyclic nucleotide metabolic process positive regulation of protein autophosphorylation ion transmembrane transport Fc-epsilon receptor signaling pathway positive regulation of DNA binding positive regulation of GTPase activity inositol phosphate metabolic process regulation of nitric-oxide synthase activity response to corticosterone response to calcium ion negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of protein serine/threonine kinase activity regulation of cell communication by electrical coupling involved in cardiac conduction regulation of catalytic activity
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