Invitrogen

Calmyrin Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-27284

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human CIB1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544760

Product Specific Information

Recommended positive controls: A431.

Predicted reactivity: Mouse (97%), Rat (98%), Zebrafish (80%), Sheep (97%), Bovine (97%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alphabeta, which may implicate this protein as a regulatory molecule for alphabeta.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: calcium and integrin binding 1 (calmyrin); Calcium and integrin-binding protein 1; Calcium- and integrin-binding protein; Calmyrin; CIB; CIBP; DNA-dependent protein kinase interacting protein; DNA-PK interaction protein; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; SIP2-28; SNK-interacting protein 2-28; testicular secretory protein Li 9

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Gene Aliases: CIB; CIB1; CIBP; KIP; KIP1; PRKDCIP; SIP2-28

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UniProt ID: (Human) Q99828

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Entrez Gene ID: (Human) 10519

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Function(s)
calcium ion binding protein binding protein C-terminus binding calcium-dependent protein kinase inhibitor activity Ras GTPase binding protein kinase binding protein serine/threonine kinase inhibitor activity protein anchor ion channel binding
Process(es)
angiogenesis negative regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of cell-matrix adhesion response to ischemia double-strand break repair apoptotic process cellular response to DNA damage stimulus negative regulation of microtubule depolymerization endomitotic cell cycle cell adhesion spermatid development positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of neuron projection development platelet formation positive regulation of cell growth positive regulation of cell migration cytoplasmic microtubule organization positive regulation of cell adhesion mediated by integrin thrombopoietin-mediated signaling pathway regulation of cell proliferation negative regulation of apoptotic process positive regulation of catalytic activity negative regulation of megakaryocyte differentiation positive regulation of NF-kappaB transcription factor activity cell division regulation of cell division negative regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade positive regulation of calcineurin-NFAT signaling cascade cellular response to tumor necrosis factor cellular response to growth factor stimulus negative regulation of protein serine/threonine kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of establishment of protein localization to plasma membrane positive regulation of cell migration involved in sprouting angiogenesis positive regulation of protein targeting to membrane extrinsic apoptotic signaling pathway positive regulation of substrate adhesion-dependent cell spreading cellular response to nerve growth factor stimulus positive regulation of male germ cell proliferation
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