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NeoBiotechnologies
Calnexin (Endoplasmic Reticulum Marker) Recombinant Rabbit Monoclonal Antibody (CANX/9147R)
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Product Details
821-RBM6-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
CANX/9147R
Immunogen
Recombinant N-terminal fragment of human Calnexin protein (around aa 1-300).
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: HeLa MCF-7 or U2OS cells. Kidney or small intestine.
Cellular Location: Cytoplasm.
Target Information
Calnexin, also referred to as IP90, p88 and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatibility complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase. Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention. Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calnexin; FLJ26570; IP90; Major histocompatibility complex class I antigen-binding protein p88; p88; p90
Gene Aliases: CANX; CNX; IP90; P90
UniProt ID: (Human) P27824
Entrez Gene ID: (Human) 821
antigen processing and presentation of peptide antigen via MHC class I
protein folding
aging
protein secretion
antigen processing and presentation of exogenous peptide antigen via MHC class II
protein folding in endoplasmic reticulum
synaptic vesicle endocytosis
chaperone-mediated protein folding
clathrin-mediated endocytosis
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