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Proteintech
Calpain 7 Polyclonal Antibody
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Product Details
13870-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Calpain 7 Fusion Protein Ag4820 (235-533 aa encoded by BC056202)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FAYPMPFCD RWGKLPLSPK QKTTFSKWVR PEDLTNNPTM IYTVSSFSIK QTIVSDCSFV ASLAISAAYE RRFNKKLITG IIYPQNKDGE PEYNPCGKYM VKLHLNGVPR KVIIDDQLPV DHKGELLCSY SNNKSELWVS LIEKAYMKVM GGYDFPGSNS NIDLHALTGW IPERIAMHSD SQTFSKDNSF RMLYQRFHKG DVLITASTGM MTEAEGEKWG LVPTHAYAVL DIREFKGLRF IQLKNPWSHL RWKGRYSEND VENWTPELQK YLNFDPRTAQ KIDNGIFWIS WDDLCQYYDV (235-533 aa encoded by BC056202)
Target Information
Calpain proteinases are defined currently as papain-like neutral proteases that are calcium activated. Calpains 1 and 2 are composed of a large subunit, which is proteolytically active, and a small subunit (also called calpain-4), or enhancer protein, that is not proteolytically active. The other calpain proteins identified to date (calpain 5, 6, 8, 9, 10, 11, 12, 13, 14, 15) are not known to require a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain-T in calpains 5 & 6, domain-N for calpain-7). Calpain-7 domain-N does not have the standard calpain EF hand domain for binding calcium, making it unclear whether it is calcium regulated. In place of the EF hand calcium-binding domain IV, calpain-7 has a sequence most closely resembling domain-III, with unknown function. Calpain-7 is widely distributed, found in most tissues analyzed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calpain like protease; Calpain-7; homolog of Aspergillus Nidulans PALB; PalB homolog; PalBH
Gene Aliases: AU022319; CALPAIN7; CAPN7; PALBH
UniProt ID: (Human) Q9Y6W3, (Mouse) Q9R1S8
Entrez Gene ID: (Human) 23473, (Rat) 306260, (Mouse) 12339
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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