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Invitrogen
Calpain 7 Polyclonal Antibody
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Product Details
PA5-116762
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-220 of human CAPN7 (NP_0551111)
Conjugate
Form
Liquid
Concentration
2.36 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901393
Product Specific Information
Positive Samples: Jurkat
Immunogen sequence: RDHEGRYSEA VFYYKEAAQA LIYAEMAGSS LENIQEKITE YLERVQALHS AVQSKSADPL KSKHQLDLER AHFLVTQAFD EDEKENVEDA IELYTEAVDL CLKTSYETAD KVLQNKLKQL ARQALDRAEA LSEPLTKPVG KISSTSVKPK PPPVRAHFPL GANPFLERPQ SFISPQSCDA QGQRYTAEEI EVLRTTSKIN G
Target Information
Calpain proteinases are defined currently as papain-like neutral proteases that are calcium activated. Calpains 1 and 2 are composed of a large subunit, which is proteolytically active, and a small subunit (also called calpain-4), or enhancer protein, that is not proteolytically active. The other calpain proteins identified to date (calpain 5, 6, 8, 9, 10, 11, 12, 13, 14, 15) are not known to require a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain-T in calpains 5 & 6, domain-N for calpain-7). Calpain-7 domain-N does not have the standard calpain EF hand domain for binding calcium, making it unclear whether it is calcium regulated. In place of the EF hand calcium-binding domain IV, calpain-7 has a sequence most closely resembling domain-III, with unknown function. Calpain-7 is widely distributed, found in most tissues analyzed.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calpain like protease; Calpain-7; homolog of Aspergillus Nidulans PALB; PalB homolog; PalBH
Gene Aliases: AU022319; CALPAIN7; CAPN7; PALBH
UniProt ID: (Human) Q9Y6W3, (Mouse) Q9R1S8
Entrez Gene ID: (Human) 23473, (Rat) 306260, (Mouse) 12339
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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