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Immunogen sequence: ESEARTPFG LIKGHAYSVT GIDQVSFRGQ RIELIRIRNP WGQVEWNGSW SDSSPEWRSV GPAEQKRLCH TALDDGEFWM AFQDFKAHFD KVEICNLTPD ALEEDAIHKW EVTVHQGSWV RGSTAGGCRN FLDTFWTNPQ IKLSLTEKDE GQEECSFLVA LMQKDRRKLK RFGANVLTIG YAIYECPDKD EHLNKDFFRY HASRARSKTF INLREVSDRF KLPPGEYILI PSTFEPHQEA DFCLRIFSEK KAITRDMDGN VDIDLPEPPK PTPPDQETEE EQRFRALFEQ VAGEDMEVTA EELEYVLNAV LQKKKDIKFK KLSLISCKNI ISLMDTSGNG KLEFDEFKVF WDKLKQWINL FLRFDADKSG TMSTYELRTA LKAAGFQLSS HLLQLIVLRY ADEELQLDFD DFLNCLVRLE NASRVFQALS TKNKEFIHLN INEFIHLTMN I (178-627 aa encoded by BC027993)
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Calpain-9; Digestive tract-specific calpain; nCL-4; New calpain 4; novel calpain large subunit-4; Protein CG36
Gene Aliases: 2200003B16Rik; CAPN9; GC36; Ncl-4; NCL4
UniProt ID: (Human) O14815, (Mouse) Q9D805, (Rat) O35920
Entrez Gene ID: (Human) 10753, (Mouse) 73647, (Rat) 116694
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