Invitrogen

Calreticulin Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA1-16924

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent
-

Immunocytochemistry (ICC/IF)

1:20-1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Full length native mouse Calreticulin protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_779492

Product Specific Information

PA1-16924 is specific for the ~55 kDa Calreticulin protein.

There are also several reported isoforms that range from 48-62 kDa.

Suggested positive control: antigen standard for CALR (transient overexpression lysate).

Target Information

Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Autoantigen RO; Calregulin; Calreticulin; CRP55; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin)

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Gene Aliases: CALR; Calregulin; cC1qR; CRT; CRTC; HEL-S-99n; RO; SSA

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UniProt ID: (Human) P27797, (Mouse) P14211

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Entrez Gene ID: (Human) 811, (Mouse) 12317

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Function(s)
complement component C1q binding glycoprotein binding DNA binding mRNA binding integrin binding iron ion binding calcium ion binding protein binding zinc ion binding carbohydrate binding ubiquitin protein ligase binding peptide binding hormone binding protein binding involved in protein folding poly(A) RNA binding androgen receptor binding unfolded protein binding chaperone binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter peptide antigen assembly with MHC class I protein complex protein folding protein export from nucleus cell cycle arrest positive regulation of cell proliferation positive regulation of gene expression negative regulation of translation cortical actin cytoskeleton organization negative regulation of intracellular steroid hormone receptor signaling pathway protein localization to nucleus regulation of meiotic nuclear division negative regulation of neuron differentiation positive regulation of DNA replication positive regulation of cell cycle negative regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway positive regulation of phagocytosis protein stabilization chaperone-mediated protein folding cellular senescence positive regulation of substrate adhesion-dependent cell spreading positive regulation of dendritic cell chemotaxis antigen processing and presentation of peptide antigen via MHC class I regulation of transcription, DNA-templated cellular calcium ion homeostasis receptor-mediated endocytosis spermatogenesis protein maturation by protein folding response to estradiol response to testosterone protein folding in endoplasmic reticulum ATF6-mediated unfolded protein response response to drug glucocorticoid receptor signaling pathway regulation of apoptotic process sequestering of calcium ion cardiac muscle cell differentiation cellular response to lithium ion
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