Product References
RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.
Cellular oncology (Dordrecht, Netherlands)
Yao H,Zhang S,Xie H,Fan Y,Miao M,Zhu R,Yuan L,Gu M,You Y,You B
PA3-900 was used in Immunoprecipitation to demonstrate that calreticulin (CALR) resides primarily in the endoplasmic reticulum and interacts with RCN2.
Tue Aug 01 00:00:00 UTC 2023
Nanoparticles with ultrasound-induced afterglow luminescence for tumour-specific theranostics.
Nature biomedical engineering
Xu C,Huang J,Jiang Y,He S,Zhang C,Pu K
PA3-900 was used in Immunohistochemistry to report the development of organic nanoparticles producing ultrasound-induced afterglow, and their proof-of-concept application in cancer immunotheranostics.
Wed Mar 01 00:00:00 UTC 2023
Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum.
npj aging
Zarate SM,Huntington TE,Bagher P,Srinivasan R
PA3-900 was used in Immunohistochemistry-immunofluorescence to conclude that astrocytic endfeet show significant changes in calcium buffering and sources throughout the lifespan, which is important for understanding mechanisms by which aging impairs the BBB and NVU.
Fri Mar 31 00:00:00 UTC 2023
Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103.
Molecular cancer therapeutics
Bushey RT,Saxena R,Campa MJ,Gottlin EB,He YW,Patz EF
PA3-900 was used in Western Blotting and Immunocytochemistry to demonstrate that GT103 causes B-cell activation in vitro and in vivo, and that GT103 antitumor activity in vivo is B-cell dependent.
Thu Jun 01 00:00:00 UTC 2023
Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103.
Molecular cancer therapeutics
Bushey RT,Saxena R,Campa MJ,Gottlin EB,He YW,Patz EF
PA3-900 was used in Western Blotting and Immunocytochemistry to demonstrate that GT103 causes B-cell activation in vitro and in vivo, and that GT103 antitumor activity in vivo is B-cell dependent.
Thu Jun 01 00:00:00 UTC 2023
Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103.
Molecular cancer therapeutics
Bushey RT,Saxena R,Campa MJ,Gottlin EB,He YW,Patz EF
PA3-900 was used in Western Blotting and Immunocytochemistry to demonstrate that GT103 causes B-cell activation in vitro and in vivo, and that GT103 antitumor activity in vivo is B-cell dependent.
Thu Jun 01 00:00:00 UTC 2023
Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103.
Molecular cancer therapeutics
Bushey RT,Saxena R,Campa MJ,Gottlin EB,He YW,Patz EF
PA3-900 was used in Western Blotting and Immunocytochemistry to demonstrate that GT103 causes B-cell activation in vitro and in vivo, and that GT103 antitumor activity in vivo is B-cell dependent.
Thu Jun 01 00:00:00 UTC 2023
Endoplasmic reticulum stress-induced release and binding of calreticulin from human ovarian cancer cells.
Cancer immunology, immunotherapy : CII
Abdullah TM,Whatmore J,Bremer E,Slibinskas R,Michalak M,Eggleton P
PA3-900 was used in ELISA to investigate at what stage of cell viability, calreticulin appeared associated with the surface of human ovarian cancer cells.
Fri Jul 01 00:00:00 UTC 2022
Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma.
Experimental hematology & oncology
Haney SL,Varney ML,Williams JT,Smith LM,Talmon G,Holstein SA
PA3-900 was used in Flow Cytometry to demonstrate that GGSI/PI treatment can potentiate activation of the UPR and apoptotic pathway, as well as induce upregulation of markers associated with the ICD pathway.
Wed Feb 09 00:00:00 UTC 2022
Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells.
Biomedicines
Lin YC,Huang YL,Wang MH,Chen CY,Chen WM,Weng YC,Wu PY
PA3-900 was used in Western Blot to determine the effects of calreticulin on β1-integrin in human prostate cancer PC-3 cells.
Fri Mar 11 00:00:00 UTC 2022
Schweinfurthin induces ICD without ER stress and caspase activation.
Oncoimmunology
Zhang R,Neighbors JD,Schell TD,Hohl RJ
PA3-900 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which MeSG treatment induces immunogenic cell death (ICD).
Tue Aug 09 00:00:00 UTC 2022
Axonal Length Determines Distinct Homeostatic Phenotypes in Human iPSC Derived Motor Neurons on a Bioengineered Platform.
Advanced healthcare materials
Hagemann C,Moreno Gonzalez C,Guetta L,Tyzack G,Chiappini C,Legati A,Patani R,Serio A
PA3-900 was used in Immunocytochemistry-immunofluorescence to demonstrate the existence of a length-dependent mechanism that switches homeostatic processes within human MNs.
Sun May 01 00:00:00 UTC 2022
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Neuron
Kuijpers M,Kochlamazashvili G,Stumpf A,Puchkov D,Swaminathan A,Lucht MT,Krause E,Maritzen T,Schmitz D,Haucke V
PA3-900 was used in Western Blot, Immunohistochemistry to demonstrate that loss of neuronal autophagy causes selective accumulation of tubular endoplasmic reticulum (ER) in axons, resulting in increased excitatory neurotransmission and compromised postnatal viability in vivo.
Wed Jan 20 00:00:00 UTC 2021
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Neuron
Kuijpers M,Kochlamazashvili G,Stumpf A,Puchkov D,Swaminathan A,Lucht MT,Krause E,Maritzen T,Schmitz D,Haucke V
PA3-900 was used in Western Blot, Immunohistochemistry to demonstrate that loss of neuronal autophagy causes selective accumulation of tubular endoplasmic reticulum (ER) in axons, resulting in increased excitatory neurotransmission and compromised postnatal viability in vivo.
Wed Jan 20 00:00:00 UTC 2021
Local translation in nuclear condensate amyloid bodies.
Proceedings of the National Academy of Sciences of the United States of America
Theodoridis PR,Bokros M,Marijan D,Balukoff NC,Wang D,Kirk CC,Budine TD,Goldsmith HD,Wang M,Audas TE,Lee S
PA3-900 was used in Immunocytochemistry, Western Blot to show that solid-like amyloid bodies coordinate local nuclear protein synthesis during stress.
Tue Feb 16 00:00:00 UTC 2021
Local translation in nuclear condensate amyloid bodies.
Proceedings of the National Academy of Sciences of the United States of America
Theodoridis PR,Bokros M,Marijan D,Balukoff NC,Wang D,Kirk CC,Budine TD,Goldsmith HD,Wang M,Audas TE,Lee S
PA3-900 was used in Immunocytochemistry, Western Blot to show that solid-like amyloid bodies coordinate local nuclear protein synthesis during stress.
Tue Feb 16 00:00:00 UTC 2021
Mechanism of mutant calreticulin-mediated activation of the thrombopoietin receptor in cancers.
The Journal of cell biology
Venkatesan A,Geng J,Kandarpa M,Wijeyesakere SJ,Bhide A,Talpaz M,Pogozheva ID,Raghavan M
PA3-900 was used in Immunoprecipitation, Western Blot to show that MPNs exploit a natural dimerization interface of CRT combined with C-domain gain of function to achieve cell transformation.
Mon Jul 05 00:00:00 UTC 2021
Mechanism of mutant calreticulin-mediated activation of the thrombopoietin receptor in cancers.
The Journal of cell biology
Venkatesan A,Geng J,Kandarpa M,Wijeyesakere SJ,Bhide A,Talpaz M,Pogozheva ID,Raghavan M
PA3-900 was used in Immunoprecipitation, Western Blot to show that MPNs exploit a natural dimerization interface of CRT combined with C-domain gain of function to achieve cell transformation.
Mon Jul 05 00:00:00 UTC 2021
CREB3L2 Modulates Nerve Growth Factor-Induced Cell Differentiation.
Frontiers in molecular neuroscience
Sampieri L,Funes Chabán M,Di Giusto P,Rozés-Salvador V,Alvarez C
PA3-900 was used in Immunocytochemistry to analyze the expression and signaling mechanism of CREB3 transcription factor family members, using the NGF-induced PC12 cell differentiation model.
Tue Aug 24 00:00:00 UTC 2021
Bio-nanoparticle based therapeutic vaccine induces immunogenic response against triple negative breast cancer.
American journal of cancer research
Bai X,Zhou Y,Lin Q,Huang CK,Zhang S,Carlson RI,Ghanbari H,Sun B,Wands JR,Dong X
PA3-900 was used in Western Blotting to conclude that λ phage vaccine targeting a TAA (ASPH) combined with DOX successfully induces ICD and initiates CD8+ T cell-mediated antitumor immunity in breast tumors.
Tue May 07 00:00:00 UTC 2024
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders.
EMBO molecular medicine
Pavlou M,Schön C,Occelli LM,Rossi A,Meumann N,Boyd RF,Bartoe JT,Siedlecki J,Gerhardt MJ,Babutzka S,Bogedein J,Wagner JE,Priglinger SG,Biel M,Petersen-Jones SM,Büning H,Michalakis S
PA3-900 was used in Western Blotting to report the development of novel engineered rAAV vectors that enable efficient targeting of photoreceptors via less invasive intravitreal administration.
Fri Apr 09 00:00:00 UTC 2021
Quantification of organelle contact sites by split-GFP-based contact site sensors (SPLICS) in living cells.
Nature protocols
Calì T,Brini M
PA3-900 was used in Immunocytochemistry to describe the use of split-GFP-based contact site sensors (SPLICS) in microscopy applications for mapping organelle contact sites both in fixed and living cells.
Mon Nov 01 00:00:00 UTC 2021
Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade.
Cell chemical biology
Hatstat AK,Ahrendt HD,Foster MW,Mayne L,Moseley MA,Englander SW,McCafferty DG
PA3-900 was used in Immunocytochemistry-immunofluorescence to investigate the effect of NAB2 on Nedd4 activity and specificity.
Thu Jan 21 00:00:00 UTC 2021
An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.
eLife
Coukos R,Yao D,Sanchez MI,Strand ET,Olive ME,Udeshi ND,Weissman JS,Carr SA,Bassik MC,Ting AY
PA3-900 was used in Western Blotting to demonstrate a distinct regulatory role for EMC10 in the ER membrane complex, opposing the transmembrane-domain insertion activity of the complex.
Fri Aug 20 00:00:00 UTC 2021
A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells.
Cancers
Tukaramrao DB,Malla S,Saraiya S,Hanely RA,Ray A,Kumari S,Raman D,Tiwari AK
PA3-900 was used in Immunocytochemistry to report a novel chemotherapeutic compound - TPH104 - capable of inducing immunogenic cell death in a triple-negative breast cancer (TNBC) cell line.
Sun Apr 18 00:00:00 UTC 2021
Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors.
ACS nano
Mei KC,Liao YP,Jiang J,Chiang M,Khazaieli M,Liu X,Wang X,Liu Q,Chang CH,Zhang X,Li J,Ji Y,Melano B,Telesca D,Xia T,Meng H,Nel AE
PA3-900 was used in Flow Cytometry to support the use of encapsulated MTO delivery for chemo-immunotherapy, with the possibility to boost the immune response by codelivery of an IDO-1 pathway inhibitor.
Tue Oct 27 00:00:00 UTC 2020
Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models.
International journal of radiation oncology, biology, physics
Seyedin SN,Hasibuzzaman MM,Pham V,Petronek MS,Callaghan C,Kalen AL,Mapuskar KA,Mott SL,Spitz DR,Allen BG,Caster JM
PA3-900 was used in Flow Cytometry to provide preclinical evidence for a novel therapeutic strategy to enhance responsiveness of colorectal tumors to immune checkpoint inhibitors.
Tue Sep 01 00:00:00 UTC 2020
Past and ongoing adaptation of human cytomegalovirus to its host.
PLoS pathogens
Mozzi A,Biolatti M,Cagliani R,Forni D,Dell'Oste V,Pontremoli C,Vantaggiato C,Pozzoli U,Clerici M,Landolfo S,Sironi M
PA3-900 was used in Immunocytochemistry-immunoflourescence to use evolutionary information to generate experimentally-testable hypotheses on the functional effect of HCMV genetic diversity and we define modulators of viral phenotypes.
Fri May 01 00:00:00 UTC 2020
Endothelial calreticulin deletion impairs endothelial function in aged mice.
American journal of physiology. Heart and circulatory physiology
Biwer LA,Askew-Page HR,Hong K,Milstein J,Johnstone SR,Macal E,Good ME,Bagher P,Sonkusare SK,Isakson BE
PA3-900 was used in Western Blot to rescue the effect of Calr deletion on endothelial-dependent vasodilatory function using tauroursodeoxycholic acid (TUDCA), an inhibitor of endoplasmic reticulum stress that is currently in clinical trials.
Fri May 01 00:00:00 UTC 2020
Calsequestrins New Calcium Store Markers of Adult Zebrafish Cerebellum and Optic Tectum.
Frontiers in neuroanatomy
Furlan S,Campione M,Murgia M,Mosole S,Argenton F,Volpe P,Nori A
PA3-900 was used in Immunohistochemistry to identify new endoplasmic reticulum (ER) calcium store markers in zebrafish adult brain with emphasis on cerebellum and optic tectum.
Mon Sep 28 00:00:00 UTC 2020
Immunomodulatory activity of IR700-labelled affibody targeting HER2.
Cell death & disease
Mączyńska J,Da Pieve C,Burley TA,Raes F,Shah A,Saczko J,Harrington KJ,Kramer-Marek G
PA3-900 was used in Flow cytometry/Cell sorting to investigate the feasibility of a novel HER2-targeted affibody-based conjugate (ZHER2:2395-IR700) selectively to induce cancer cell death in vitro and in vivo.
Tue Oct 20 00:00:00 UTC 2020
Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain.
Life science alliance
Benfield CT,MacKenzie F,Ritzefeld M,Mazzon M,Weston S,Tate EW,Teo BH,Smith SE,Kellam P,Holmes EC,Marsh M
PA3-900 was used in Western Blotting to highlight S-palmitoylation to be critical for Chiropteran IFITM3 function.
Wed Jan 01 00:00:00 UTC 2020
Rafoxanide Induces Immunogenic Death of Colorectal Cancer Cells.
Cancers
Di Grazia A,Laudisi F,Di Fusco D,Franzè E,Ortenzi A,Monteleone I,Monteleone G,Stolfi C
PA3-900 was used in Flow cytometry/Cell sorting to investigate whether rafoxanide could promote ICD of CRC cells.
Thu May 21 00:00:00 UTC 2020
Detailed analyses of the crucial functions of Zn transporter proteins in alkaline phosphatase activation.
The Journal of biological chemistry
Suzuki E,Ogawa N,Takeda TA,Nishito Y,Tanaka YK,Fujiwara T,Matsunaga M,Ueda S,Kubo N,Tsuji T,Fukunaka A,Yamazaki T,Taylor KM,Ogra Y,Kambe T
PA3-900 was used in Western Blotting to develop understanding of the molecular mechanisms underlying zinc ectoenzyme activation in the compartments of the early secretory pathway.
Fri Apr 24 00:00:00 UTC 2020
Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer.
Cell death & disease
Ma J,Ramachandran M,Jin C,Quijano-Rubio C,Martikainen M,Yu D,Essand M
PA3-900 was used in Flow cytometry/Cell sorting to characterize the ICD-inducing ability of wild-type Adenovirus (Ad), Semliki Forest virus (SFV) and Vaccinia virus (VV) by investigating the cell death, and immune-activating properties of virus-killed tumor cells.
Wed Jan 22 00:00:00 UTC 2020
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death.
Cells
Kopecka J,Godel M,Dei S,Giampietro R,Belisario DC,Akman M,Contino M,Teodori E,Riganti C
PA3-900 was used in Western Blotting to determine whether P-glycoprotein (Pgp) inhibitors can restore immunogenic cell death (ICD).
Wed Apr 22 00:00:00 UTC 2020
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death.
Cells
Kopecka J,Godel M,Dei S,Giampietro R,Belisario DC,Akman M,Contino M,Teodori E,Riganti C
PA3-900 was used in Western Blotting to determine whether P-glycoprotein (Pgp) inhibitors can restore immunogenic cell death (ICD).
Wed Apr 22 00:00:00 UTC 2020
Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin.
The Journal of biological chemistry
Mohan HM,Yang B,Dean NA,Raghavan M
PA3-900 was used in Western Blot to show that calreticulin (CRT), an endoplasmic reticulum (ER) glycoprotein chaperone, promotes the secretory trafficking of ATZ, enhancing the media:cell ratio.
Fri Dec 04 00:00:00 UTC 2020
Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity.
The Journal of cell biology
Tiscione SA,Vivas O,Ginsburg KS,Bers DM,Ory DS,Santana LF,Dixon RE,Dickson EJ
PA3-900 was used in Western Blot to highlight lysosomes as a crucial signalling platform responsible for tuning ER Ca2+ signalling, store-operated Ca2+ entry, and synaptic architecture in health and disease.
Mon Dec 02 00:00:00 UTC 2019
Integrins and ERp57 Coordinate to Regulate Cell Surface Calreticulin in Immunogenic Cell Death.
Frontiers in oncology
Liu CC,Leclair P,Pedari F,Vieira H,Monajemi M,Sly LM,Reid GS,Lim CJ
PA3-900 was used in Western Blotting to characterize the roles of ERp57 and α-integrins as calreticulin-interacting proteins that coordinately regulate calreticulin translocation from the ER to the surface during immunogenic cell death.
Wed Sep 30 00:00:00 UTC 2020
Dissociation of membrane-chromatin contacts is required for proper chromosome segregation in mitosis.
Molecular biology of the cell
Champion L,Pawar S,Luithle N,Ungricht R,Kutay U
PA3-900 was used in Immunocytochemistry-immunoflourescence to report on the consequences of impaired NE removal from chromatin for cell division of human cells.
Fri Feb 15 00:00:00 UTC 2019
Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity.
Scientific reports
Rossi A,Dupaty L,Aillot L,Zhang L,Gallien C,Hallek M,Odenthal M,Adriouch S,Salvetti A,Büning H
PA3-900 was used in Western Blotting to perform an in-depth analysis using human monocyte-derived immature DC as a model to study AAV vectors of various serotypes.
Wed Mar 06 00:00:00 UTC 2019
The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide.
International journal of molecular sciences
Pandya UM,Egbuta C,Abdullah Norman TM,Chiang CE,Wiersma VR,Panchal RG,Bremer E,Eggleton P,Gold LI
PA3-900 was used in an ELISA assay to show that recombinant and native human placental CRT strongly interacts with LPS in solution, solid phase, and the surface of gram-negative and gram-positive bacteria.
Fri Jan 18 00:00:00 UTC 2019
The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide.
International journal of molecular sciences
Pandya UM,Egbuta C,Abdullah Norman TM,Chiang CE,Wiersma VR,Panchal RG,Bremer E,Eggleton P,Gold LI
PA3-900 was used in an ELISA assay to show that recombinant and native human placental CRT strongly interacts with LPS in solution, solid phase, and the surface of gram-negative and gram-positive bacteria.
Fri Jan 18 00:00:00 UTC 2019
ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases.
Cells
Anwar T,Liu X,Suntio T,Marjamäki A,Biazik J,Chan EYW,Varjosalo M,Eskelinen EL
PA3-900 was used in Immunohistochemistry to show, under basal conditions, ULK1 and ULK2 facilitate the enrichment of Beclin 1 on the ER and may drive autophagosome biogenesis.
Fri May 17 00:00:00 UTC 2019
SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition.
Cell death and differentiation
Cieri D,Vicario M,Giacomello M,Vallese F,Filadi R,Wagner T,Pozzan T,Pizzo P,Scorrano L,Brini M,Calì T
PA3-900 was used in Immunocytochemistry to report a split-GFP-based contact site sensor (SPLICS) engineered to fluoresce when organelles are in proximity.
Fri Jun 01 00:00:00 UTC 2018
Drug-Induced Senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans-Presentation.
Cancer immunology research
Borrelli C,Ricci B,Vulpis E,Fionda C,Ricciardi MR,Petrucci MT,Masuelli L,Peri A,Cippitelli M,Zingoni A,Santoni A,Soriani A
PA3-900 was used in Western Blotting to demonstrate that low doses of chemotherapeutic drugs induce tumour cell senescence and a senescence-associated secretory phenotype thus promoting IL15 trans-presentation to NK cells leading to their activation and proliferation.
Sun Jul 01 00:00:00 UTC 2018
Cytosolic Processing Governs TAP-Independent Presentation of a Critical Melanoma Antigen.
Journal of immunology (Baltimore, Md. : 1950)
Vigneron N,Ferrari V,Van den Eynde BJ,Cresswell P,Leonhardt RM
PA3-900 was used in Western Blot to show antimelanoma vaccine candidate PMEL209-217 is robustly presented by various TAP- and/or tapasin-deficient cell lines.
Mon Oct 01 00:00:00 UTC 2018
Zinc deficiency causes delayed ATP clearance and adenosine generation in rats and cell culture models.
Communications biology
Takeda TA,Miyazaki S,Kobayashi M,Nishino K,Goto T,Matsunaga M,Ooi M,Shirakawa H,Tani F,Kawamura T,Komai M,Kambe T
PA3-900 was used in Western Blotting to examine whether zinc deficiency affects extracellular adenine-nucleotide metabolism.
Sat Jan 11 00:00:00 UTC 2020
Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I.
The Journal of biological chemistry
Arshad N,Cresswell P
PA3-900 was used in Immunoprecipitation to indicate that CRT-FS cannot mediate calreticulin's peptide loading function in the peptide loading complex.
Fri Jun 22 00:00:00 UTC 2018
Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer.
Journal of experimental & clinical cancer research : CR
Salaroglio IC,Gazzano E,Abdullrahman A,Mungo E,Castella B,Abd-Elrahman GEFA,Massaia M,Donadelli M,Rubinstein M,Riganti C,Kopecka J
PA3-900 was used in Western Blotting to suggest that preventing C/EBP-Β LIP degradation by lysosome and proteasome inhibitors triggers multiple virtuous circuitries that restore ER-dependent apoptosis, down-regulate Pgp and re-activate the DC/CD8+T-lymphocytes response against triple negative breast cancer.
Tue Nov 27 00:00:00 UTC 2018
Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune-environment.
Oncoimmunology
Riganti C,Lingua MF,Salaroglio IC,Falcomatà C,Righi L,Morena D,Picca F,Oddo D,Kopecka J,Pradotto M,Libener R,Orecchia S,Bironzo P,Comunanza V,Bussolino F,Novello S,Scagliotti GV,Di Nicolantonio F,Taulli R
PA3-900 was used in Flow Cytometry to propose that, among novel drugs, BBIs should be investigated for MPM treatment for their combined activity on both tumor cells and surrounding immune-environment.
Wed Nov 09 00:00:00 UTC 2022
Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR.
Cell reports
Hangen E,Cordelières FP,Petersen JD,Choquet D,Coussen F
PA3-900 was used in Immunocytochemistry to indicate that AMPA receptor intracellular transport is highly regulated during synaptic plasticity and likely controls AMPAR numbers at the plasma membrane.
Tue Jul 24 00:00:00 UTC 2018
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.
eLife
Menzies SA,Volkmar N,van den Boomen DJ,Timms RT,Dickson AS,Nathan JA,Lehner PJ
PA3-900 was used in Western Blotting to reveal a critical role for the sterol-responsive RNF145 in HMGCR regulation and elucidate the complexity of sterol-accelerated HMGCR degradation.
Thu Dec 13 00:00:00 UTC 2018
Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.
The Journal of nutritional biochemistry
Granato M,Rizzello C,Gilardini Montani MS,Cuomo L,Vitillo M,Santarelli R,Gonnella R,D'Orazi G,Faggioni A,Cirone M
PA3-900 was used in flow cytometry to show that quercetin inhibits the PI3K/AKT/mTOR and STAT3 pathways in primary effusion lymphoma
Wed Mar 01 00:00:00 UTC 2017
A novel approach to assess the ubiquitin-fold modifier 1-system in cells.
FEBS letters
Ishimura R,Obata M,Kageyama S,Daniel J,Tanaka K,Komatsu M
PA3900 was used in immunocytochemistry to discuss the pathophysiological role of the UFM1-system
Sun Jan 01 00:00:00 UTC 2017
Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology.
Neuron
Ruegsegger C,Stucki DM,Steiner S,Angliker N,Radecke J,Keller E,Zuber B,Rüegg MA,Saxena S
PA3-900 was used in immunohistochemistry to report that impaired mTORC1-Homer-3 activity underlies Purkinje cells susceptibility in spinocerebellar ataxia type 1
Wed Jan 06 00:00:00 UTC 2016
α-Integrin expression and function modulates presentation of cell surface calreticulin.
Cell death & disease
Liu CC,Leclair P,Monajemi M,Sly LM,Reid GS,Lim CJ
PA3-900 was used in western blot to determine modulation of presentation of cell surfaced calreticulin by alpha-integrin function and expression
Thu Jun 16 00:00:00 UTC 2016
A novel multi-drug metronomic chemotherapy significantly delays tumor growth in mice.
Journal of translational medicine
Tagliamonte M,Petrizzo A,Napolitano M,Luciano A,Rea D,Barbieri A,Arra C,Maiolino P,Tornesello M,Ciliberto G,Buonaguro FM,Buonaguro L
PA3-900 was used in flow cytometry to study how a novel multi-drug metronomic chemotherapy can delay tumor growth in mice significantly
Wed Feb 24 00:00:00 UTC 2016
Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS.
Nature neuroscience
Filézac de L'Etang A,Maharjan N,Cordeiro Braña M,Ruegsegger C,Rehmann R,Goswami A,Roos A,Troost D,Schneider BL,Weis J,Saxena S
PA3-900 was used in immunohistochemistry to characterize the endoplasmic reticulum in motor neuron subtypes
Sun Feb 01 00:00:00 UTC 2015
Calreticulin levels determine onset of early muscle denervation by fast motoneurons of ALS model mice.
Neurobiology of disease
Bernard-Marissal N,Sunyach C,Marissal T,Raoul C,Pettmann B
PA3-900 was used in immunohistochemistry to examine the involvement of calreticulin in the neurodegeration in ALS model mice
Thu Jan 01 00:00:00 UTC 2015
Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression.
Oncotarget
Granato M,Gilardini Montani MS,Filardi M,Faggioni A,Cirone M
PA3-900 was used in flow cytometry to characterize immunogenic PEL cell death, revertion of PEL-induced immune suppression, and stimulation of DCs all triggered by capsaicin
Tue Oct 06 00:00:00 UTC 2015
Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.
The Journal of cell biology
Cherepanova NA,Shrimal S,Gilmore R
PA3-900 was used in western blot to determine how N-glycosylation of cysteine-proximal acceptor sites in glycoproteins requires oxidoreductase activity
Mon Aug 18 00:00:00 UTC 2014
Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.
The Journal of biological chemistry
Blin S,Chatelain FC,Feliciangeli S,Kang D,Lesage F,Bichet D
PA3-900 was used in immunocytochemistry to study tandem pore domain halothane-inhibited K(+) channel 1 (THIC1) and THIC2 interactions and localization
Fri Oct 10 00:00:00 UTC 2014
Serum levels of calreticulin in correlation with disease activity in patients with rheumatoid arthritis.
Journal of clinical immunology
Ni M,Wei W,Wang Y,Zhang N,Ding H,Shen C,Zheng F
PA3-900 was used in western blot to study the correlation between serum calreticulin levels and rheumatoid arthritis disease activity
Mon Jul 01 00:00:00 UTC 2013
Human T cell leukemia virus type 2 tax-mediated NF-κB activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO.
Journal of virology
Journo C,Bonnet A,Favre-Bonvin A,Turpin J,Vinera J,Côté E,Chevalier SA,Kfoury Y,Bazarbachi A,Pique C,Mahieux R
PA3-900 was used in immunocytochemistry to study the mechanism by which Tax-2 activates NFkB
Tue Jan 01 00:00:00 UTC 2013
FRET-based sensor analysis reveals caveolae are spatially distinct Ca2+ stores in endothelial cells.
Cell calcium
Isshiki M,Nishimoto M,Mizuno R,Fujita T
PA3-900 was used in immunocytochemistry to study the role of caveolae as endothelial cell Ca(2+) stores using fluorescent imaging
Sun Dec 01 00:00:00 UTC 2013
Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.
The Journal of biological chemistry
Chatelain FC,Bichet D,Feliciangeli S,Larroque MM,Braud VM,Douguet D,Lesage F
PA3-900 was used in immunocytochemistry to study ER retention and low intrinsic acticity at the plasma membrane as explanatons for the lack of activity of heterologously expressed THIK2
Fri Dec 06 00:00:00 UTC 2013
Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Gabillet J,Millet A,Pederzoli-Ribeil M,Tacnet-Delorme P,Guillevin L,Mouthon L,Frachet P,Witko-Sarsat V
PA3-900 was used in flow cytometry to study the role of proteinase 3 in promoting inflammation and autoimmunity
Sat Sep 01 00:00:00 UTC 2012
Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.
Journal of cell science
Ohbayashi N,Maruta Y,Ishida M,Fukuda M
PA3-900 was used in western blot to study the mechanism by which melanoregulin regulates retrograde transport of melanosomes
Thu Mar 15 00:00:00 UTC 2012
A conserved region in the prM protein is a critical determinant in the assembly of flavivirus particles.
The Journal of general virology
Yoshii K,Igarashi M,Ichii O,Yokozawa K,Ito K,Kariwa H,Takashima I
PA3-900 was used in immunocytochemistry to investigate the mechanism for the assembly of flaviviruses
Sun Jan 01 00:00:00 UTC 2012
Structural and functional plasticity of subcellular tethering, targeting and processing of RPGRIP1 by RPGR isoforms.
Biology open
Patil H,Guruju MR,Cho KI,Yi H,Orry A,Kim H,Ferreira PA
PA3-900 was used in western blot to investigate the functional relationships between RPGR and RPGRIP1
Wed Feb 15 00:00:00 UTC 2012
Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc.
Medical molecular morphology
Yokoyama A,Nomura R,Kurosumi M,Shimomura A,Onouchi T,Iizuka-Kogo A,Smits R,Fodde R,Itoh M,Senda T
PA3-900 was used in immunohistochemistry to study the functions of the C-terminus of Apc protein in thyroid using Apc 1638T/1638T mice that express Apc lacking the C-terminal region
Fri Jun 01 00:00:00 UTC 2012
Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatus.
Traffic (Copenhagen, Denmark)
Thorne C,Eccles RL,Coulson JM,Urbé S,Clague MJ
PA3-900 was used in immunocytochemistry to investigate the subcellular distribution of USP33 isoforms
Tue Nov 01 00:00:00 UTC 2011
Role of Rab1b in COPII dynamics and function.
European journal of cell biology
Slavin I,García IA,Monetta P,Martinez H,Romero N,Alvarez C
PA3-900 was used in immunocytochemistry to investigate the influence of Rab1b on COPII association/dissociation kinetics at the endoplasmic reticulum exit sites
Fri Apr 01 00:00:00 UTC 2011
The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells.
Cancer biology & therapy
Bobilev I,Novik V,Levi I,Shpilberg O,Levy J,Sharoni Y,Studzinski GP,Danilenko M
PA3-900 was used in western blot to investigate the effect of Nrf2 transcription factor on myeloid differentiation
Tue Feb 01 00:00:00 UTC 2011
Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase.
Biochemical and biophysical research communications
Andre B,Duterme C,Van Moer K,Mertens-Strijthagen J,Jadot M,Flamion B
PA3-900 was used in western blot to investigate the localization of hyaluronidase Hyal2 in cultured cells
Fri Jul 22 00:00:00 UTC 2011
'IntraCell' plugin for assessment of intracellular localization of nano-delivery systems and their targeting to the individual organelles.
Biochemical and biophysical research communications
Sneh-Edri H,Stepensky D
PA3-900 was used in immunocytochemistry to develop a software system to evaluate the intracellular delivery of drugs
Fri Feb 11 00:00:00 UTC 2011
Loss of membrane targeting of Vangl proteins causes neural tube defects.
Biochemistry
Iliescu A,Gravel M,Horth C,Kibar Z,Gros P
PA3-900 was used in immunocytochemistry to investigate the role of VANGL1 and 2 mutations on neural tube development
Tue Feb 08 00:00:00 UTC 2011
Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein.
Histochemistry and cell biology
Nomura R,Orii M,Senda T
PA3-900 was used in western blot to investigate the cellular distribution and function of calreticulin-2
Wed Jun 01 00:00:00 UTC 2011
Secretion of novel SEL1L endogenous variants is promoted by ER stress/UPR via endosomes and shed vesicles in human cancer cells.
PloS one
Cattaneo M,Lotti LV,Martino S,Alessio M,Conti A,Bachi A,Mariani-Costantini R,Biunno I
PA3-900 was used in immunocytochemistry to study the cell-specific expression and functions of ER receptor variants
Thu Feb 17 00:00:00 UTC 2011
The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function.
Medical molecular morphology
Yokoyama A,Nomura R,Kurosumi M,Shimomura A,Onouchi T,Iizuka-Kogo A,Smits R,Oda N,Fodde R,Itoh M,Senda T
PA3-900 was used in immunohistochemistry to investigate the role of Apc C-terminus during the development of thyroid glands
Thu Dec 01 00:00:00 UTC 2011
Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1β release in human macrophages.
Autophagy
Petrovski G,Ayna G,Majai G,Hodrea J,Benko S,Mádi A,Fésüs L
PA3-900 was used in Western Blotting to find that during engulfment of MCF-7 cells undergoing autophagic death, IL-1β is secreted in a MyD88-independent manner, triggering an immunogenic response.
Tue Mar 01 00:00:00 UTC 2011
Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis.
The Journal of biological chemistry
Kopil CM,Vais H,Cheung KH,Siebert AP,Mak DD,Foskett JK,Neumar RW
PA3-900 was used in western blot to investigate the role of the calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor in intracellular Ca2+ homeostasis
Fri Oct 14 00:00:00 UTC 2011
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice.
Acta neuropathologica
de Waard MC,van der Pluijm I,Zuiderveen Borgesius N,Comley LH,Haasdijk ED,Rijksen Y,Ridwan Y,Zondag G,Hoeijmakers JH,Elgersma Y,Gillingwater TH,Jaarsma D
PA3-900 was used in immunocytochemistry to investigate the role of DNA damage and genotoxic stress in neuromuscular disorders
Fri Oct 01 00:00:00 UTC 2010
Dysferlin overexpression in skeletal muscle produces a progressive myopathy.
Annals of neurology
Glover LE,Newton K,Krishnan G,Bronson R,Boyle A,Krivickas LS,Brown RH
PA3-900 was used in western blot to characterize the effect of dysferlin level on myopathy
Mon Mar 01 00:00:00 UTC 2010
A mechanism of release of calreticulin from cells during apoptosis.
Journal of molecular biology
Tarr JM,Young PJ,Morse R,Shaw DJ,Haigh R,Petrov PG,Johnson SJ,Winyard PG,Eggleton P
PA3-900 was used in western blot to study the calreticulin release during apoptosis
Fri Sep 03 00:00:00 UTC 2010
Functional analysis of recombinant calreticulin fragment 39-272: implications for immunobiological activities of calreticulin in health and disease.
Journal of immunology (Baltimore, Md. : 1950)
Hong C,Qiu X,Li Y,Huang Q,Zhong Z,Zhang Y,Liu X,Sun L,Lv P,Gao XM
PA3-900 was used in western blot to investigate the role of a calreticulin fragment in the immune system
Fri Oct 15 00:00:00 UTC 2010
Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).
Cell cycle (Georgetown, Tex.)
Wang X,Gocek E,Novik V,Harrison JS,Danilenko M,Studzinski GP
PA3-900 was used in western blot to study the enhancement of the anti-leukemia effect of silibinin and 1,25-dihydroxyvitamin D3 by inhibiting Cot1/Tlp2
Mon Nov 15 00:00:00 UTC 2010
Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM).
Cell stress & chaperones
Gilady SY,Bui M,Lynes EM,Benson MD,Watts R,Vance JE,Simmen T
PA3-900 was used in western blot to study the redox requirements for Ero1alpha to localize to the mitochondria-associated membrane
Wed Sep 01 00:00:00 UTC 2010
Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-κB activation.
Virology
Avesani F,Romanelli MG,Turci M,Di Gennaro G,Sampaio C,Bidoia C,Bertazzoni U,Bex F
PA3-900 was used in immunocytochemistry to study the role of HTLV Tax-1 and Tax-2 in the disregulation of the NFkappaB pathway.
Sun Dec 05 00:00:00 UTC 2010
Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.
Biochemistry
Gravel M,Iliescu A,Horth C,Apuzzo S,Gros P
PA3-900 was used in immunocytochemistry to investigate the mechanism of neural tube abnormalities in loop-tail mice
Tue Apr 27 00:00:00 UTC 2010
Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells.
Nutrition and cancer
Pesakhov S,Khanin M,Studzinski GP,Danilenko M
PA3-900 was used in western blot to investigate the effect of dietary plant polyphenol combinations on acute myeloid leukemia
Mon Nov 22 00:00:00 UTC 2010
Selective fusion of azurophilic granules with Leishmania-containing phagosomes in human neutrophils.
The Journal of biological chemistry
Mollinedo F,Janssen H,de la Iglesia-Vicente J,Villa-Pulgarin JA,Calafat J
PA3-900 was used in immunocytochemistry to investigate the relationship between Leishmania-containing phagosomes and azurophilic granules in neutrophils
Fri Nov 05 00:00:00 UTC 2010
Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system.
Free radical biology & medicine
Linnewiel K,Ernst H,Caris-Veyrat C,Ben-Dor A,Kampf A,Salman H,Danilenko M,Levy J,Sharoni Y
PA3-900 was used in western blot to study the SAR of carotenoid derivatives in relation to activation of the EpRE/ARE transcription system and induction of phase II detoxification enzymes
Tue Sep 01 00:00:00 UTC 2009
A Legionella pneumophila effector protein encoded in a region of genomic plasticity binds to Dot/Icm-modified vacuoles.
PLoS pathogens
Ninio S,Celli J,Roy CR
PA3-900 was used in immunocytochemistry to study the ability of Legionella pneumophila effector protein PieA to bind to Dot/Icm-modified vacuoles
Thu Jan 01 00:00:00 UTC 2009
Chronic stress elicits prolonged activation of alpha-MSH secretion and subsequent degeneration of melanotroph.
Journal of neurochemistry
Ogawa T,Shishioh-Ikejima N,Konishi H,Makino T,Sei H,Kiryu-Seo S,Tanaka M,Watanabe Y,Kiyama H
PA3-900 was used in immunohistochemistry to study the effect of chronic stress on alpha-MSH secretion and melanotroph degeneration
Mon Jun 01 00:00:00 UTC 2009
Differential cell death regulation between adult-unloaded and aged rat soleus muscle.
Mechanisms of ageing and development
Ogata T,Machida S,Oishi Y,Higuchi M,Muraoka I
PA3-900 was used in western blot to study the different regulation of cell death in aged atrophy and un-load atrophy in rat skeletal muscle
Fri May 01 00:00:00 UTC 2009
Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates.
Journal of proteome research
Bivi N,Bereszczak JZ,Romanello M,Zeef LA,Delneri D,Quadrifoglio F,Moro L,Brancia FL,Tell G
PA3-900 was used in western blot to study the mRNA and protein changes in osteocytes with nitrogen-containing bisphosphonate treatment
Sun Mar 01 00:00:00 UTC 2009
The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival.
Molecular biology of the cell
Vafiadaki E,Arvanitis DA,Pagakis SN,Papalouka V,Sanoudou D,Kontrogianni-Konstantopoulos A,Kranias EG
PA3-900 was used in western blot to study the interaction between the anti-apoptotic protein HAX-1 and SERCA2 and its role in promoting cell survival
Thu Jan 01 00:00:00 UTC 2009
Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate.
The Journal of biological chemistry
Cattaneo M,Lotti LV,Martino S,Cardano M,Orlandi R,Mariani-Costantini R,Biunno I
PA3-900 was used in immunocytochemistry to characterize two secreted isoforms of SEL1L
Fri Apr 24 00:00:00 UTC 2009
Intracellular localization of Brucella abortus and Francisella tularensis in primary murine macrophages.
Methods in molecular biology (Clifton, N.J.)
Celli J
PA3-900 was used in immunocytochemistry to study intracellular cycles of Brucella abortus and Francisella tularensis in murine macrophages
Wed Jul 02 00:00:00 UTC 2008
Selective loading of high-affinity peptides onto major histocompatibility complex class I molecules by the tapasin-ERp57 heterodimer.
Nature immunology
Wearsch PA,Cresswell P
PA3-900 was used in western blot to investigate the role of tapasin-ERp57 for MHC class I and peptide ligation
Wed Aug 01 00:00:00 UTC 2007
Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP.
Cell death and differentiation
Mimura N,Hamada H,Kashio M,Jin H,Toyama Y,Kimura K,Iida M,Goto S,Saisho H,Toshimori K,Koseki H,Aoe T
PA3-900 was used in western blot to study the effect of mutant BiP on endoplasmic reticulum quality control and biosynthesis of pulmonary surfactant in mice
Wed Aug 01 00:00:00 UTC 2007
Influence of Ki-ras-driven oncogenic transformation on the protein network of murine fibroblasts.
Proteomics
Recktenwald CV,Mendler S,Lichtenfels R,Kellner R,Seliger B
PA3-900 was used in western blot to investigate the influence of Ki-ras on protein expression in murine fibroblasts
Thu Feb 01 00:00:00 UTC 2007
Lycopene and other carotenoids inhibit estrogenic activity of 17beta-estradiol and genistein in cancer cells.
Breast cancer research and treatment
Hirsch K,Atzmon A,Danilenko M,Levy J,Sharoni Y
PA3-900 was used in western blot to study whether lycopene and other carotenoids can inhibit the estrogenic activity of 17beta-estradiol and genistein in cancer cells
Wed Aug 01 00:00:00 UTC 2007
Expression of the Longin domain of TI-VAMP impairs lysosomal secretion and epithelial cell migration.
Biology of the cell
Proux-Gillardeaux V,Raposo G,Irinopoulou T,Galli T
PA3-900 was used in western blot to investigate the effect of TI-VAMP Longin domain on lysosomal secretion and epithelial cell migration
Tue May 01 00:00:00 UTC 2007
Impact of two novel mutations on the structure and function of human myeloperoxidase.
The Journal of biological chemistry
Goedken M,McCormick S,Leidal KG,Suzuki K,Kameoka Y,Astern JM,Huang M,Cherkasov A,Nauseef WM
PA3-900 was used in western blot to study the impact of two novel mutations on the structure and function of human myeloperoxidase.
Fri Sep 21 00:00:00 UTC 2007
Isolation of endoplasmic reticulum, mitochondria, and mitochondria-associated membrane fractions from transfected cells and from human cytomegalovirus-infected primary fibroblasts.
Current protocols in cell biology
Bozidis P,Williamson CD,Colberg-Poley AM
PA3-900 was used in western blot to develop procedures for the preparation of endoplasmic reticulum, mitochondria, and mitochondria-associated membrane fractions
Sat Dec 01 00:00:00 UTC 2007
Cleavage of endoplasmic reticulum proteins in hepatocellular carcinoma: Detection of generated fragments in patient sera.
Gastroenterology
Chignard N,Shang S,Wang H,Marrero J,Bréchot C,Hanash S,Beretta L
PA3-900 was used in western blot to investigate new molecular markers for hepatocellular carcinoma
Thu Jun 01 00:00:00 UTC 2006
Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells.
Proceedings of the National Academy of Sciences of the United States of America
Snapp EL,Sharma A,Lippincott-Schwartz J,Hegde RS
PA3-900 was used in western blot to demonstrate the organization and dynamics of an ER chaperone in the endoplasmic reticulum of live cells
Tue Apr 25 00:00:00 UTC 2006
Polarized apical sorting of guanylyl cyclase C is specified by a cytosolic signal.
Traffic (Copenhagen, Denmark)
Hodson CA,Ambrogi IG,Scott RO,Mohler PJ,Milgram SL
PA3-900 was used in immunocytochemistry to study the mechanism of polarized apical sorting of guanylyl cyclase C in MDCK cells
Sat Apr 01 00:00:00 UTC 2006
Effects of aging on Ca2+ signaling in murine mesenteric arterial smooth muscle cells.
Mechanisms of ageing and development
del Corsso C,Ostrovskaya O,McAllister CE,Murray K,Hatton WJ,Gurney AM,Spencer NJ,Wilson SM
PA3-900 was used in immunocytochemistry to study the age-depended calcium signaling in murine mesenteric arterial smooth muscle cells
Sat Apr 01 00:00:00 UTC 2006
Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites.
Journal of cell science
Halbach A,Landgraf C,Lorenzen S,Rosenkranz K,Volkmer-Engert R,Erdmann R,Rottensteiner H
PA3-900 was used in immunocytochemistry to study the role of C-terminal PEX19-binding sites in the targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15
Thu Jun 15 00:00:00 UTC 2006
Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.
Molecular biology of the cell
Mitra S,Annamalai L,Chakraborty S,Johnson K,Song XH,Batra SK,Mehta PP
PA3-900 was used in immunocytochemistry to study the gap junction formation and degradation in human prostate cancer cells.
Fri Dec 01 00:00:00 UTC 2006
Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking.
The Journal of biological chemistry
Sun H,Liu X,Xiong Q,Shikano S,Li M
PA3-900 was used in western blot to study the effect of celastrol on cardiac Kir2.1 and hERG potassium channels.
Fri Mar 03 00:00:00 UTC 2006
Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.
The Journal of biological chemistry
Bowers K,Piper SC,Edeling MA,Gray SR,Owen DJ,Lehner PJ,Luzio JP
PA3-900 was used in western blot to investigate the role of mammalian ESCRTII in the degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I.
Fri Feb 24 00:00:00 UTC 2006
Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival.
Nature immunology
Arellano-Reynoso B,Lapaque N,Salcedo S,Briones G,Ciocchini AE,Ugalde R,Moreno E,Moriyón I,Gorvel JP
PA3-900 was used in immunocytochemistry to study the role of a cyclic beta-1,2-glucan Brucella virulence factor in intracellular survival
Wed Jun 01 00:00:00 UTC 2005
TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination.
The EMBO journal
Wu CJ,Conze DB,Li X,Ying SX,Hanover JA,Ashwell JD
PA3-900 was used in immunocytochemistry to study TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment
Wed May 18 00:00:00 UTC 2005
Mitochondrially targeted p53 has tumor suppressor activities in vivo.
Cancer research
Talos F,Petrenko O,Mena P,Moll UM
PA3-900 was used in immunocytochemistry to study the in vivo tumor suppressor activities of mitochondrially targeted p53
Tue Nov 01 00:00:00 UTC 2005
MAP-1 is a mitochondrial effector of Bax.
Proceedings of the National Academy of Sciences of the United States of America
Tan KO,Fu NY,Sukumaran SK,Chan SL,Kang JH,Poon KL,Chen BS,Yu VC
PA3-900 was used in western blot to investigate the role of MAP-1 for Bax functions in mitochondria
Tue Oct 11 00:00:00 UTC 2005
Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model.
Haematologica
Garwicz D,Lennartsson A,Jacobsen SE,Gullberg U,Lindmark A
PA3-900 was used in immunoprecipitation to study the anabolism of neutrophil serine proteases in a cellular myeloid differentiation model
Sat Jan 01 00:00:00 UTC 2005
Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates.
EMBO reports
Yoshida Y,Adachi E,Fukiya K,Iwai K,Tanaka K
PA3-900 was used in immunoprecipitation and western blot to study the recognition of N-glycans in unfolded substrates by glycoprotein-specific ubiquitin ligases
Tue Mar 01 00:00:00 UTC 2005
Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2.
Journal of lipid research
Stillemark-Billton P,Beck C,Borén J,Olofsson SO
PA3-900 was used in western blot to compare the two-step process and an apoB size-dependent lipidation process as to the production of different lipoproteins
Sat Jan 01 00:00:00 UTC 2005
Mucin granules are in close contact with tubular elements of the endoplasmic reticulum.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Perez-Vilar J,Ribeiro CM,Salmon WC,Mabolo R,Boucher RC
PA3-900 was used in immunohistochemistry to investigate mucin granules' spatial relationship with other organelles such as Golgi complex, endosomes/lysosomes and the endoplasmic reticulum (ER) in HT29-SHGFP-MUC5AC/CK mucous cells
Sat Oct 01 00:00:00 UTC 2005
The prion protein and its paralogue Doppel affect calcium signaling in Chinese hamster ovary cells.
Molecular biology of the cell
Brini M,Miuzzo M,Pierobon N,Negro A,Sorgato MC
PA3-900 was used in western blot to study the effect of the prion protein and its paralogue Doppel on calcium signaling in CHO cells
Wed Jun 01 00:00:00 UTC 2005
MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.
Molecular biology of the cell
Nakamura N,Fukuda H,Kato A,Hirose S
PA3-900 was used in western blot to identify membrane-associated RING-CH (MARCH) and its binding to syntaxin 6.
Fri Apr 01 00:00:00 UTC 2005
Transcription inhibition of oncogenic KRAS by a mutation-selective peptide nucleic acid conjugated to the PKKKRKV nuclear localization signal peptide.
Biochemistry
Cogoi S,Codognotto A,Rapozzi V,Meeuwenoord N,van der Marel G,Xodo LE
PA3-900 was used in western blot to study the transcriptional inhibition of oncogenic KRAS by a mutation-selective peptide nucleic acid conjugated to the PKKKRKV nuclear localization signal peptide
Tue Aug 09 00:00:00 UTC 2005
Different approaches for assaying melanosome transfer.
Pigment cell research
Berens W,Van Den Bossche K,Yoon TJ,Westbroek W,Valencia JC,Out CJ,Marie Naeyaert J,Hearing VJ,Lambert J
PA3-900 was used in immunocytochemistry to evaluate different approaches for assaying melanosome transfer to keratinocytes
Sat Oct 01 00:00:00 UTC 2005
Regulation of protein compartmentalization expands the diversity of protein function.
Developmental cell
Shaffer KL,Sharma A,Snapp EL,Hegde RS
PA3-900 was used in Western Blot to propose that regulation of protein translocation represents a potentially general mechanism for generating diversity of protein function.
Sat Oct 01 00:00:00 UTC 2005
Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.
The Journal of biological chemistry
Iwai M,Tateishi Y,Hattori M,Mizutani A,Nakamura T,Futatsugi A,Inoue T,Furuichi T,Michikawa T,Mikoshiba K
PA3-900 was used in immunocytochemistry to clone and characterize mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors including a novel type 2 receptor splice variant
Fri Mar 18 00:00:00 UTC 2005
Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.
The Journal of biological chemistry
Suzuki T,Ishihara K,Migaki H,Matsuura W,Kohda A,Okumura K,Nagao M,Yamaguchi-Iwai Y,Kambe T
PA3-900 was used in western blot to study the role of the ZnT5 and ZnT7 zinc transporters in the activation of GPI-anchored zinc-dependent alkaline phosphatases
Fri Jan 07 00:00:00 UTC 2005
C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors.
The Journal of biological chemistry
Coblitz B,Shikano S,Wu M,Gabelli SB,Cockrell LM,Spieker M,Hanyu Y,Fu H,Amzel LM,Li M
PA3-900 was used in immunohistochemistry to study the role of protein C-terminal recognition by 14-3-3 proteins in the surface expression of membrane receptors
Fri Oct 28 00:00:00 UTC 2005
An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer.
Cancer research
Hong SH,Misek DE,Wang H,Puravs E,Giordano TJ,Greenson JK,Brenner DE,Simeone DM,Logsdon CD,Hanash SM
PA3-900 was used in western blot to study the autoantibodies to calreticulin isoforms in pancreatic cancer.
Sun Aug 01 00:00:00 UTC 2004
Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gonzalez-Alegre P,Paulson HL
PA3-900 was used in western blot to investigate the effect of mutant torsinA on nuclear envelope in Torsion dystonia-1 dystonia.
Wed Mar 17 00:00:00 UTC 2004
Membrane fusion of secretory vesicles of the sea urchin egg in the absence of NSF.
Journal of cell science
Whalley T,Timmers K,Coorssen J,Bezrukov L,Kingsley DH,Zimmerberg J
PA3-900 was used in western blot to investigate the role of NSF in membrane fusion of secretory vesicles in sea urchin eggs
Sat May 01 00:00:00 UTC 2004
A new tool for plant cell biology: in vivo antibody uptake in plant protoplasts.
Plant cell reports
Brière C,Barthou H,Petitprez M
PA3-900 was used in immunocytochemistry to study the in vivo uptake of antibodies into plant protoplasts
Thu Jul 01 00:00:00 UTC 2004
Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7.
Molecular microbiology
Gruenheid S,Sekirov I,Thomas NA,Deng W,O'Donnell P,Goode D,Li Y,Frey EA,Brown NF,Metalnikov P,Pawson T,Ashman K,Finlay BB
PA3-900 was used in western blot to study NleA, a non-LEE-encoded type III virulence factor of enterohaemorrhagic Escherichia coli O157:H7
Mon Mar 01 00:00:00 UTC 2004
Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985)
Glover L,Heffron JJ,Ohlendieck K
PA3-900 was used in western blot to investigate the importance of RyR2 complex formation in the development of a metabolic crisis in malignant hyperthermia
Thu Jan 01 00:00:00 UTC 2004
Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication.
The Journal of biological chemistry
de Jong AS,Melchers WJ,Glaudemans DH,Willems PH,van Kuppeveld FJ
PA3-900 was used in immunocytochemistry to investigate the effects of linker insertion and substitution mutations in different regions of the 2B protein on homo-multimerization, increasing membrane permeability, subcellular localization, and virus replication.
Fri May 07 00:00:00 UTC 2004
HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RII alpha regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling.
European journal of biochemistry
Demaugre F,Philippe Y,Sar S,Pileire B,Christa L,Lasserre C,Brechot C
PA3-900 was used in immunocytochemistry to study the mechanism by which the C-type lectin HIP/HAP overexpressed in hepatocellular carcinoma alters cAMP-dependent protein kinase signalling
Fri Oct 01 00:00:00 UTC 2004
N-glycosylation is crucial for folding, trafficking, and stability of human tripeptidyl-peptidase I.
The Journal of biological chemistry
Wujek P,Kida E,Walus M,Wisniewski KE,Golabek AA
PA3-900 was used in immunocytochemistry to investigate the role of N-glycosylation in the folding, trafficking, and stability of human tripeptidyl-peptidase I.
Fri Mar 26 00:00:00 UTC 2004
Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons.
The Journal of biological chemistry
Cai W,Hisatsune C,Nakamura K,Nakamura T,Inoue T,Mikoshiba K
PA3-900 was used in western blot to study the effect of chronic NMDAR blockade on IP3R1 expression.
Fri May 28 00:00:00 UTC 2004
ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.
Nature
Guermonprez P,Saveanu L,Kleijmeer M,Davoust J,Van Endert P,Amigorena S
PA3-900 was used in western blot to study the role of endoplasmic reticulum-phagosome fusion in dendritic cells
Thu Sep 25 00:00:00 UTC 2003
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum.
The Journal of experimental medicine
Celli J,de Chastellier C,Franchini DM,Pizarro-Cerda J,Moreno E,Gorvel JP
PA3-900 was used in immunohistochemistry to investigate the mechanism of the Brucella's survival of macrophage killing.
Mon Aug 18 00:00:00 UTC 2003
Altered levels and regulation of stathmin in paclitaxel-resistant ovarian cancer cells.
Oncogene
Balachandran R,Welsh MJ,Day BW
PA3-900 was used in western blot to investigate the changes of stathmin in specific cancer cell lines
Thu Dec 04 00:00:00 UTC 2003
Human T-cell lymphotropic virus type 1 p12I enhances interleukin-2 production during T-cell activation.
Journal of virology
Ding W,Kim SJ,Nair AM,Michael B,Boris-Lawrie K,Tripp A,Feuer G,Lairmore MD
PA3-900 was used in immunocytochemistry to demonstrate the effect of human T-cell lymphotropic virus p12I protein on IL-2 production .
Wed Oct 01 00:00:00 UTC 2003
N-linked oligosaccharide processing, but not association with calnexin/calreticulin is highly correlated with endoplasmic reticulum-associated degradation of antithrombin Glu313-deleted mutant.
Archives of biochemistry and biophysics
Tokunaga F,Hara K,Koide T
PA3-900 was used in western blot to examine the endoplasmic reticulum-associated degradation pathway
Sat Mar 15 00:00:00 UTC 2003
Involvement of the endoplasmic reticulum in peroxisome formation.
Molecular biology of the cell
Geuze HJ,Murk JL,Stroobants AK,Griffith JM,Kleijmeer MJ,Koster AJ,Verkleij AJ,Distel B,Tabak HF
PA3-900 was used in immunohistochemistry to investigate the role of endoplasmic reticulum in the formation of peroxisome.
Tue Jul 01 00:00:00 UTC 2003
A glucose-6-phosphate hydrolase, widely expressed outside the liver, can explain age-dependent resolution of hypoglycemia in glycogen storage disease type Ia.
The Journal of biological chemistry
Shieh JJ,Pan CJ,Mansfield BC,Chou JY
PA3-900 was used in immunocytochemistry to study the mechanism of blood glucose homeostasis in type Ia glycogen storage disease.
Fri Nov 21 00:00:00 UTC 2003
N-linked glycosylation is critical for the plasma membrane localization of nephrin.
Journal of the American Society of Nephrology : JASN
Yan K,Khoshnoodi J,Ruotsalainen V,Tryggvason K
PA3-900 was used in immunocytochemistry to investigate the role of N-linked glycosylation for the plasma membrane localization of nephrin
Wed May 01 00:00:00 UTC 2002
Cellular location of proteins related to iron absorption and transport.
American journal of hematology
Simovich MJ,Conrad ME,Umbreit JN,Moore EG,Hainsworth LN,Smith HK
PA3-900 was used in immunocytochemistry to study the subcellular localization of proteins related to iron absorption and transport
Fri Mar 01 00:00:00 UTC 2002
Human T-cell lymphotropic virus type 1 p12(I) expression increases cytoplasmic calcium to enhance the activation of nuclear factor of activated T cells.
Journal of virology
Ding W,Albrecht B,Kelley RE,Muthusamy N,Kim SJ,Altschuld RA,Lairmore MD
PA3-900 was used in immunoprecipitation to investigate the role of CT domain of HSV gE in the trans-Golgi network.
Tue Oct 01 00:00:00 UTC 2002
Identification of glycoprotein gpTRL10 as a structural component of human cytomegalovirus.
Journal of virology
Spaderna S,Blessing H,Bogner E,Britt W,Mach M
PA3-900 was used in immunocytochemistry to investigate a novel structural glycoprotein of HCMV gpTRL10.
Fri Feb 01 00:00:00 UTC 2002
Organizational diversity among distinct glycoprotein endoplasmic reticulum-associated degradation programs.
Molecular biology of the cell
Cabral CM,Liu Y,Moremen KW,Sifers RN
PA3-900 was used in immunocytochemistry to investigate the mechanism for glycoprotein endoplasmic reticulum-associated degradation program in cells of higher eukaryotes.
Thu Aug 01 00:00:00 UTC 2002
Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes.
The Journal of biological chemistry
Brosius U,Dehmel T,Gärtner J
PA3-900 was used in immunocytochemistry to show that human and rat PMP22 contains two distinct and nonoverlapping peroxisomal membrane targeting signals.
Fri Jan 04 00:00:00 UTC 2002
Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation.
The Journal of biological chemistry
Robin MA,Anandatheerthavarada HK,Biswas G,Sepuri NB,Gordon DM,Pain D,Avadhani NG
PA3-900 was used in western blot to study the bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation
Fri Oct 25 00:00:00 UTC 2002
Membrane topology of the hepatitis C virus NS2 protein.
The Journal of biological chemistry
Yamaga AK,Ou JH
PA3-900 was used in immunocytochemistry to conduct the topological studies on the hepatitis C virus NS2 protein.
Fri Sep 06 00:00:00 UTC 2002
Regulation of calreticulin expression during induction of differentiation in human myeloid cells. Evidence for remodeling of the endoplasmic reticulum.
The Journal of biological chemistry
Clark RA,Li SL,Pearson DW,Leidal KG,Clark JR,Denning GM,Reddick R,Krause KH,Valente AJ
PA3-900 was used in western blot to investigate what affects the expression of calreticulin during the induction of differentiation of HL-60 human myeloid cells.
Fri Aug 30 00:00:00 UTC 2002
Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation.
Blood
Chen F,Studzinski GP
pA3-900 was used in western blot to study the functional relationship between Cdk5 and p35Nck5a, and the role for this complex in monocytic differentiation.
Fri Jun 15 00:00:00 UTC 2001
Calreticulin is an interleukin-3-sensitive calcium-binding protein in human basophil leukocytes.
Allergy
Lyngholm JM,Nielsen HV,Holm M,Schiøtz PO,Johnsen AH
PA3-900 was used in western blot to study the role of calreticulin as an IL-3-sensitive calcium-binding protein in human basophil leukocytes
Mon Jan 01 00:00:00 UTC 2001
Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents.
Journal of the National Cancer Institute
Danilenko M,Wang X,Studzinski GP
PA3-900 was used in western blot to investigate the role of carnosic acid during monocytic differentiation of HL60-G cells
Wed Aug 15 00:00:00 UTC 2001
ER60/ERp57 forms disulfide-bonded intermediates with MHC class I heavy chain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lindquist JA,Hämmerling GJ,Trowsdale J
PA3-900 was used in western blot to investigate the interaction between ER60/ERp57 and MHC class I heavy chain
Fri Jun 01 00:00:00 UTC 2001
Expression of endoplasmic reticulum stress proteins during skeletal muscle disuse atrophy.
American journal of physiology. Cell physiology
Hunter RB,Mitchell-Felton H,Essig DA,Kandarian SC
PA3-900 was used in western blot to study the expression of endoplasmic reticulum stress proteins during skeletal muscle disuse atrophy
Mon Oct 01 00:00:00 UTC 2001
Defective nephrin trafficking caused by missense mutations in the NPHS1 gene: insight into the mechanisms of congenital nephrotic syndrome.
Human molecular genetics
Liu L,Doné SC,Khoshnoodi J,Bertorello A,Wartiovaara J,Berggren PO,Tryggvason K
PA3-900 was used in immunocytochemistry to study defective nephrin trafficking caused by missense mutations in the NPHS1 gene and its role in congenital nephrotic syndrome pathogenesis
Thu Nov 01 00:00:00 UTC 2001
nNOS in canine lower esophageal sphincter: colocalized with Cav-1 and Ca2+-handling proteins?
American journal of physiology. Gastrointestinal and liver physiology
Daniel EE,Jury J,Wang YF
PA3-900 was used in immunohistochemistry to investigate the colocalization of nNOS with Cav-1 and -handling proteins
Mon Oct 01 00:00:00 UTC 2001
Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism.
Proceedings of the National Academy of Sciences of the United States of America
Halaban R,Svedine S,Cheng E,Smicun Y,Aron R,Hebert DN
PA3-900 was used in immunoprecipitation to conclude that albinism is an ER retention disease.
Tue May 23 00:00:00 UTC 2000
Specific association of increased cyclin-dependent kinase 5 expression with monocytic lineage of differentiation of human leukemia HL60 cells.
Journal of leukocyte biology
Chen F,Rao J,Studzinski GP
PA3-900 was used in western blot to study the specific association of increased Cdk 5 expression with monocytic differentiation of human leukemia HL60 cells
Sat Apr 01 00:00:00 UTC 2000
HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.
Journal of immunology (Baltimore, Md. : 1950)
Wainwright SD,Biro PA,Holmes CH
PA3-900 was used in immunoprecipitation and western blot to study the expression pattern and possible functions of the HLA-F MHC class Ib protein
Sat Jan 01 00:00:00 UTC 2000
Rat sperm 2B1 glycoprotein (PH20) contains a C-terminal sequence motif for attachment of a glycosyl phosphatidylinositol anchor. Effects of endoproteolytic cleavage on hyaluronidase activity.
Biology of reproduction
Seaton GJ,Hall L,Jones R
PA3-900 was used in immunocytochemistry to investigate the attachment of sperm 2B1 glycoprotein with plasma membrane and regulation of its hyaluronidase activity through endoproteolytic cleavage
Thu Jun 01 00:00:00 UTC 2000
Calreticulin couples calcium release and calcium influx in integrin-mediated calcium signaling.
Molecular biology of the cell
Kwon MS,Park CS,Choi K,Ahnn J,Kim JI,Eom SH,Kaufman SJ,Song WK
PA3-900 was used in immunocytochemistry to demonstrate the interaction between calreticulin and integrin and its effect on calcium signaling.
Sat Apr 01 00:00:00 UTC 2000
Dissociation from BiP and retrotranslocation of unassembled immunoglobulin light chains are tightly coupled to proteasome activity.
Molecular biology of the cell
Chillarón J,Haas IG
PA3-900 was used in western blot to study the degradation process of the unassembled immunoglobulin light chains in a mouse plasmacytoma cell line.
Sat Jan 01 00:00:00 UTC 2000
Intracellular transport, assembly, and degradation of wild-type and disease-linked mutant gap junction proteins.
Molecular biology of the cell
VanSlyke JK,Deschenes SM,Musil LS
PA3-900 was used in western blot to study the roles of cx32 mutations on the pathogenesis of human peripheral neuropathy X-linked Charcot-Marie-Tooth disease.
Thu Jun 01 00:00:00 UTC 2000
Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at ser128.
The EMBO journal
Anandatheerthavarada HK,Biswas G,Mullick J,Sepuri NB,Otvos L,Pain D,Avadhani NG
PA3-900 was used in western blot to study the role of cAMP-dependent phosphorylation in the dual targeting of cytochrome P450 2B1 to endoplasmic reticulum and mitochondria
Fri Oct 15 00:00:00 UTC 1999
ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly.
The EMBO journal
Lindquist JA,Jensen ON,Mann M,Hämmerling GJ
PA3-900 was used in western blot to discover novel factors related to the assembly of MHC class I molecules
Wed Apr 15 00:00:00 UTC 1998
Differential modulation of SERCA2 isoforms by calreticulin.
The Journal of cell biology
John LM,Lechleiter JD,Camacho P
PA3-900 was used in immunocytochemistry to investigate the role of calreticulin in modulating SERCA2 isoforms and in glycoprotein maturation.
Mon Aug 24 00:00:00 UTC 1998
MHC class I molecules compete in the endoplasmic reticulum for access to transporter associated with antigen processing.
Journal of immunology (Baltimore, Md. : 1950)
Knittler MR,Gülow K,Seelig A,Howard JC
PA3-900 was used in western blot to investigate the association of rat MHC class I molecules with transporter associated with antigen processing
Tue Dec 01 00:00:00 UTC 1998
Spreading of the immune response from 52 kDaRo and 60 kDaRo to calreticulin in experimental autoimmunity.
Lupus
Kinoshita G,Keech CL,Sontheimer RD,Purcell A,McCluskey J,Gordon TP
PA3-900 was used in western blot to study the mechanism underlying the spread of the immune response from 52 kDaRo and 60 kDaRo to calreticulin in experimental autoimmunity
Thu Apr 02 00:00:00 UTC 1998
Calnexin association is not sufficient to protect T cell receptor alpha proteins from rapid degradation in CD4+CD8+ thymocytes.
The Journal of biological chemistry
Bennett MJ,Van Leeuwen JE,Kearse KP
PA3-900 was used in immunoprecipitation to investigate the rapid degradation of T cell receptor alpha proteins in CD4+CD8+ thymocytes
Fri Sep 11 00:00:00 UTC 1998
Calnexin associates with monomeric and oligomeric (disulfide-linked) CD3delta proteins in murine T lymphocytes.
The Journal of biological chemistry
Kearse KP
PA3-900 was used in immunoprecipitation to study the interaction between calnexin and CD3delta proteins in murine T lymphocytes
Fri Jun 05 00:00:00 UTC 1998
Calreticulin biosynthesis and processing in human myeloid cells: demonstration of signal peptide cleavage and N-glycosylation.
Blood
Denning GM,Leidal KG,Holst VA,Iyer SS,Pearson DW,Clark JR,Nauseef WM,Clark RA
PA3-900 was used in western blot to investigate the anabolism of calreticulin in human myeloid cells
Tue Jul 01 00:00:00 UTC 1997
Interactions between newly synthesized glycoproteins, calnexin and a network of resident chaperones in the endoplasmic reticulum.
The Journal of cell biology
Tatu U,Helenius A
PA3-900 was used in immunoprecipitation to characterize the resident endoplasmic reticulum chaperones and their functions .
Mon Feb 10 00:00:00 UTC 1997
Subcellular distribution of normal and mutant vitamin D receptors in living cells. Studies with a novel fluorescent ligand.
The Journal of biological chemistry
Barsony J,Renyi I,McKoy W
PA3-900 was used in immunocytochemistry to investigate the subcellular localization of vitamin D receptor (VDR) in living cells
Fri Feb 28 00:00:00 UTC 1997
Calnexin and calreticulin promote folding, delay oligomerization and suppress degradation of influenza hemagglutinin in microsomes.
The EMBO journal
Hebert DN,Foellmer B,Helenius A
PA3-900 was used in immunoprecipitation to investigate the efffect of calnexin and calreticulin on influenza hemagglutinin
Mon Jun 17 00:00:00 UTC 1996
Intracellular calcium stores and inositol 1,4,5-trisphosphate receptor in rat liver cells.
The Biochemical journal
Lièvremont JP,Hill AM,Tran D,Coquil JF,Stelly N,Mauger JP
PA3-900 was used in western blot to study the localization of the inositol 1,4,5-trisphosphate receptor in rat liver cells
Thu Feb 15 00:00:00 UTC 1996
Calreticulin expression in spinal motoneurons of the rat.
Journal of chemical neuroanatomy
Copray JC,Liem RS,Kernell D
PA3-900 was used in western blot to study the expression of calreticulin in rat spinal motoneurons
Mon Jul 01 00:00:00 UTC 1996
Calreticulin inhibits repetitive intracellular Ca2+ waves.
Cell
Camacho P,Lechleiter JD
PA3-900 was used in immunocytochemistry to investigate the role of CRT in IP3-mediated caclium signaling
Fri Sep 08 00:00:00 UTC 1995
Transient, lectin-like association of calreticulin with folding intermediates of cellular and viral glycoproteins.
Molecular biology of the cell
Peterson JR,Ora A,Van PN,Helenius A
PA3-900 was used in immunoprecipitation to study the possible role of calreticulin in glycoprotein folding
Fri Sep 01 00:00:00 UTC 1995
Cell surface calreticulin is a putative mannoside lectin which triggers mouse melanoma cell spreading.
The Journal of biological chemistry
White TK,Zhu Q,Tanzer ML
PA3-900 was used in western blot to investigate the role of cell surface calreticulin in mouse melanoma cell spreading
Fri Jul 07 00:00:00 UTC 1995
Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils.
Science (New York, N.Y.)
Stendahl O,Krause KH,Krischer J,Jerström P,Theler JM,Clark RA,Carpentier JL,Lew DP
PA3-900 was used in immunocytochemistry to assess the intracellular calcium distribution in phagocytosis
Fri Sep 02 00:00:00 UTC 1994
