Invitrogen

Calreticulin Recombinant Rabbit Monoclonal Antibody (10J1K8)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-51367

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:50-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10J1K8

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 18-203 of human Calreticulin (NP_004334.1).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094165

Product Specific Information

Immunogen sequence: EPAVYFKEQF LDGDGWTSRW IESKHKSDFG KFVLSSGKFY GDEEKDKGLQ TSQDARFYAL SASFEPFSNK GQTLVVQFTV KHEQNIDCGG GYVKLFPNSL DQTDMHGDSE YNIMFGPDIC GPGTKKVHVI FNYKGKNVLI NKDIRCKDDE FTHLYTLIVR PDNTYEVKID NSQVESGSLE DDWDFL

Target Information

Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Autoantigen RO; CABP3; CALBP; Calcium-binding protein 3; Calregulin; Calreticulin; CRP55; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin)

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Gene Aliases: CALR; Calregulin; cC1qR; CRT; CRTC; HEL-S-99n; RO; SSA

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UniProt ID: (Human) P27797, (Mouse) P14211, (Rat) P18418

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Entrez Gene ID: (Human) 811, (Mouse) 12317, (Rat) 64202

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Function(s)
complement component C1q binding glycoprotein binding DNA binding mRNA binding integrin binding iron ion binding calcium ion binding protein binding zinc ion binding carbohydrate binding ubiquitin protein ligase binding peptide binding hormone binding protein binding involved in protein folding poly(A) RNA binding androgen receptor binding unfolded protein binding chaperone binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter peptide antigen assembly with MHC class I protein complex protein folding protein export from nucleus cell cycle arrest positive regulation of cell proliferation positive regulation of gene expression negative regulation of translation cortical actin cytoskeleton organization negative regulation of intracellular steroid hormone receptor signaling pathway protein localization to nucleus regulation of meiotic nuclear division negative regulation of neuron differentiation positive regulation of DNA replication positive regulation of cell cycle negative regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway positive regulation of phagocytosis protein stabilization chaperone-mediated protein folding cellular senescence positive regulation of substrate adhesion-dependent cell spreading positive regulation of dendritic cell chemotaxis spermatogenesis response to organic substance response to estradiol response to testosterone response to drug cardiac muscle cell differentiation cellular response to lithium ion cellular response to organic substance antigen processing and presentation of peptide antigen via MHC class I regulation of transcription, DNA-templated cellular calcium ion homeostasis receptor-mediated endocytosis protein maturation by protein folding protein folding in endoplasmic reticulum ATF6-mediated unfolded protein response glucocorticoid receptor signaling pathway regulation of apoptotic process sequestering of calcium ion
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