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Alomone Labs, LTD
Cannabinoid Receptor 2 (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
Cannabinoid Receptor 2 (extracellular) Antibody (ACR-003-200UL) in ICC/IF
Expression of CB2 receptor in human LNCaP - Immunocytochemical staining of living human prostate carcinoma cells (LNCaP). A. Extracellular staining of cells with Anti-Human Cannabinoid Receptor 2 (extracellular) Antibody (#ACR-003), (1:50), followed by goat- Anti-rabbit-AlexaFluor-488 secondary Antibody .B. Nuclear staining of LNCaP cells with Hoechst 33342. C. Live intact LNCaP cells.
Product Details
ACR-003-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)NGSKDGLDSNPMKD, corresponding to amino acid residues 11-24 of human CB2 receptor, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cannabinoid Receptor 2; cannabinoid receptor 2 (macrophage); CB-2; CB2R; CNR3; CX5; HCB2; HGNC:2160; OTTHUMP00000044841; RP11-4M23.1; testis-dominant CNR2 isoform CB2
Gene Aliases: CB-2; CB2; CB2A; CB2B; CNR2; CX5
UniProt ID: (Human) P34972
Entrez Gene ID: (Human) 1269
response to amphetamine
inflammatory response
immune response
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
sensory perception of pain
negative regulation of synaptic transmission, GABAergic
response to lipopolysaccharide
negative regulation of mast cell activation
cannabinoid signaling pathway
negative regulation of action potential
negative regulation of inflammatory response
negative regulation of nitric-oxide synthase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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