Proteintech

Carboxypeptidase A1 Polyclonal Antibody

Carboxypeptidase A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Carboxypeptidase A1 Antibody (15836-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta using 15836-1-AP (Carboxypeptidase A1 antibody) at dilution of 1:100 (under 40x lens).

Carboxypeptidase A1 Antibody in Western Blot (WB)

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Product Details

15836-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carboxypeptidase A1 Fusion Protein Ag8586 (71-419 aa encoded by BC005279)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to CPA1.

Immunogen sequence: SIQAVKIFL ESHGISYETM IEDVQSLLDE EQEQMFAFRS RARSTDTFNY ATYHTLEEIY DFLDLLVAEN PHLVSKIQIG NTYEGRPIYV LKFSTGGSKR PAIWIDTGIH SREWVTQASG VWFAKKITQD YGQDAAFTAI LDTLDIFLEI VTNPDGFAFT HSTNRMWRKT RSHTAGSLCI GVDPNRNWDA GFGLSGASSN PCSETYRGKF ANSEVEVKSI VDFVKDHGNI KAFISIHSYS QLLMYPYGYK TEPVPDQDEL DQLSKAAVTA LASLYGTKFN YGSIIKAIYQ ASGSTIDWTY SQGIKYSFTF ELRDTGRYGF LLPASQIIPT AKETWLALLT IMEHTLNHPY (71-419 aa encoded by BC005279)

Target Information

CPA1, also known as CPA, is a 419 amino acid secreted monomeric protein that is highly expressed in pancreatic tissue. Functioning as a pancreatic exopeptidase, CPA1 uses zinc as a cofactor to catalyze the release of C-terminal amino acids from a variety of proteins, thereby playing a key role in protein digestion and degradation. Via its catalytic activity, CPA1 is also thought to be involved in zymogen (proenzyme) inhibition, probably functioning to block enzyme activation pathways. Abnormal levels of CPA1 are associated with pancreatic cancer, suggesting a possible role in either tumor progression or tumor suppression events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in β cells.

The Journal of nutritional biochemistry

Li C,Zhu J,Wei S,Ye X,Yang L,Wang Z,Chen Y

Sat Apr 01 00:00:00 UTC 2023

Focal adhesion kinase-mediated signaling controls the onset of pancreatic cell differentiation.

Development (Cambridge, England)

Rodriguez UA,Dahiya S,Raymond ML,Gao C,Martins-Cargill CP,Piganelli JD,Gittes GK,Hu J,Esni F

Thu Sep 01 00:00:00 UTC 2022

Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Jia X,Sun B,Tu Q,Qi H,Li L,Liu X,Yan L,Dai H,Kong Q,Tang C,Zhao X

Mon Mar 01 00:00:00 UTC 2021

A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal.

Disease models & mechanisms

Tu Q,Yang D,Zhang X,Jia X,An S,Yan L,Dai H,Ma Y,Tang C,Tong W,Hou Z,Lv L,Tan J,Zhao X

Mon Apr 15 00:00:00 UTC 2019

αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation.

Cell reports

Jimenez-Caliani AJ,Pillich R,Yang W,Diaferia GR,Meda P,Crisa L,Cirulli V

Tue Aug 08 00:00:00 UTC 2017

αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation.

Cell reports

Jimenez-Caliani AJ,Pillich R,Yang W,Diaferia GR,Meda P,Crisa L,Cirulli V

Tue Aug 08 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Carboxypeptidase A1; carboxypeptidase A1 (pancreatic); pancreatic carboxypeptidase A

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Gene Aliases: 0910001L12Rik; CPA; CPA1

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UniProt ID: (Human) P15085, (Mouse) Q7TPZ8, (Rat) P00731

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Entrez Gene ID: (Human) 1357, (Mouse) 109697, (Rat) 24269

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Function(s)

metallocarboxypeptidase activity zinc ion binding carboxypeptidase activity peptidase activity metallopeptidase activity exopeptidase activity hydrolase activity metal ion binding

Process(es)

proteolysis proteolysis involved in cellular protein catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Carboxypeptidase A1 Polyclonal Antibody

Carboxypeptidase A1 Antibody (15836-1-AP) in IHC (P)

Product Details

15836-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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